SInCRe - Rv0363c

Tuberculist information

Gene name	fba
Protein function	Probable fructose-bisphosphate aldolase Fba
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	441.265
Molecular mass(da)	36544.5
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 344

	  		  	1    MPIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFG   60
			  	61   SGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKLDSYVRPLLAISAQRVSKG  120
			  	121  GNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEIEIGVVGGEEDGVANEINEKL  180
			  	181  YTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPGNVKLRPDILAQGQQVAAAKLGL  240
			  	241  PADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVDTDTQYAFTRPIAGHMFTNYDGVLK  300
			  	301  VDGEVGVKKVYDPRSYLKKAEASMSQRVVQACNDLHCAGKSLTH

Known structures in the PDB

	PDB ID	3EKL
	Total residue count	349
	Number of chains	1
	Method	X-RAY
	Resolution	1.51

	PDB ID	3EKZ
	Total residue count	349
	Number of chains	1
	Method	X-RAY
	Resolution	2.07

	PDB ID	3ELF
	Total residue count	349
	Number of chains	1
	Method	X-RAY
	Resolution	1.31

	PDB ID	4A21
	Total residue count	1376
	Number of chains	4
	Method	X-RAY
	Resolution	2.35

	PDB ID	4A22
	Total residue count	1376
	Number of chains	4
	Method	X-RAY
	Resolution	1.9

	PDB ID	4DEF
	Total residue count	349
	Number of chains	1
	Method	X-RAY
	Resolution	1.64

	PDB ID	4DEL
	Total residue count	349
	Number of chains	1
	Method	X-RAY
	Resolution	1.58

	PDB ID	4LV4
	Total residue count	349
	Number of chains	1
	Method	X-RAY
	Resolution	2.08

Number of amino acids : 344

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
F_bP_aldolase	PF01116	5-341

Mtb Structural Proteome models

Model Number	1
Model name	Rv0363c_3elf_A
Template	3ELF APDB CREDO
Template coverage	2_346
Template Identity(%)	100.0
Model coverage(%)	100.0
Normalized DOPE score	-1.727

Model Number	2
Model name	Rv0363c
Template	1DOS APDB CREDO
Template coverage	11_354
Template Identity(%)	40.6
Model coverage(%)	97.1
Normalized DOPE score	-0.651

Structure Models from Chopin

Model Number	1
Profile	c.1.10.2 - 3.20.20.70 Click for model details
zscore	44.12
Residue begin	1
Residue end	342

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv0363c	Gene name	Confidence Score
Rv1436	gap	0.999
Rv1436	gap	0.999
Rv1438	tpi	0.999
Rv1617	pykA	0.998
Rv1437	pgk	0.998
Rv1617	pykA	0.998
Rv0489	gpm1	0.994
Rv3010c	pfkA	0.993
Rv0946c	pgi	0.993
Rv1449c	tkt	0.992
Rv1449c	tkt	0.992
Rv1449c	tkt	0.992
Rv1023	eno	0.99
Rv1023	eno	0.99
Rv2496c	bkdB	0.984
Rv2496c	bkdB	0.984
Rv1099c	glpX	0.976
Rv2029c	pfkB	0.968
Rv0478	deoC	0.939
Rv1448c	tal	0.939
Rv0409	ackA	0.903

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
dihydroxyacetone phosphatePubChem	0.999	170.058
fructose 1,6-bisphosphatePubChem	0.994	340.116
D-glyceraldehyde-3-phosphatePubChem	0.992	170.058
zincPubChem	0.988	65.409
Na(+)PubChem	0.977	22.9898
glyceraldehyde-3-phosphatePubChem	0.973	170.058
phosphatePubChem	0.938	96.9872
pyrophosphatePubChem	0.937	177.975
D-fructose 1,6-bisphosphatePubChem	0.932	550.183
fructose bisphosphatePubChem	0.929	340.116
H(+)PubChem	0.902	2.01588
deuteriumPubChem	0.902	2.01588
NAD+PubChem	0.9	663.425
1,3-bisphospho-d-glyceratePubChem	0.9	266.037
hydroxyl radicalsPubChem	0.9	17.0073
protiumPubChem	0.9	2.01576
D-fructose 6-phosphatePubChem	0.9	260.136
1,3-bisphosphoglyceratePubChem	0.9	266.037
adenosine diphosphatePubChem	0.9	427.201
glycerol-3-phosphatePubChem	0.9	172.074
1,3-diphosphoglyceratePubChem	0.9	266.037
reduced nicotinamide adenine dinucleotidePubChem	0.9	665.441
D-fructose-6-phosphatePubChem	0.9	260.136
1,6-di-O-phosphono-D-sorbosePubChem	0.9	340.116
adenosine triphosphatePubChem	0.9	507.181
dihydronicotinamide formycin dinucleotidePubChem	0.9	665.441
phosphoglycolohydroxamatePubChem	0.889	171.046
chloridePubChem	0.742	35.453
fructosePubChem	0.726	180.156