Rv1122

Tuberculist information
Gene namegnd2
Protein functionProbable 6-phosphogluconate dehydrogenase, decarboxylating Gnd2
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1245.13
Molecular mass(da)36358.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 340
	  		  	1    MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGEDRTTGVASLRELSQRLSA   60
			  	61   PRVVWVMVPAGNITTAVIEELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCG  120
			  	121  TSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGVAAAPRTPGRDGEVAPSEQGYLHC  180
			  	181  GPCGSGHFVKMVHNGIEYGMMASLAEGLNILRNADVGTRVQHGDAETAPLPNPECYQYDF  240
			  	241  DIPEVAEVWRRGSVIGSWLLDLTAIALRESPDLAEFSGRVSDSGEGRWTAIAAIDEGVPA  300
			  	301  PVLTTALQSRFASRDLDDFANKALSAMRKQFGGHAEKPAN

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 1 to 161  |  Coverage: 47% NAD_binding_2 Range: 186 to 222  |  Coverage: 10% 6PGD Range: 232 to 337  |  Coverage: 30% 6PGD Range: 3 to 318  |  Coverage: 92% 1 Range: 1 to 161  |  Coverage: 47% 1
Number of amino acids : 340
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NAD_binding_2PF034461-161
6PGDPF00393186-222
6PGDPF00393232-337
Mtb Structural Proteome models
Model Number1
Model nameRv1122
Template2PGD    APDBCREDO
Template coverage5_295
Template Identity(%)35.7
Model coverage(%)92.6
Normalized DOPE score0.12

Structure Models from Chopin
Model Number1
Profilec.2.1.6
Click for model details
zscore12.1
Residue begin1
Residue end161
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1122Gene nameConfidence Score
Rv1445cdevB0.989
Rv1121zwf10.983
Rv1121zwf10.983
Rv2465crpiB0.969
Rv1448ctal0.958
Rv1408rpe0.958
Rv1447czwf20.946
Rv1447czwf20.946
Rv1449ctkt0.937
Rv1449ctkt0.937
Rv1449ctkt0.937
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
6-phosphogluconatePubChem0.964276.135
ribulose-5-phosphatePubChem0.934230.11
ribulose 5-phosphatePubChem0.931230.11
D-ribose 5-phosphatePubChem0.9230.11
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
hydroxyl radicalsPubChem0.917.0073
D-xylulose 5-phosphatePubChem0.9230.11
carbon dioxidePubChem0.944.0095
6-phosphoglucono-delta-lactonePubChem0.9258.12