Rv2462c

Tuberculist information
Gene nametig
Protein functionProbable trigger factor (TF) protein Tig
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)2763.89
Molecular mass(da)50584
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 466
	  		  	1    VKSTVEQLSPTRVRINVEVPFAELEPDFQRAYKELAKQVRLPGFRPGKAPAKLLEARIGR   60
			  	61   EAMLDQIVNDALPSRYGQAVAESDVQPLGRPNIEVTKKEYGQDLQFTAEVDIRPKISPPD  120
			  	121  LSALTVSVDPIEIGEDDVDAELQSLRTRFGTLTAVDRPVAVGDVVSIDLSATVDGEDIPN  180
			  	181  AAAEGLSHEVGSGRLIAGLDDAVVGLSADESRVFTAKLAAGEHAGQEAQVTVTVRSVKER  240
			  	241  ELPEPDDEFAQLASEFDSIDELRASLSDQVRQAKRAQQAEQIRNATIDALLEQVDVPLPE  300
			  	301  SYVQAQFDSVLHSALSGLNHDEARFNELLVEQGSSRAAFDAEARTASEKDVKRQLLLDAL  360
			  	361  ADELQVQVGQDDLTERLVTTSRQYGIEPQQLFGYLQERNQLPTMFADVRRELAIRAAVEA  420
			  	421  ATVTDSDGNTIDTSEFFGKRVSAGEAEEAEPADEGAARAASDEATT

Known structures in the PDB
No Known structures
1 47 93 139 185 231 277 323 369 415 461 Range: 1 to 146  |  Coverage: 31% Trigger_N Range: 156 to 238  |  Coverage: 17% FKBP_C Range: 258 to 419  |  Coverage: 34% Trigger_C Range: 1 to 440  |  Coverage: 94% 1 Range: 1 to 438  |  Coverage: 93% 1 Range: 1 to 118  |  Coverage: 25% 2 Range: 211 to 383  |  Coverage: 36% 3 Range: 258 to 381  |  Coverage: 26% 4 Range: 121 to 247  |  Coverage: 27% 5
Number of amino acids : 466
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Trigger_NPF056971-146
FKBP_CPF00254156-238
Trigger_CPF05698258-419
Mtb Structural Proteome models
Model Number1
Model nameRv2462c
Template1W26    APDBCREDO
Template coverage1_431
Template Identity(%)23.0
Model coverage(%)94.2
Normalized DOPE score0.611

Structure Models from Chopin
Model Number1
Profilea.223.1.1, d.241.2.1, d.26.1.1 - 3.10.50.40, 3.30.70.1050
Click for model details
zscore50.53
Residue begin1
Residue end438
Model Number2
Profiled.241.2.1 - 3.30.70.1050
Click for model details
zscore33.58
Residue begin1
Residue end118
Model Number3
Profile1.10.3120.10
Click for model details
zscore18.05
Residue begin211
Residue end383
Model Number4
Profilea.223.1.1
Click for model details
zscore11.99
Residue begin258
Residue end381
Model Number5
Profiled.26.1.1 - 3.10.50.40
Click for model details
zscore11.6
Residue begin121
Residue end247
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2462cGene nameConfidence Score
Rv2461cclpP10.992
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv2460cclpP20.98
Rv0440groEL20.974
Rv0350dnaK0.972
Rv3417cgroEL10.972
Rv3457crpoA0.971
Rv3457crpoA0.971
Rv3457crpoA0.971
Rv0639nusG0.97
Rv0639nusG0.97
Rv2916cffh0.969
Rv2916cffh0.969
Rv2916cffh0.969
Rv2448cvalS0.966
Rv2448cvalS0.966
Rv2448cvalS0.966
Rv0652rplL0.963
Rv2889ctsf0.961
Rv2889ctsf0.961
Rv1630rpsA0.96
Rv0685tuf0.959
Rv0685tuf0.959
Rv2457cclpX0.959
Rv0685tuf0.959
Rv2457cclpX0.959
Rv2457cclpX0.959
Rv2890crpsB0.956
Rv0707rpsC0.955
Rv0707rpsC0.955
Rv0732secY0.954
Rv0701rplC0.949
Rv0702rplD0.949
Rv0703rplW0.949
Rv1023eno0.943
Rv2921cftsY0.943
Rv2921cftsY0.943
Rv1023eno0.943
Rv0683rpsG0.942
Rv0651rplJ0.941
Rv0668rpoC0.94
Rv0668rpoC0.94
Rv0668rpoC0.94
Rv0668rpoC0.94
Rv0668rpoC0.94
Rv0641rplA0.937
Rv2783cgpsI0.936
Rv2783cgpsI0.936
Rv2783cgpsI0.936
Rv2783cgpsI0.936
Rv2783cgpsI0.936
Rv2839cinfB0.935
Rv2839cinfB0.935
Rv2839cinfB0.935
Rv2839cinfB0.935
Rv3442crpsI0.933
Rv1015crplY0.931
Rv0056rplI0.931
Rv1015crplY0.931
Rv0056rplI0.931
Rv0716rplE0.927
Rv0716rplE0.927
Rv0640rplK0.924
Rv2534cefp0.924
Rv2534cefp0.924
Rv0053rpsF0.924
Rv2534cefp0.924
Rv0640rplK0.924
Rv1848ureA0.92
Rv0704rplB0.919
Rv0704rplB0.919
Rv0682rpsL0.918
Rv1437pgk0.918
Rv3646ctopA0.915
Rv3646ctopA0.915
Rv2785crpsO0.915
Rv3646ctopA0.915
Rv3458crpsD0.913
Rv3458crpsD0.913
Rv2441crpmA0.913
Rv1638uvrA0.911
Rv0684fusA10.91
Rv0684fusA10.91
Rv0684fusA10.91
Rv0684fusA10.91
Rv0684fusA10.91
Rv1641infC0.906
Rv1641infC0.906
Rv1080cgreA0.906
Rv1080cgreA0.906
Rv0700rpsJ0.906
Rv2445cndkA0.905
Rv3443crplM0.904
Rv2150cftsZ0.903
Rv2150cftsZ0.903
Rv0351grpE0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
Coomassie bluePubChem0.816695.584
tacrolimusPubChem0.775804.018