Rv3457c

Tuberculist information
Gene namerpoA
Protein functionProbable DNA-directed RNA polymerase (alpha chain) RpoA (transcriptase alpha chain) (RNA polymerase alpha subunit) (DNA-directed RNA nucleotidyltransferase)
Functional category(tuberculist)information pathways
Gene location(kb)3877.46
Molecular mass(da)37706.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 347
	  		  	1    MLISQRPTLSEDVLTDNRSQFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIRIDGVL   60
			  	61   HEFTTVPGVKEDVTEIILNLKSLVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTVHN  120
			  	121  PGMHIATLNDKGKLEVELVVERGRGYVPAVQNRASGAEIGRIPVDSIYSPVLKVTYKVDA  180
			  	181  TRVEQRTDFDKLILDVETKNSISPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAE  240
			  	241  ADHIASFALPIDDLDLTVRSYNCLKREGVHTVGELVARTESDLLDIRNFGQKSIDEVKIK  300
			  	301  LHQLGLSLKDSPPSFDPSEVAGYDVATGTWSTEGAYDEQDYAETEQL

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 23 to 220  |  Coverage: 56% RNA_pol_L Range: 52 to 152  |  Coverage: 28% RNA_pol_A_bac Range: 237 to 303  |  Coverage: 19% RNA_pol_A_CTD Range: 249 to 309  |  Coverage: 17% 1 Range: 244 to 315  |  Coverage: 20% 2 Range: 5 to 229  |  Coverage: 64% 3 Range: 1 to 232  |  Coverage: 66% 1 Range: 240 to 322  |  Coverage: 23% 2 Range: 52 to 152  |  Coverage: 28% 3
Number of amino acids : 347
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
RNA_pol_LPF0119323-220
RNA_pol_A_bacPF0100052-152
RNA_pol_A_CTDPF03118237-303
Mtb Structural Proteome models
Model Number1
Model nameRv3457c.4
Template1Z3E    BPDBCREDO
Template coverage251_311
Template Identity(%)57.4
Model coverage(%)17.3
Normalized DOPE score-2.346

Model Number2
Model nameRv3457c.3
Template1LB2    BPDBCREDO
Template coverage250_321
Template Identity(%)47.2
Model coverage(%)20.5
Normalized DOPE score-1.346

Model Number3
Model nameRv3457c
Template1YNJ    APDBCREDO
Template coverage7_232
Template Identity(%)50.7
Model coverage(%)64.6
Normalized DOPE score-0.396

