Rv2533c

Tuberculist information
Gene namenusB
Protein functionN utilization substance protein NusB (NusB protein)
Functional category(tuberculist)information pathways
Gene location(kb)2858.25
Molecular mass(da)16740.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 156
	  		  	1    MSDRKPVRGRHQARKRAVALLFEAEVRGISAAEVVDTRAALAEAKPDIARLHPYTAAVAR   60
			  	61   GVSEHAAHIDDLITAHLRGWTLDRLPAVDRAILRVSVWELLHAADVPEPVVVDEAVQLAK  120
			  	121  ELSTDDSPGFVNGVLGQVMLVTPQLRAAAQAVRGGA

Known structures in the PDB
PDB ID1EYV
Total residue count312
Number of chains2
MethodX-RAY
Resolution1.6
1 16 31 46 61 76 91 106 121 136 151 Range: 11 to 139  |  Coverage: 82% NusB Range: 9 to 139  |  Coverage: 83% 1 Range: 9 to 139  |  Coverage: 83% 2 Range: 4 to 149  |  Coverage: 92% 1
Number of amino acids : 156
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NusBPF0102911-139
Mtb Structural Proteome models
Model Number1
Model nameRv2533c_1eyv_A
Template1EYV    APDBCREDO
Template coverage9_139
Template Identity(%)100.0
Model coverage(%)83.3
Normalized DOPE score-2.361

Model Number2
Model nameRv2533c
Template1EYV    APDBCREDO
Template coverage9_139
Template Identity(%)100.0
Model coverage(%)83.3
Normalized DOPE score-1.922

Structure Models from Chopin
Model Number1
Profilea.79.1.1 - 1.10.940.10
Click for model details
zscore28.35
Residue begin4
Residue end149
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2533cGene nameConfidence Score
Rv0700rpsJ0.998
Rv0639nusG0.988
Rv0639nusG0.988
Rv2534cefp0.984
Rv2534cefp0.984
Rv2534cefp0.984
Rv1416ribH0.983
Rv3356cfolD0.969
Rv3356cfolD0.969
Rv1108cxseA0.968
Rv1108cxseA0.968
Rv2535cpepQ0.965
Rv2535cpepQ0.965
Rv2532cRv2532c0.965
Rv0667rpoB0.945
Rv0667rpoB0.945
Rv0667rpoB0.945
Rv0667rpoB0.945
Rv0667rpoB0.945
Rv0667rpoB0.945
Rv1409ribG0.935
Rv1409ribG0.935
Rv1694tlyA0.931
Rv1694tlyA0.931
Rv1696recN0.923
Rv3336ctrpS0.92
Rv1713engA0.909
Rv1713engA0.909
Rv1412ribC0.908
Rv2977cthiL0.906
Rv2977cthiL0.906
Rv2555calaS0.903
Rv2555calaS0.903
Rv2555calaS0.903
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv2533c_1eyv_A11aj6_NOV_A_1PDBCREDO0.5380.2610.5380.006
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
phosphatePubChem0.996.9872
hydron diphosphatePubChem0.9391.981
substance BPubChem0.715672.716