Rv0700

Tuberculist information
Gene namerpsJ
Protein function30S ribosomal protein S10 RpsJ (transcription antitermination factor NusE)
Functional category(tuberculist)information pathways
Gene location(kb)800.487
Molecular mass(da)11399.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 101
	  		  	1    VAGQKIRIRLKAYDHEAIDASARKIVETVVRTGASVVGPVPLPTEKNVYCVIRSPHKYKD   60
			  	61   SREHFEMRTHKRLIDIIDPTPKTVDALMRIDLPASVDVNIQ

Known structures in the PDB
No Known structures
1 11 21 31 41 51 61 71 81 91 101 Range: 6 to 101  |  Coverage: 94% Ribosomal_S10 Range: 5 to 100  |  Coverage: 94% 1 Range: 5 to 101  |  Coverage: 95% 1
Number of amino acids : 101
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribosomal_S10PF003386-101
Mtb Structural Proteome models
Model Number1
Model nameRv0700
Template2AVY    JPDBCREDO
Template coverage5_100
Template Identity(%)61.5
Model coverage(%)94.1
Normalized DOPE score-0.042

Structure Models from Chopin
Model Number1
Profiled.58.15.1 - 3.30.70.600
Click for model details
zscore23.8
Residue begin5
Residue end101
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0700Gene nameConfidence Score
Rv0721rpsE0.999
Rv0702rplD0.999
Rv3442crpsI0.999
Rv0721rpsE0.999
Rv3459crpsK0.999
Rv0710rpsQ0.999
Rv3460crpsM0.999
Rv0705rpsS0.999
Rv2533cnusB0.998
Rv0701rplC0.998
Rv0707rpsC0.998
Rv0707rpsC0.998
Rv3458crpsD0.998
Rv0703rplW0.998
Rv0682rpsL0.998
Rv3458crpsD0.998
Rv0704rplB0.998
Rv0683rpsG0.998
Rv0704rplB0.998
Rv0718rpsH0.998
Rv0706rplV0.997
Rv2890crpsB0.997
Rv3443crplM0.997
Rv0708rplP0.997
Rv0717rpsN10.997
Rv0685tuf0.997
Rv0639nusG0.997
Rv0685tuf0.997
Rv0639nusG0.997
Rv0685tuf0.997
Rv0667rpoB0.996
Rv0714rplN0.996
Rv0640rplK0.996
Rv0667rpoB0.996
Rv0640rplK0.996
Rv0667rpoB0.996
Rv0716rplE0.996
Rv0667rpoB0.996
Rv0716rplE0.996
Rv0651rplJ0.996
Rv0667rpoB0.996
Rv0667rpoB0.996
Rv0719rplF0.996
Rv0641rplA0.995
Rv0684fusA10.994
Rv0684fusA10.994
Rv0684fusA10.994
Rv0684fusA10.994
Rv0709rpmC0.994
Rv0723rplO0.994
Rv0684fusA10.994
Rv3457crpoA0.993
Rv3457crpoA0.993
Rv2056crpsN20.993
Rv2785crpsO0.993
Rv0652rplL0.993
Rv3457crpoA0.993
Rv0720rplR0.992
Rv0715rplX0.992
Rv3456crplQ0.992
Rv0053rpsF0.991
Rv0732secY0.991
Rv0668rpoC0.99
Rv0668rpoC0.99
Rv0668rpoC0.99
Rv0668rpoC0.99
Rv0668rpoC0.99
Rv1641infC0.989
Rv1641infC0.989
Rv2909crpsP0.988
Rv2412rpsT0.987
Rv0722rpmD0.986
Rv2889ctsf0.985
Rv2882cfrr0.985
Rv2889ctsf0.985
Rv0734mapA0.977
Rv2442crplU0.972
Rv3461crpmJ0.971
Rv2534cefp0.971
Rv2534cefp0.971
Rv2534cefp0.971
Rv2861cmapB0.97
Rv2904crplS0.969
Rv0120cfusA20.965
Rv0120cfusA20.965
Rv0120cfusA20.965
Rv0120cfusA20.965
Rv0120cfusA20.965
Rv1630rpsA0.964
Rv3100csmpB0.963
Rv1643rplT0.962
Rv0056rplI0.96
Rv0056rplI0.96
Rv2441crpmA0.959
Rv0733adk0.949
Rv0634BrpmG20.947
Rv3455ctruA0.947
Rv3462cinfA0.946
Rv0055rpsR10.945