Structure Models from Chopin
Model Number1
Profile2.170.120.12, 3.30.1360.10
Click for model details
zscore23.24
Residue begin1
Residue end232
Model Number2
Profilea.60.3.1 - 1.10.150.20
Click for model details
zscore21.73
Residue begin240
Residue end322
Model Number3
Profiled.181.1.1
Click for model details
zscore16.31
Residue begin52
Residue end152
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3457cGene nameConfidence Score
Rv0668rpoC0.999
Rv3676crp0.999
Rv0667rpoB0.999
Rv0668rpoC0.999
Rv0667rpoB0.999
Rv0668rpoC0.999
Rv0667rpoB0.999
Rv0668rpoC0.999
Rv0667rpoB0.999
Rv0668rpoC0.999
Rv0667rpoB0.999
Rv0667rpoB0.999
Rv3676crp0.999
Rv3456crplQ0.998
Rv3458crpsD0.998
Rv3458crpsD0.998
Rv0732secY0.997
Rv0707rpsC0.997
Rv0716rplE0.997
Rv0707rpsC0.997
Rv3459crpsK0.997
Rv0716rplE0.997
Rv3460crpsM0.997
Rv0683rpsG0.996
Rv2783cgpsI0.995
Rv0710rpsQ0.995
Rv2783cgpsI0.995
Rv0705rpsS0.995
Rv2783cgpsI0.995
Rv0701rplC0.995
Rv2783cgpsI0.995
Rv0708rplP0.995
Rv2783cgpsI0.995
Rv0639nusG0.994
Rv0704rplB0.994
Rv0721rpsE0.994
Rv0721rpsE0.994
Rv0703rplW0.994
Rv0639nusG0.994
Rv0704rplB0.994
Rv0719rplF0.993
Rv0700rpsJ0.993
Rv0641rplA0.993
Rv0682rpsL0.993
Rv0652rplL0.993
Rv0720rplR0.992
Rv0702rplD0.992
Rv3443crplM0.992
Rv0684fusA10.991
Rv0723rplO0.991
Rv0684fusA10.991
Rv0714rplN0.991
Rv0684fusA10.991
Rv0715rplX0.991
Rv0684fusA10.991
Rv0684fusA10.991
Rv0718rpsH0.99
Rv0640rplK0.99
Rv0640rplK0.99
Rv0706rplV0.99
Rv2583crelA0.987
Rv2583crelA0.987
Rv2583crelA0.987
Rv2583crelA0.987
Rv0685tuf0.986
Rv0685tuf0.986
Rv3442crpsI0.986
Rv0685tuf0.986
Rv3455ctruA0.985
Rv1699pyrG0.984
Rv1699pyrG0.984
Rv0717rpsN10.983
Rv0722rpmD0.982
Rv2445cndkA0.982
Rv2890crpsB0.981
Rv2056crpsN20.979
Rv2906ctrmD0.979
Rv1617pykA0.979
Rv0651rplJ0.979
Rv1617pykA0.979
Rv0733adk0.978
Rv0734mapA0.975
Rv1297rho0.974
Rv2703sigA0.974
Rv1297rho0.974
Rv2703sigA0.974
Rv1297rho0.974
Rv2703sigA0.974
Rv2703sigA0.974
Rv1308atpA0.973
Rv1308atpA0.973
Rv1308atpA0.973
Rv1023eno0.971
Rv2462ctig0.971
Rv2889ctsf0.971
Rv1080cgreA0.971
Rv2462ctig0.971
Rv1080cgreA0.971
Rv2462ctig0.971
Rv1023eno0.971
Rv2889ctsf0.971
Rv1641infC0.967
Rv1641infC0.967
Rv2904crplS0.967
Rv2861cmapB0.967
Rv0709rpmC0.966
Rv3462cinfA0.961
Rv0350dnaK0.961
Rv2841cnusA0.957
Rv2841cnusA0.957
Rv0056rplI0.957
Rv0056rplI0.957
Rv2710sigB0.955
Rv2710sigB0.955
Rv2710sigB0.955
Rv2710sigB0.955
Rv2883cpyrH0.953
Rv1341Rv13410.948
Rv0120cfusA20.946
Rv0120cfusA20.946
Rv0120cfusA20.946
Rv0053rpsF0.946
Rv0120cfusA20.946
Rv0120cfusA20.946
Rv2785crpsO0.944
Rv2839cinfB0.943
Rv2839cinfB0.943
Rv2839cinfB0.943
Rv2839cinfB0.943
Rv1630rpsA0.943
Rv1643rplT0.942
Rv3100csmpB0.938
Rv3461crpmJ0.936
Rv2441crpmA0.935
Rv1649pheS0.932
Rv1649pheS0.932
Rv0041leuS0.929
Rv0041leuS0.929
Rv0041leuS0.929
Rv3646ctopA0.927
Rv3646ctopA0.927
Rv3646ctopA0.927
Rv2907crimM0.925
Rv2907crimM0.925
Rv2909crpsP0.918
Rv2916cffh0.912
Rv2916cffh0.912
Rv2916cffh0.912
Rv2150cftsZ0.909
Rv2150cftsZ0.909
Rv1021Rv10210.909
Rv3834cserS0.908
Rv3834cserS0.908
Rv0440groEL20.906
Rv2580chisS0.902
Rv2580chisS0.902
Rv2412rpsT0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
ara-CTPPubChem0.9483.156
cytidine triphosphatePubChem0.9483.156
uridine triphosphatePubChem0.9484.141
guanosine triphosphatePubChem0.9523.18
adenosine triphosphatePubChem0.9507.181
magnesiumPubChem0.79524.305
zincPubChem0.78565.409
guanosine tetraphosphatePubChem0.758603.16
sulfatePubChem0.70896.0626
Na(+)PubChem0.70122.9898
cyclic AMPPubChem0.701329.206