Rv0489

Tuberculist information
Gene namegpm1
Protein functionProbable phosphoglycerate mutase 1 Gpm1 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)578.426
Molecular mass(da)27215.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 249
	  		  	1    MANTGSLVLLRHGESDWNALNLFTGWVDVGLTDKGQAEAVRSGELIAEHDLLPDVLYTSL   60
			  	61   LRRAITTAHLALDSADRLWIPVRRSWRLNERHYGALQGLDKAETKARYGEEQFMAWRRSY  120
			  	121  DTPPPPIERGSQFSQDADPRYADIGGGPLTECLADVVARFLPYFTDVIVGDLRVGKTVLI  180
			  	181  VAHGNSLRALVKHLDQMSDDEIVGLNIPTGIPLRYDLDSAMRPLVRGGTYLDPEAAAAGA  240
			  	241  AAVAGQGRG

Known structures in the PDB
PDB ID1RII
Total residue count1060
Number of chains4
MethodX-RAY
Resolution1.7
1 25 49 73 97 121 145 169 193 217 241 Range: 6 to 190  |  Coverage: 73% His_Phos_1 Range: 2 to 244  |  Coverage: 97% 1 Range: 2 to 244  |  Coverage: 97% 2 Range: 1 to 249  |  Coverage: 99% 1
Number of amino acids : 249
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
His_Phos_1PF003006-190
Mtb Structural Proteome models
Model Number1
Model nameRv0489_1rii_A
Template1RII    APDBCREDO
Template coverage2_244
Template Identity(%)100.0
Model coverage(%)96.8
Normalized DOPE score-1.401

Model Number2
Model nameRv0489
Template1RII    APDBCREDO
Template coverage2_244
Template Identity(%)100.0
Model coverage(%)96.8
Normalized DOPE score-1.201

Structure Models from Chopin
Model Number1
Profilec.60.1.1 - 3.40.50.1240
Click for model details
zscore42.96
Residue begin1
Residue end249
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0489Gene nameConfidence Score
Rv1023eno0.998
Rv1023eno0.998
Rv1437pgk0.996
Rv0363cfba0.994
Rv0946cpgi0.987
Rv1438tpi0.985
Rv1617pykA0.969
Rv1617pykA0.969
Rv1436gap0.966
Rv1449ctkt0.966
Rv1449ctkt0.966
Rv1449ctkt0.966
Rv1436gap0.966
Rv2996cserA10.939
Rv2996cserA10.939
Rv2996cserA10.939
Rv0728cserA20.932
Rv0728cserA20.932
Rv2205cRv2205c0.914
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
3-phosphoglyceratePubChem0.99186.057
glycerolPubChem0.97692.0938
phosphoglyceratePubChem0.965186.057
phosphoenolpyruvatePubChem0.943168.042
1,3-bisphosphoglyceratePubChem0.932266.037
adenosine triphosphatePubChem0.925507.181
glyceratePubChem0.907106.077
2-phospho-D-glyceratePubChem0.906186.057
1,3-diphosphoglyceratePubChem0.906266.037
NADPPubChem0.902744.413
adenosine diphosphatePubChem0.9427.201
deuteriumPubChem0.92.01588
1,3-bisphospho-d-glyceratePubChem0.9266.037
NADP(H)PubChem0.9745.421
protiumPubChem0.92.01576
(2S)-3-hydroxy-2-phosphato-propionatePubChem0.9183.033
glyceraldehyde-3-phosphatePubChem0.9170.058
hydroxyl radicalsPubChem0.917.0073
D-glyceraldehyde-3-phosphatePubChem0.9170.058
H(+)PubChem0.92.01588
2,3-diphosphoglyceratePubChem0.873266.037
2-amino-3-(1-phosphonoimidazol-4-yl)propanoic acidPubChem0.787235.134
2,3-diphospho-D-glyceric acidPubChem0.767266.037
hydron sulfatePubChem0.767196.157
sulfatePubChem0.76796.0626
chloridePubChem0.72435.453
thiocyanatePubChem0.70659.0903
TetrametavanadatePubChem0.701417.806