Rv2906c

Tuberculist information
Gene nametrmD
Protein functionProbable tRNA (guanine-N1)-methyltransferase TrmD (M1G-methyltransferase) (tRNA [GM37] methyltransferase)
Functional category(tuberculist)information pathways
Gene location(kb)3215.67
Molecular mass(da)25134.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 230
	  		  	1    VRIDIVTIFPACLDPLRQSLPGKAIESGLVDLNVHDLRRWTHDVHHSVDDAPYGGGPGMV   60
			  	61   MKAPVWGEALDEICSSETLLIVPTPAGVLFTQATAQRWTTESHLVFACGRYEGIDQRVVQ  120
			  	121  DAARRMRVEEVSIGDYVLPGGESAAVVMVEAVLRLLAGVLGNPASHQDDSHSTGLDGLLE  180
			  	181  GPSYTRPASWRGLDVPEVLLSGDHARIAAWRREVSLQRTRERRPDLSHPD

Known structures in the PDB
No Known structures
1 24 47 70 93 116 139 162 185 208 231 Range: 21 to 224  |  Coverage: 88% tRNA_m1G_MT Range: 1 to 227  |  Coverage: 98% 1 Range: 1 to 230  |  Coverage: 99% 1 Range: 173 to 230  |  Coverage: 24% 2
Number of amino acids : 230
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
tRNA_m1G_MTPF0174621-224
Mtb Structural Proteome models
Model Number1
Model nameRv2906c
Template1UAL    APDBCREDO
Template coverage1_224
Template Identity(%)40.9
Model coverage(%)98.3
Normalized DOPE score-0.004

Structure Models from Chopin
Model Number1
Profilec.116.1.4
Click for model details
zscore46.09
Residue begin1
Residue end230
Model Number2
Profile1.10.1270.20
Click for model details
zscore19.07
Residue begin173
Residue end230
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2906cGene nameConfidence Score
Rv2909crpsP0.999
Rv2907crimM0.998
Rv2904crplS0.998
Rv2907crimM0.998
Rv2916cffh0.989
Rv2916cffh0.989
Rv2916cffh0.989
Rv2727cmiaA0.983
Rv1010ksgA0.982
Rv3457crpoA0.979
Rv3457crpoA0.979
Rv3457crpoA0.979
Rv3460crpsM0.977
Rv1406fmt0.974
Rv1406fmt0.974
Rv3456crplQ0.974
Rv3459crpsK0.967
Rv0706rplV0.966
Rv2992cgltS0.966
Rv0208cRv0208c0.965
Rv0682rpsL0.963
Rv0667rpoB0.961
Rv0667rpoB0.961
Rv0667rpoB0.961
Rv0667rpoB0.961
Rv0667rpoB0.961
Rv0667rpoB0.961
Rv2793ctruB0.96
Rv2793ctruB0.96
Rv2908cRv2908c0.959
Rv3443crplM0.959
Rv2441crpmA0.959
Rv2442crplU0.959
Rv2925crnc0.958
Rv2925crnc0.958
Rv3458crpsD0.956
Rv3458crpsD0.956
Rv0704rplB0.956
Rv0704rplB0.956
Rv2783cgpsI0.955
Rv0703rplW0.955
Rv2783cgpsI0.955
Rv2783cgpsI0.955
Rv2783cgpsI0.955
Rv0705rpsS0.955
Rv2783cgpsI0.955
Rv0640rplK0.953
Rv0640rplK0.953
Rv3442crpsI0.949
Rv0723rplO0.949
Rv2889ctsf0.949
Rv0732secY0.949
Rv2889ctsf0.949
Rv0701rplC0.948
Rv0716rplE0.948
Rv0716rplE0.948
Rv0641rplA0.948
Rv0714rplN0.947
Rv0707rpsC0.946
Rv0707rpsC0.946
Rv0708rplP0.946
Rv0719rplF0.946
Rv0702rplD0.944
Rv2890crpsB0.944
Rv2785crpsO0.943
Rv0683rpsG0.94
Rv0700rpsJ0.94
Rv0718rpsH0.938
Rv0710rpsQ0.937
Rv1298rpmE0.936
Rv0684fusA10.931
Rv0684fusA10.931
Rv0684fusA10.931
Rv0684fusA10.931
Rv0720rplR0.931
Rv0684fusA10.931
Rv1299prfA0.929
Rv3024ctrmU0.929
Rv1299prfA0.929
Rv0639nusG0.928
Rv0639nusG0.928
Rv0652rplL0.927
Rv0685tuf0.927
Rv0685tuf0.927
Rv0685tuf0.927
Rv3646ctopA0.925
Rv3646ctopA0.925
Rv0715rplX0.925
Rv3646ctopA0.925
Rv3455ctruA0.924
Rv1641infC0.924
Rv1641infC0.924
Rv2921cftsY0.922
Rv2921cftsY0.922
Rv0721rpsE0.917
Rv0651rplJ0.917
Rv0721rpsE0.917
Rv3581cispF0.912
Rv3419cgcp0.912
Rv2753cdapA0.91
Rv2839cinfB0.902
Rv2839cinfB0.902
Rv2839cinfB0.902
Rv2839cinfB0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
S-adenosyl-L-methioninePubChem0.885399.445
S-adenosylhomocysteinePubChem0.831384.411
phosphatePubChem0.72396.9872
cysteic acidPubChem0.701169.156
cysteatePubChem0.701169.156
hydron diphosphatePubChem0.7391.981