Rv1437

Tuberculist information
Gene namepgk
Protein functionProbable phosphoglycerate kinase Pgk
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1614.33
Molecular mass(da)42512.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 412
	  		  	1    MSVANLKDLLAEGVSGRGVLVRSDLNVPLDEDGTITDAGRIIASAPTLKALLDADAKVVV   60
			  	61   AAHLGRPKDGPDPTLSLAPVAVALGEQLGRHVQLAGDVVGADALARAEGLTGGDILLLEN  120
			  	121  IRFDKRETSKNDDDRRALAKQLVELVGTGGVFVSDGFGVVHRKQASVYDIATLLPHYAGT  180
			  	181  LVADEMRVLEQLTSSTQRPYAVVLGGSKVSDKLGVIESLATKADSIVIGGGMCFTFLAAQ  240
			  	241  GFSVGTSLLEDDMIEVCRGLLETYHDVLRLPVDLVVTEKFAADSPPQTVDVGAVPNGLMG  300
			  	301  LDIGPGSIKRFSTLLSNAGTIFWNGPMGVFEFPAYAAGTRGVAEAIVAATGKGAFSVVGG  360
			  	361  GDSAAAVRAMNIPEGAFSHISTGGGASLEYLEGKTLPGIEVLSREQPTGGVL

Known structures in the PDB
No Known structures
1 42 83 124 165 206 247 288 329 370 411 Range: 5 to 394  |  Coverage: 94% PGK Range: 8 to 406  |  Coverage: 96% 1 Range: 1 to 412  |  Coverage: 99% 1
Number of amino acids : 412
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PGKPF001625-394
Mtb Structural Proteome models
Model Number1
Model nameRv1437
Template1VPE    APDBCREDO
Template coverage5_398
Template Identity(%)48.5
Model coverage(%)96.6
Normalized DOPE score-0.918

Structure Models from Chopin
Model Number1
Profilec.86.1.1
Click for model details
zscore65.53
Residue begin1
Residue end412
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1437Gene nameConfidence Score
Rv1436gap0.999
Rv1438tpi0.999
Rv1023eno0.999
Rv1023eno0.999
Rv1436gap0.999
Rv1617pykA0.998
Rv0363cfba0.998
Rv1617pykA0.998
Rv0489gpm10.996
Rv1449ctkt0.99
Rv1449ctkt0.99
Rv1449ctkt0.99
Rv0946cpgi0.985
Rv0350dnaK0.984
Rv3010cpfkA0.972
Rv1240mdh0.967
Rv1240mdh0.967
Rv0684fusA10.966
Rv0684fusA10.966
Rv0684fusA10.966
Rv0684fusA10.966
Rv0684fusA10.966
Rv2783cgpsI0.962
Rv2783cgpsI0.962
Rv2783cgpsI0.962
Rv2783cgpsI0.962
Rv2783cgpsI0.962
Rv3846sodA0.956
Rv3846sodA0.956
Rv2419cRv2419c0.952
Rv1408rpe0.943
Rv0409ackA0.941
Rv1448ctal0.938
Rv2992cgltS0.938
Rv0408pta0.935
Rv0408pta0.935
Rv0408pta0.935
Rv0440groEL20.933
Rv0733adk0.927
Rv3214gpm20.925
Rv0462lpdC0.924
Rv0462lpdC0.924
Rv0462lpdC0.924
Rv0070cglyA20.923
Rv0716rplE0.922
Rv2534cefp0.922
Rv2534cefp0.922
Rv2534cefp0.922
Rv0716rplE0.922
Rv3417cgroEL10.921
Rv1093glyA10.921
Rv2299chtpG0.92
Rv2299chtpG0.92
Rv1633uvrB0.919
Rv1633uvrB0.919
Rv1633uvrB0.919
Rv1633uvrB0.919
Rv2462ctig0.918
Rv2462ctig0.918
Rv2462ctig0.918
Rv2839cinfB0.916
Rv2839cinfB0.916
Rv2839cinfB0.916
Rv2839cinfB0.916
Rv2428ahpC0.913
Rv3838cpheA0.911
Rv3838cpheA0.911
Rv3709cask0.91
Rv3709cask0.91
Rv3709cask0.91
Rv3708casd0.91
Rv3708casd0.91
Rv2580chisS0.908
Rv2580chisS0.908
Rv2150cftsZ0.906
Rv2150cftsZ0.906
Rv3837cRv3837c0.903
Rv2445cndkA0.903
Rv3396cguaA0.902
Rv3396cguaA0.902
Rv3396cguaA0.902
Rv1392metK0.901
Rv1392metK0.901
Rv1392metK0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
3-phosphoglyceratePubChem0.998186.057
phosphatePubChem0.9996.9872
magnesiumPubChem0.98824.305
1,3-diphosphoglyceratePubChem0.986266.037
adenosine triphosphatePubChem0.986507.181
phosphoglyceratePubChem0.974186.057
1,3-bisphosphoglyceratePubChem0.961266.037
D-glyceraldehyde-3-phosphatePubChem0.956170.058
adenosine diphosphatePubChem0.952427.201
glyceraldehyde-3-phosphatePubChem0.946170.058
NAD+PubChem0.936663.425
glycerolPubChem0.92592.0938
reduced nicotinamide adenine dinucleotidePubChem0.92665.441
H(+)PubChem0.92.01588
(2S)-3-hydroxy-2-phosphato-propionatePubChem0.9183.033
2-phospho-D-glyceratePubChem0.9186.057
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
1,3-bisphospho-d-glyceratePubChem0.9266.037
2,3-diphosphoglyceratePubChem0.882266.037
sulfatePubChem0.83296.0626
hydron sulfatePubChem0.773196.157
magnesium fluoridePubChem0.7762.3018
Na(+)PubChem0.76222.9898
adenosine monophosphatePubChem0.761347.221
hydron diphosphatePubChem0.757391.981
chloridePubChem0.7435.453
ATP analogPubChem0.737505.208
aluminum fluoridePubChem0.7383.9767
calciumPubChem0.72940.078
acetaldehydePubChem0.71144.0526
SeMetPubChem0.707196.106
selenomethioninePubChem0.707196.106
bvPubChem0.702582.646