Rv1409

Tuberculist information
Gene nameribG
Protein functionProbable bifunctional riboflavin biosynthesis protein RibG : diaminohydroxyphosphoribosylaminopyrimidine deaminase (riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino) uracil reductase (HTP reductase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1585.19
Molecular mass(da)35366.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 339
	  		  	1    MNVEQVKSIDEAMGLAIEHSYQVKGTTYPKPPVGAVIVDPNGRIVGAGGTEPAGGDHAEV   60
			  	61   VALRRAGGLAAGAIVVVTMEPCNHYGKTPPCVNALIEARVGTVVYAVADPNGIAGGGAGR  120
			  	121  LSAAGLQVRSGVLAEQVAAGPLREWLHKQRTGLPHVTWKYATSIDGRSAAADGSSQWISS  180
			  	181  EAARLDLHRRRAIADAILVGTGTVLADDPALTARLADGSLAPQQPLRVVVGKRDIPPEAR  240
			  	241  VLNDEARTMMIRTHEPMEVLRALSDRTDVLLEGGPTLAGAFLRAGAINRILAYVAPILLG  300
			  	301  GPVTAVDDVGVSNITNALRWQFDSVEKVGPDLLLSLVAR

Known structures in the PDB
No Known structures
1 34 67 100 133 166 199 232 265 298 331 Range: 6 to 107  |  Coverage: 29% dCMP_cyt_deam_1 Range: 154 to 334  |  Coverage: 53% RibD_C Range: 8 to 338  |  Coverage: 97% 1 Range: 8 to 339  |  Coverage: 97% 1 Range: 151 to 339  |  Coverage: 55% 2 Range: 1 to 159  |  Coverage: 46% 3
Number of amino acids : 339
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
dCMP_cyt_deam_1PF003836-107
RibD_CPF01872154-334
Mtb Structural Proteome models
Model Number1
Model nameRv1409
Template2B3Z    APDBCREDO
Template coverage1_358
Template Identity(%)40.2
Model coverage(%)97.3
Normalized DOPE score0.198

Structure Models from Chopin
Model Number1
Profilec.71.1.2, c.97.1.2
Click for model details
zscore57.51
Residue begin8
Residue end339
Model Number2
Profilec.71.1.2
Click for model details
zscore25.12
Residue begin151
Residue end339
Model Number3
Profilec.97.1.2 - 3.40.140.10
Click for model details
zscore18.43
Residue begin1
Residue end159
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1409Gene nameConfidence Score
Rv1415ribA20.999
Rv1415ribA20.999
Rv1416ribH0.998
Rv1940ribA10.997
Rv1940ribA10.997
Rv1412ribC0.985
Rv1408rpe0.958
Rv2786cribF0.955
Rv2786cribF0.955
Rv2671ribD0.941
Rv2533cnusB0.935
Rv2977cthiL0.924
Rv2977cthiL0.924
Rv0189cilvD0.913
Rv2718cnrdR0.905
Rv1391dfp0.902
Rv1391dfp0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NADPPubChem0.977744.413
NADP(H)PubChem0.977745.421
5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedionePubChem0.929276.247
deuteriumPubChem0.9072.01588
H(+)PubChem0.9072.01588
phosphatePubChem0.90396.9872
CPD-1086PubChem0.9354.211
ammoniaPubChem0.917.0305
hydroxyl radicalsPubChem0.917.0073
C04454PubChem0.9356.226
pyrophosphatePubChem0.9177.975
C01304PubChem0.9353.226
protiumPubChem0.92.01576
formatePubChem0.945.0174
C01268PubChem0.9354.211
5-amino-2,6-dioxo-4-ribitylaminopyrimidinePubChem0.9276.247
guanosine triphosphatePubChem0.9523.18
zincPubChem0.79265.409
SeMetPubChem0.792196.106
selenomethioninePubChem0.792196.106
riboflavinPubChem0.775376.364