Rv1408

Tuberculist information
Gene namerpe
Protein functionProbable ribulose-phosphate 3-epimerase Rpe (PPE) (R5P3E) (pentose-5-phosphate 3-epimerase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1584.5
Molecular mass(da)24073.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 232
	  		  	1    VSLMAGSTGGPLIAPSILAADFARLADEAAAVNGADWLHVDVMDGHFVPNLTIGLPVVES   60
			  	61   LLAVTDIPMDCHLMIDNPDRWAPPYAEAGAYNVTFHAEATDNPVGVARDIRAAGAKAGIS  120
			  	121  VKPGTPLEPYLDILPHFDTLLVMSVEPGFGGQRFIPEVLSKVRAVRKMVDAGELTILVEI  180
			  	181  DGGINDDTIEQAAEAGVDCFVAGSAVYGADDPAAAVAALRRQAGAASLHLSL

Known structures in the PDB
No Known structures
1 24 47 70 93 116 139 162 185 208 231 Range: 9 to 207  |  Coverage: 85% Ribul_P_3_epim Range: 12 to 225  |  Coverage: 91% 1 Range: 1 to 230  |  Coverage: 98% 1
Number of amino acids : 232
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribul_P_3_epimPF008349-207
Mtb Structural Proteome models
Model Number1
Model nameRv1408
Template1H1Y    APDBCREDO
Template coverage7_222
Template Identity(%)49.1
Model coverage(%)91.4
Normalized DOPE score-1.198

Structure Models from Chopin
Model Number1
Profilec.1.2.2 - 3.20.20.70
Click for model details
zscore47.54
Residue begin1
Residue end230
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1408Gene nameConfidence Score
Rv1449ctkt0.998
Rv1449ctkt0.998
Rv1449ctkt0.998
Rv1844cgnd10.993
Rv1844cgnd10.993
Rv2465crpiB0.987
Rv1406fmt0.984
Rv1406fmt0.984
Rv2192ctrpD0.967
Rv2192ctrpD0.967
Rv1122gnd20.958
Rv1122gnd20.958
Rv1409ribG0.958
Rv1409ribG0.958
Rv1407fmu0.95
Rv1407fmu0.95
Rv1437pgk0.943
Rv1389gmk0.929
Rv1611trpC0.927
Rv3336ctrpS0.924
Rv0946cpgi0.922
Rv1017cprsA0.921
Rv1017cprsA0.921
Rv2539caroK0.919
Rv1436gap0.915
Rv2447cfolC0.915
Rv2447cfolC0.915
Rv1436gap0.915
Rv0013trpG0.912
Rv1447czwf20.911
Rv1447czwf20.911
Rv1099cglpX0.911
Rv2445cndkA0.909
Rv1609trpE0.908
Rv1609trpE0.908
Rv2783cgpsI0.907
Rv2538caroB0.907
Rv2783cgpsI0.907
Rv2783cgpsI0.907
Rv2783cgpsI0.907
Rv2783cgpsI0.907
Rv1392metK0.904
Rv1617pykA0.904
Rv1392metK0.904
Rv1617pykA0.904
Rv1392metK0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
ribulose-5-phosphatePubChem0.981230.11
ribulose 5-phosphatePubChem0.981230.11
D-xylulose 5-phosphatePubChem0.967230.11
D-ribose 5-phosphatePubChem0.951230.11
sedoheptulose-7-phosphatePubChem0.948290.162
D-glyceraldehyde-3-phosphatePubChem0.943170.058
carbon dioxidePubChem0.90844.0095
heptulose 7-phosphatePubChem0.9290.162
6-phosphogluconatePubChem0.9276.135
glyceraldehyde-3-phosphatePubChem0.9170.058
xylitol-5-phosphatePubChem0.858232.126
polyribosylribitolphosphatePubChem0.852232.126
zincPubChem0.81165.409
phosphatePubChem0.73696.9872
ribose 5-phosphatePubChem0.701230.11
ribulosePubChem0.7150.13