Rv3068c

Tuberculist information
Gene namepgmA
Protein functionProbable phosphoglucomutase PgmA (glucose phosphomutase) (PGM)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3431.98
Molecular mass(da)58265.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 547
	  		  	1    MVANPRAGQPAQPEDLVDLPHLVTAYYSIEPDPDDLAQQVAFGTSGHRGSALTGTFNELH   60
			  	61   ILAITQAIVEYRAAQGTTGPLFIGRDTHGLSEPAWVSALEVLAANQVVAVVDSRDRYTPT  120
			  	121  PAISHAILTYNRGRTEALADGIVVTPSHNPPSDGGIKYNPPNGGPADTAATTAIAKRANE  180
			  	181  ILLARSMVKRLPLARALRTAQRHDYLGHYVDDLPNVVDIAAIREAGVRIGADPLGGASVD  240
			  	241  YWGEIAHRHGLDLTVVNPLVDATWRFMTLDTDGKIRMDCSSPDAMAGLIRTMFGNRERYQ  300
			  	301  IATGNDADADRHGIVTPDEGLLNPNHYLAVAIEYLYTHRPSWPAGIAVGKTVVSSSIIDR  360
			  	361  VVAGIGRQLVEVPVGFKWFVDGLIGATLGFGGEESAGASFLRRDGSVWTTDKDGIIMALL  420
			  	421  AAEILAVTGATPSQRYHALAGEYGGPCYARIDAPADREQKARLARLSADQVSATELAGEP  480
			  	481  ITAKLTTAPGNGAALGGLKVTTANAWFAARPSGTEDVYKIYAESFRGPQHLVEVQQTARE  540
			  	541  VVDRVIG

Known structures in the PDB
No Known structures
1 55 109 163 217 271 325 379 433 487 541 Range: 39 to 185  |  Coverage: 26% PGM_PMM_I Range: 207 to 320  |  Coverage: 20% PGM_PMM_II Range: 323 to 443  |  Coverage: 21% PGM_PMM_III Range: 458 to 543  |  Coverage: 15% PGM_PMM_IV Range: 6 to 546  |  Coverage: 98% 1 Range: 2 to 547  |  Coverage: 99% 1 Range: 458 to 543  |  Coverage: 15% 2 Range: 39 to 185  |  Coverage: 26% 3
Number of amino acids : 547
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PGM_PMM_IPF0287839-185
PGM_PMM_IIPF02879207-320
PGM_PMM_IIIPF02880323-443
PGM_PMM_IVPF00408458-543
Mtb Structural Proteome models
Model Number1
Model nameRv3068c
Template2FUV    APDBCREDO
Template coverage6_543
Template Identity(%)59.1
Model coverage(%)98.7
Normalized DOPE score-1.065

Structure Models from Chopin
Model Number1
Profile3.30.310.50, 3.40.120.10
Click for model details
zscore66.17
Residue begin2
Residue end547
Model Number2
Profile3.30.310.50
Click for model details
zscore19.85
Residue begin458
Residue end543
Model Number3
Profile3.40.120.10
Click for model details
zscore18.84
Residue begin39
Residue end185
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3068cGene nameConfidence Score
Rv0946cpgi0.997
Rv1328glgP0.983
Rv1328glgP0.983
Rv1213glgC0.982
Rv1213glgC0.982
Rv0650Rv06500.966
Rv1449ctkt0.963
Rv1449ctkt0.963
Rv1449ctkt0.963
Rv0046cino10.962
Rv0046cino10.962
Rv2702ppgK0.958
Rv0733adk0.951
Rv0993galU0.945
Rv2436rbsK0.93
Rv1017cprsA0.926
Rv1017cprsA0.926
Rv1448ctal0.923
Rv0619galTb0.91
Rv0618galTa0.906
Rv2465crpiB0.902
Rv3257cpmmA0.901
Rv1326cglgB0.901
Rv3257cpmmA0.901
Rv3257cpmmA0.901
Rv1326cglgB0.901
Rv3257cpmmA0.901
Rv1326cglgB0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glucose-1-phosphatePubChem0.943260.136
UDP-glucosePubChem0.933566.302
glucose-6-phosphatePubChem0.915260.136
phosphatePubChem0.91196.9872
D-ribose 5-phosphatePubChem0.9230.11
alpha-D-glucose 6-phosphatePubChem0.9260.136
beta-glucanPubChem0.9504.437
maltotriosePubChem0.9504.437
protiumPubChem0.92.01576
H(+)PubChem0.92.01588
UDP-GlcPubChem0.9566.302
mannanPubChem0.9666.578
glucose-6-PPubChem0.9260.136
maltotetraosePubChem0.9666.578
pyrophosphatePubChem0.9177.975
uridine triphosphatePubChem0.9484.141
deuteriumPubChem0.92.01588
magnesiumPubChem0.70424.305
selenomethioninePubChem0.703196.106
SeMetPubChem0.703196.106