Rv1448c

Tuberculist information
Gene nametal
Protein functionProbable transaldolase Tal
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1626.96
Molecular mass(da)40720.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 373
	  		  	1    MTAQNPNLAALSAAGVSVWLDDLSRDRLRSGNLQELIDTKSVVGVTTNPSIFQKALSEGH   60
			  	61   TYDAQIAELAARGADVDATIRTVTTDDVRSACDVLVPQWEDSDGVDGRVSIEVDPRLAHE  120
			  	121  TEKTIQQAIELWKIVDRPNLFIKIPATKAGLPAISAVLAEGISVNVTLIFSVQRYREVMD  180
			  	181  AYLTGMEKARQAGHSLSKIHSVASFFVSRVDTEIDKRLDRIGSRQALELRGQAGVANARL  240
			  	241  AYATYREVFEDSDRYRSLKVDGARVQRPLWASTGVKNPDYSDTLYVTELVAPHTVNTMPE  300
			  	301  KTIDAVADHGVIQGDTVTGTASDAQAVFDQLGAIGIDLTDVFAVLEEEGVRKFEASWNEL  360
			  	361  LQETRAHLDTAAQ

Known structures in the PDB
No Known structures
1 38 75 112 149 186 223 260 297 334 371 Range: 18 to 364  |  Coverage: 92% Transaldolase Range: 6 to 364  |  Coverage: 95% 1 Range: 1 to 364  |  Coverage: 97% 1
Number of amino acids : 373
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
TransaldolasePF0092318-364
Mtb Structural Proteome models
Model Number1
Model nameRv1448c
Template1ONR    APDBCREDO
Template coverage3_313
Template Identity(%)23.2
Model coverage(%)96.0
Normalized DOPE score-0.35

Structure Models from Chopin
Model Number1
Profilea.294.1.1
Click for model details
zscore4.04
Residue begin1
Residue end364
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1448cGene nameConfidence Score
Rv1449ctkt0.999
Rv1449ctkt0.999
Rv1449ctkt0.999
Rv0946cpgi0.997
Rv1617pykA0.989
Rv1617pykA0.989
Rv1447czwf20.988
Rv1447czwf20.988
Rv1023eno0.975
Rv1023eno0.975
Rv1436gap0.972
Rv3010cpfkA0.972
Rv1436gap0.972
Rv1445cdevB0.963
Rv1438tpi0.96
Rv1122gnd20.958
Rv1122gnd20.958
Rv1099cglpX0.941
Rv0363cfba0.939
Rv1437pgk0.938
Rv0478deoC0.936
Rv3068cpgmA0.923
Rv3068cpgmA0.923
Rv3068cpgmA0.923
Rv3068cpgmA0.923
Rv2029cpfkB0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
D-fructose 6-phosphatePubChem0.9260.136
D-fructose-6-phosphatePubChem0.9260.136
ribulose 5-phosphatePubChem0.9230.11
D-erythrose 4-phosphatePubChem0.9200.084
erythrose 4-phosphatePubChem0.9200.084
D-xylulose 5-phosphatePubChem0.9230.11
D-glyceraldehyde-3-phosphatePubChem0.9170.058
sedoheptulose 7-phosphatePubChem0.9290.162
glyceraldehyde-3-phosphatePubChem0.9170.058
D-ribose 5-phosphatePubChem0.9230.11
sedoheptulose-7-phosphatePubChem0.9290.162
heptulose 7-phosphatePubChem0.9290.162
hydron sulfatePubChem0.702196.157
sulfatePubChem0.70296.0626
ethylene glycol; hydronPubChem0.70163.0758
selenomethioninePubChem0.701196.106
chloridePubChem0.70135.453
SeMetPubChem0.701196.106
polyethylene glycolPubChem0.70162.0678