Rv2906ctrmD0.94
Rv2883cpyrH0.938
Rv2448cvalS0.932
Rv2448cvalS0.932
Rv2448cvalS0.932
Rv1023eno0.931
Rv1023eno0.931
Rv2839cinfB0.93
Rv2839cinfB0.93
Rv2839cinfB0.93
Rv2839cinfB0.93
Rv1308atpA0.922
Rv1308atpA0.922
Rv1308atpA0.922
Rv1298rpmE0.92
Rv1299prfA0.915
Rv1299prfA0.915
Rv1292argS0.913
Rv1292argS0.913
Rv1292argS0.913
Rv3105cprfB0.907
Rv3105cprfB0.907
Rv2462ctig0.906
Rv2462ctig0.906
Rv2462ctig0.906
Rv1649pheS0.903
Rv1649pheS0.903
Rv1297rho0.902
Rv1297rho0.902
Rv1297rho0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00698DrugBankNitrofurantoin
DB01421DrugBankParomomycin
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
kirromycinPubChem0.888796.943
magnesiumPubChem0.82924.305
guanosine diphosphatePubChem0.789443.201
spectinomycinPubChem0.789332.35
substance BPubChem0.757672.716
zincPubChem0.71865.409
7mgPubChem0.708379.263
methyl 4-[3-[3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]-4,6-dimethyl-9-oxoimidazo[1,2-a]purin-PubChem0.708588.462
[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl phosphatePubChem0.708338.208
2'-O-methylguanosine 5'-monophosphatePubChem0.708377.247
potassiumPubChem0.70839.0983
L-2,3-diaminopropionic acidPubChem0.708104.108
[3,4-dihydroxy-5-(2-methylamino-6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.708377.247
streptomycinPubChem0.708581.574
3'-phosphoadenosine 5'-phosphatePubChem0.708427.201
poly(2'-O-methylcytidylic acid)PubChem0.708337.223
pseudouridylic acidPubChem0.708324.181
L-beta-lysinePubChem0.708146.188
poly CPubChem0.708323.197
[3,4-dihydroxy-5-(6-imino-1-methyl-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.708361.248
C04639PubChem0.708326.197
2-mercaptoethanolPubChem0.70878.1334
CHEBI:603702PubChem0.708558.623
poly(2'-O-methyladenylic acid)PubChem0.708361.248
beta-lysinePubChem0.708146.188
CSIPubChem0.708172.185
phenylalaninalPubChem0.708149.19
fusidic acidPubChem0.708516.709
[(2R,3S,4R,5R)-5-[2-(dimethylamino)-6-oxo-3H-purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen PubChem0.708391.274
ara-TMPPubChem0.708338.208
guanylatePubChem0.708363.221
potassium hydridePubChem0.70840.1062
UD29PubChem0.708340.247
guanylyl-(alpha,beta)-methylene-diphosphonatePubChem0.708521.208
C07026PubChem0.708346.236
5-methylcytidylic acidPubChem0.708337.223
adenosine 3',5'-diphosphatePubChem0.708427.201
pactamycinPubChem0.708558.623
adenosine monophosphatePubChem0.708347.221
[5-(2-dimethylamino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic AcidPubChem0.708391.274
polyuridylic acidPubChem0.708324.181
pseudouridine 5'-phosphatePubChem0.708324.181
kasugamycinPubChem0.708379.363
2,3-diaminopropionic acidPubChem0.708104.108
DB08185PubChem0.708463.446
3'-amino-3'-deoxy AMPPubChem0.708346.236
MYC-8003PubChem0.708796.943
(4S)-albaflavenolPubChem0.704220.35