Rv3458c

Tuberculist information
Gene namerpsD
Protein function30S ribosomal protein S4 RpsD
Functional category(tuberculist)information pathways
Gene location(kb)3878.66
Molecular mass(da)23475.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 201
	  		  	1    MARYTGPVTRKSRRLRTDLVGGDQAFEKRPYPPGQHGRARIKESEYLLQLQEKQKARFTY   60
			  	61   GVMEKQFRRYYEEAVRQPGKTGEELLKILESRLDNVIYRAGLARTRRMARQLVSHGHFNV  120
			  	121  NGVHVNVPSYRVSQYDIVDVRDKSLNTVPFQIARETAGERPIPSWLQVVGERQRVLIHQL  180
			  	181  PERAQIDVPLTEQLIVEYYSK

Known structures in the PDB
No Known structures
1 21 41 61 81 101 121 141 161 181 201 Range: 2 to 90  |  Coverage: 43% Ribosomal_S4 Range: 91 to 138  |  Coverage: 23% S4 Range: 2 to 201  |  Coverage: 99% 1 Range: 2 to 201  |  Coverage: 99% 1 Range: 1 to 105  |  Coverage: 51% 2
Number of amino acids : 201
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribosomal_S4PF001632-90
S4PF0147991-138
Mtb Structural Proteome models
Model Number1
Model nameRv3458c
Template2AVY    DPDBCREDO
Template coverage1_205
Template Identity(%)47.5
Model coverage(%)99.0
Normalized DOPE score-0.675

