Rv1449c

Tuberculist information
Gene nametkt
Protein functionTransketolase Tkt (TK)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1628.1
Molecular mass(da)75556.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 700
	  		  	1    VTTLEEISALTRPRHPDYWTEIDSAAVDTIRVLAADAVQKVGNGHPGTAMSLAPLAYTLF   60
			  	61   QRTMRHDPSDTHWLGRDRFVLSAGHSSLTLYIQLYLGGFGLELSDIESLRTWGSKTPGHP  120
			  	121  EFRHTPGVEITTGPLGQGLASAVGMAMASRYERGLFDPDAEPGASPFDHYIYVIASDGDI  180
			  	181  EEGVTSEASSLAAVQQLGNLIVFYDRNQISIEDDTNIALCEDTAARYRAYGWHVQEVEGG  240
			  	241  ENVVGIEEAIANAQAVTDRPSFIALRTVIGYPAPNLMDTGKAHGAALGDDEVAAVKKIVG  300
			  	301  FDPDKTFQVREDVLTHTRGLVARGKQAHERWQLEFDAWARREPERKALLDRLLAQKLPDG  360
			  	361  WDADLPHWEPGSKALATRAASGAVLSALGPKLPELWGGSADLAGSNNTTIKGADSFGPPS  420
			  	421  ISTKEYTAHWYGRTLHFGVREHAMGAILSGIVLHGPTRAYGGTFLQFSDYMRPAVRLAAL  480
			  	481  MDIDTIYVWTHDSIGLGEDGPTHQPIEHLSALRAIPRLSVVRPADANETAYAWRTILARR  540
			  	541  NGSGPVGLILTRQGVPVLDGTDAEGVARGGYVLSDAGGLQPGEEPDVILIATGSEVQLAV  600
			  	601  AAQTLLADNDILARVVSMPCLEWFEAQPYEYRDAVLPPTVSARVAVEAGVAQCWHQLVGD  660
			  	661  TGEIVSIEHYGESADHKTLFREYGFTAEAVAAAAERALDN

Known structures in the PDB
PDB ID3RIM
Total residue count2800
Number of chains4
MethodX-RAY
Resolution2.49
1 71 141 211 281 351 421 491 561 631 701 Range: 22 to 358  |  Coverage: 48% Transketolase_N Range: 373 to 557  |  Coverage: 26% Transket_pyr Range: 577 to 690  |  Coverage: 16% Transketolase_C Range: 18 to 699  |  Coverage: 97% 1 Range: 1 to 700  |  Coverage: 99% 1 Range: 22 to 358  |  Coverage: 48% 2 Range: 373 to 557  |  Coverage: 26% 3 Range: 577 to 690  |  Coverage: 16% 4
Number of amino acids : 700
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Transketolase_NPF0045622-358
Transket_pyrPF02779373-557
Transketolase_CPF02780577-690
Mtb Structural Proteome models
Model Number1
Model nameRv1449c
Template1GPU    APDBCREDO
Template coverage3_665
Template Identity(%)45.6
Model coverage(%)97.3
Normalized DOPE score-0.994

Structure Models from Chopin
Model Number1
Profilec.36.1.10, c.36.1.6, c.48.1.1 - 3.40.50.920, 3.40.50.970
Click for model details
zscore102.92
Residue begin1
Residue end700
Model Number2
Profilec.36.1.10
Click for model details
zscore56.66
Residue begin22
Residue end358
Model Number3
Profilec.36.1.6
Click for model details
zscore32.43
Residue begin373
Residue end557
Model Number4
Profilec.48.1.1
Click for model details
zscore28.68
Residue begin577
Residue end690
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1449cGene nameConfidence Score
Rv1448ctal0.999
Rv1436gap0.998
Rv1436gap0.998
Rv1408rpe0.998
Rv0946cpgi0.997
Rv1617pykA0.996
Rv1617pykA0.996
Rv2465crpiB0.994
Rv0363cfba0.992
Rv1099cglpX0.991
Rv1447czwf20.991
Rv1447czwf20.991
Rv1437pgk0.99
Rv3010cpfkA0.987
Rv1023eno0.986
Rv1023eno0.986
Rv2436rbsK0.984
Rv1017cprsA0.984
Rv1017cprsA0.984
Rv0478deoC0.98
Rv0843Rv08430.978
Rv1844cgnd10.978
Rv1844cgnd10.978
Rv1445cdevB0.976
Rv1438tpi0.975
Rv0489gpm10.966
Rv3068cpgmA0.963
Rv3068cpgmA0.963
Rv3068cpgmA0.963
Rv2496cbkdB0.963
Rv2496cbkdB0.963
Rv3068cpgmA0.963
Rv0357cpurA0.944
Rv3257cpmmA0.941
Rv3257cpmmA0.941
Rv3257cpmmA0.941
Rv3257cpmmA0.941
Rv1122gnd20.937
Rv1122gnd20.937
Rv0650Rv06500.937
Rv2241aceE0.936
Rv2029cpfkB0.919
Rv1121zwf10.918
Rv1121zwf10.918
Rv2540caroF0.909
Rv2678chemE0.906
Rv2534cefp0.903
Rv2534cefp0.903
Rv2497cbkdA0.903
Rv2534cefp0.903
Rv0733adk0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
erythrose 4-phosphatePubChem0.988200.084
D-ribose 5-phosphatePubChem0.987230.11
ribulose 5-phosphatePubChem0.976230.11
D-glyceraldehyde-3-phosphatePubChem0.974170.058
sedoheptulose-7-phosphatePubChem0.973290.162
sedoheptulose 7-phosphatePubChem0.967290.162
thiamine pyrophosphatePubChem0.958425.314
D-xylulose 5-phosphatePubChem0.948230.11
ribulose-5-phosphatePubChem0.944230.11
glyceraldehyde-3-phosphatePubChem0.929170.058
heptulose 7-phosphatePubChem0.904290.162
D-fructose 6-phosphatePubChem0.903260.136
D-fructose-6-phosphatePubChem0.902260.136
D-erythrose 4-phosphatePubChem0.9200.084
ribose 1-phosphatePubChem0.9230.11
phosphatePubChem0.88796.9872
magnesiumPubChem0.86824.305
calciumPubChem0.82540.078
dihydroxyacetonePubChem0.82190.0779
glycerolPubChem0.80592.0938
acetatePubChem0.80159.044
SeMetPubChem0.793196.106
selenomethioninePubChem0.793196.106
ribose 5-phosphatePubChem0.765230.11
xylulose 5-phosphatePubChem0.761228.094
hydride acetatePubChem0.75661.0599
ethylene glycol; hydronPubChem0.75263.0758
polyethylene glycolPubChem0.75262.0678
polyribosylribitolphosphatePubChem0.747232.126
Zinc04228241PubChem0.742230.11
ribitol-5-phosphatePubChem0.742232.126