Rv1017c

Tuberculist information
Gene nameprsA
Protein functionProbable ribose-phosphate pyrophosphokinase PrsA (phosphoribosyl pyrophosphate synthetase) (PRPP synthetase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1135.5
Molecular mass(da)35459.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 326
	  		  	1    LSHDWTDNRKNLMLFAGRAHPELAEQVAKELDVHVTSQDAREFANGEIFVRFHESVRGCD   60
			  	61   AFVLQSCPAPVNRWLMEQLIMIDALKRGSAKRITAVMPFYPYARQDKKHRGREPISARLI  120
			  	121  ADLLKTAGADRIVTVDLHTDQIQGFFDGPVDHMRGQNLLTGYIRDNYPDGNMVVVSPDSG  180
			  	181  RVRIAEKWADALGGVPLAFIHKTRDPRVPNQVVSNRVVGDVAGRTCVLIDDMIDTGGTIA  240
			  	241  GAVALLHNDGAGDVIIAATHGVLSDPAAQRLASCGAREVIVTNTLPIGEDKRFPQLTVLS  300
			  	301  IAPLLASTIRAVFENGSVTGLFDGDA

Known structures in the PDB
No Known structures
1 33 65 97 129 161 193 225 257 289 321 Range: 12 to 128  |  Coverage: 35% Pribosyltran_N Range: 151 to 260  |  Coverage: 33% Pribosyltran Range: 11 to 322  |  Coverage: 95% 1 Range: 7 to 177  |  Coverage: 52% 1 Range: 164 to 260  |  Coverage: 29% 2
Number of amino acids : 326
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Pribosyltran_NPF1379312-128
PribosyltranPF00156151-260
Mtb Structural Proteome models
Model Number1
Model nameRv1017c
Template1DKU    APDBCREDO
Template coverage8_315
Template Identity(%)46.4
Model coverage(%)95.4
Normalized DOPE score-1.184

Structure Models from Chopin
Model Number1
Profilec.61.1.2
Click for model details
zscore35.09
Residue begin7
Residue end177
Model Number2
Profilec.61.1.2
Click for model details
zscore10.27
Residue begin164
Residue end260
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1017cGene nameConfidence Score
Rv0808purF0.988
Rv0808purF0.988
Rv1018cglmU0.986
Rv1018cglmU0.986
Rv1449ctkt0.984
Rv1449ctkt0.984
Rv1449ctkt0.984
Rv0382cpyrE0.983
Rv1015crplY0.978
Rv1015crplY0.978
Rv2436rbsK0.977
Rv1014cpth0.975
Rv2465crpiB0.975
Rv1112Rv11120.974
Rv1112Rv11120.974
Rv1643rplT0.964
Rv2121chisG0.96
Rv2121chisG0.96
Rv1292argS0.955
Rv1292argS0.955
Rv1292argS0.955
Rv3396cguaA0.95
Rv1011ispE0.95
Rv1011ispE0.95
Rv3309cupp0.95
Rv3396cguaA0.95
Rv3396cguaA0.95
Rv0701rplC0.949
Rv2584capt0.949
Rv3443crplM0.945
Rv1380pyrB0.942
Rv1380pyrB0.942
Rv0053rpsF0.938
Rv2139pyrD0.937
Rv1700Rv17000.937
Rv1020mfd0.929
Rv1020mfd0.929
Rv1020mfd0.929
Rv1020mfd0.929
Rv3068cpgmA0.926
Rv3068cpgmA0.926
Rv3068cpgmA0.926
Rv3068cpgmA0.926
Rv1408rpe0.921
Rv0357cpurA0.921
Rv0640rplK0.92
Rv0640rplK0.92
Rv1389gmk0.92
Rv1699pyrG0.919
Rv1699pyrG0.919
Rv0651rplJ0.91
Rv0056rplI0.908
Rv0056rplI0.908
Rv1023eno0.906
Rv1023eno0.906
Rv3257cpmmA0.904
Rv3257cpmmA0.904
Rv3257cpmmA0.904
Rv3257cpmmA0.904
Rv2889ctsf0.902
Rv2889ctsf0.902
Rv2192ctrpD0.902
Rv0055rpsR10.902
Rv3455ctruA0.902
Rv2192ctrpD0.902
Rv0682rpsL0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
phosphoribosylpyrophosphatePubChem0.991390.07
ribose 5-phosphatePubChem0.99230.11
adenosine monophosphatePubChem0.987347.221
phosphatePubChem0.98596.9872
D-ribose 5-phosphatePubChem0.956230.11
pyrophosphatePubChem0.932177.975
magnesiumPubChem0.92824.305
adenosine triphosphatePubChem0.912507.181
orotic acidPubChem0.904156.096
H(+)PubChem0.92.01588
phosphoribosyl-ATPPubChem0.9719.276
glutamatePubChem0.9147.129
protiumPubChem0.92.01576
deoxyadenosine triphosphatePubChem0.9491.182
5-phosphoribosyl-ATPPubChem0.9714.236
deuteriumPubChem0.92.01588
glutaminPubChem0.9146.145
hydroxyl radicalsPubChem0.917.0073
orotidine 5-phosphatePubChem0.9368.191
orotidine 5'-monophosphatePubChem0.9368.191
5-phosphoribosylaminePubChem0.9229.125
dampPubChem0.9331.222
polyglutaminePubChem0.9146.145
phosphoribosylaminePubChem0.9229.125
polyribosylribitolphosphatePubChem0.823232.126
cadmiumPubChem0.747232.515
sulfatePubChem0.73296.0626
hydron sulfatePubChem0.729196.157
ribulose-5-phosphatePubChem0.71230.11