Structure Models from Chopin
Model Number1
Profiled.66.1.2
Click for model details
zscore49.57
Residue begin2
Residue end201
Model Number2
Profile1.10.1050.10
Click for model details
zscore24.86
Residue begin1
Residue end105
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3458cGene nameConfidence Score
Rv0707rpsC0.999
Rv0707rpsC0.999
Rv0682rpsL0.999
Rv3459crpsK0.999
Rv0683rpsG0.999
Rv3460crpsM0.999
Rv0718rpsH0.999
Rv3457crpoA0.998
Rv3457crpoA0.998
Rv0721rpsE0.998
Rv3457crpoA0.998
Rv0721rpsE0.998
Rv3442crpsI0.998
Rv0710rpsQ0.998
Rv0705rpsS0.998
Rv0700rpsJ0.998
Rv0641rplA0.997
Rv0685tuf0.997
Rv0685tuf0.997
Rv0685tuf0.997
Rv0701rplC0.996
Rv0716rplE0.996
Rv0716rplE0.996
Rv0717rpsN10.996
Rv3456crplQ0.996
Rv0706rplV0.995
Rv0702rplD0.995
Rv0708rplP0.995
Rv0704rplB0.995
Rv0704rplB0.995
Rv0703rplW0.994
Rv0640rplK0.993
Rv0668rpoC0.993
Rv2890crpsB0.993
Rv0668rpoC0.993
Rv2056crpsN20.993
Rv0651rplJ0.993
Rv0668rpoC0.993
Rv0668rpoC0.993
Rv0640rplK0.993
Rv0668rpoC0.993
Rv0719rplF0.993
Rv0684fusA10.992
Rv0720rplR0.992
Rv0684fusA10.992
Rv0684fusA10.992
Rv2441crpmA0.992
Rv0684fusA10.992
Rv0723rplO0.992
Rv0684fusA10.992
Rv0714rplN0.992
Rv0667rpoB0.991
Rv0667rpoB0.991
Rv0667rpoB0.991
Rv0667rpoB0.991
Rv0667rpoB0.991
Rv0667rpoB0.991
Rv0715rplX0.99
Rv3443crplM0.99
Rv0732secY0.99
Rv0053rpsF0.989
Rv2785crpsO0.988
Rv0652rplL0.987
Rv1641infC0.985
Rv1641infC0.985
Rv0722rpmD0.984
Rv3100csmpB0.98
Rv0709rpmC0.98
Rv0733adk0.979
Rv2904crplS0.977
Rv0639nusG0.977
Rv0639nusG0.977
Rv1023eno0.974
Rv1023eno0.974
Rv2909crpsP0.974
Rv3462cinfA0.973
Rv2889ctsf0.97
Rv2889ctsf0.97
Rv1630rpsA0.969
Rv0056rplI0.968
Rv0056rplI0.968
Rv1297rho0.967
Rv1297rho0.967
Rv1297rho0.967
Rv0734mapA0.96
Rv2882cfrr0.959
Rv2442crplU0.958
Rv2412rpsT0.956
Rv2906ctrmD0.956
Rv0055rpsR10.955
Rv3455ctruA0.955
Rv1643rplT0.954
Rv1298rpmE0.95
Rv2861cmapB0.949
Rv2534cefp0.945
Rv2534cefp0.945
Rv2534cefp0.945
Rv1299prfA0.937
Rv1299prfA0.937
Rv3461crpmJ0.935
Rv2555calaS0.932
Rv2555calaS0.932
Rv2555calaS0.932
Rv2839cinfB0.93
Rv2839cinfB0.93
Rv2839cinfB0.93
Rv2839cinfB0.93
Rv1649pheS0.927
Rv1649pheS0.927
Rv2916cffh0.921
Rv2916cffh0.921
Rv2916cffh0.921
Rv2580chisS0.918
Rv2580chisS0.918
Rv2841cnusA0.917
Rv2841cnusA0.917
Rv2462ctig0.913
Rv2462ctig0.913
Rv2462ctig0.913
Rv2783cgpsI0.912
Rv2783cgpsI0.912
Rv2783cgpsI0.912
Rv2783cgpsI0.912
Rv2783cgpsI0.912
Rv1292argS0.909
Rv1292argS0.909
Rv1292argS0.909
Rv1699pyrG0.908
Rv1699pyrG0.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00254DrugBankDoxycycline
DB00256DrugBankLymecycline
DB00453DrugBankClomocycline
DB00595DrugBankOxytetracycline
DB00618DrugBankDemeclocycline
DB01017DrugBankMinocycline
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
streptomycinPubChem0.871581.574
magnesiumPubChem0.79624.305
spectinomycinPubChem0.787332.35
guanosine diphosphatePubChem0.787443.201
kasugamycinPubChem0.782379.363
polyuridylic acidPubChem0.762324.181
zincPubChem0.71465.409
coniothyrionePubChem0.711310.687
poly(2'-O-methyladenylic acid)PubChem0.701361.248
beta-lysinePubChem0.701146.188
methyl 4-[3-[3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]-4,6-dimethyl-9-oxoimidazo[1,2-a]purin-PubChem0.701588.462
fusidic acidPubChem0.701516.709
[(2R,3S,4R,5R)-5-[2-(dimethylamino)-6-oxo-3H-purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen PubChem0.701391.274
ara-TMPPubChem0.701338.208
guanylatePubChem0.701363.221
potassium hydridePubChem0.70140.1062
[3,4-dihydroxy-5-(2-methylamino-6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.701377.247
guanylyl-(alpha,beta)-methylene-diphosphonatePubChem0.701521.208
C07026PubChem0.701346.236
5-methylcytidylic acidPubChem0.701337.223
adenosine 3',5'-diphosphatePubChem0.701427.201
[3,4-dihydroxy-5-(6-imino-1-methyl-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.701361.248
pactamycinPubChem0.701558.623
adenosine monophosphatePubChem0.701347.221
C04639PubChem0.701326.197
pseudouridine 5'-phosphatePubChem0.701324.181
CSIPubChem0.701172.185
2,3-diaminopropionic acidPubChem0.701104.108
phenylalaninalPubChem0.701149.19
MYC-8003PubChem0.701796.943
7mgPubChem0.701379.263
UD29PubChem0.701340.247
kirromycinPubChem0.701796.943
[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl phosphatePubChem0.701338.208
2'-O-methylguanosine 5'-monophosphatePubChem0.701377.247
potassiumPubChem0.70139.0983
L-2,3-diaminopropionic acidPubChem0.701104.108
[5-(2-dimethylamino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic AcidPubChem0.701391.274
3'-phosphoadenosine 5'-phosphatePubChem0.701427.201
poly(2'-O-methylcytidylic acid)PubChem0.701337.223
pseudouridylic acidPubChem0.701324.181
L-beta-lysinePubChem0.701146.188
DB08185PubChem0.701463.446
poly CPubChem0.701323.197
3'-amino-3'-deoxy AMPPubChem0.701346.236
2-mercaptoethanolPubChem0.70178.1334
CHEBI:603702PubChem0.701558.623