Rv3442c

Tuberculist information
Gene namerpsI
Protein function30S ribosomal protein S9 RpsI
Functional category(tuberculist)information pathways
Gene location(kb)3861.5
Molecular mass(da)16436
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 151
	  		  	1    MTETTPAPQTPAAPAGPAQSFVLERPIQTVGRRKEAVVRVRLVPGTGKFDLNGRSLEDYF   60
			  	61   PNKVHQQLIKAPLVTVDRVESFDIFAHLGGGGPSGQAGALRLGIARALILVSPEDRPALK  120
			  	121  KAGFLTRDPRATERKKYGLKKARKAPQYSKR

Known structures in the PDB
No Known structures
1 16 31 46 61 76 91 106 121 136 151 Range: 31 to 151  |  Coverage: 79% Ribosomal_S9 Range: 31 to 151  |  Coverage: 79% 1 Range: 7 to 151  |  Coverage: 95% 1
Number of amino acids : 151
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribosomal_S9PF0038031-151
Mtb Structural Proteome models
Model Number1
Model nameRv3442c
Template1FJG    IPDBCREDO
Template coverage8_128
Template Identity(%)54.5
Model coverage(%)78.9
Normalized DOPE score-0.46

Structure Models from Chopin
Model Number1
Profiled.14.1.1 - 3.30.230.10
Click for model details
zscore22.81
Residue begin7
Residue end151
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3442cGene nameConfidence Score
Rv0707rpsC0.999
Rv0721rpsE0.999
Rv0707rpsC0.999
Rv3443crplM0.999
Rv3459crpsK0.999
Rv2890crpsB0.999
Rv0700rpsJ0.999
Rv0721rpsE0.999
Rv3458crpsD0.998
Rv3458crpsD0.998
Rv0718rpsH0.998
Rv3460crpsM0.998
Rv0714rplN0.998
Rv0705rpsS0.998
Rv0682rpsL0.997
Rv0683rpsG0.997
Rv0704rplB0.997
Rv0710rpsQ0.997
Rv0704rplB0.997
Rv0702rplD0.996
Rv0716rplE0.996
Rv0719rplF0.996
Rv0716rplE0.996
Rv2889ctsf0.995
Rv0708rplP0.995
Rv2889ctsf0.995
Rv0701rplC0.995
Rv2441crpmA0.993
Rv2785crpsO0.992
Rv0706rplV0.992
Rv3456crplQ0.991
Rv2882cfrr0.99
Rv0723rplO0.99
Rv0641rplA0.989
Rv0717rpsN10.989
Rv0651rplJ0.988
Rv0685tuf0.988
Rv0685tuf0.988
Rv0685tuf0.988
Rv0703rplW0.987
Rv1641infC0.987
Rv1641infC0.987
Rv0720rplR0.987
Rv0053rpsF0.986
Rv3457crpoA0.986
Rv0640rplK0.986
Rv3457crpoA0.986
Rv0640rplK0.986
Rv3457crpoA0.986
Rv2412rpsT0.984
Rv2442crplU0.984
Rv0715rplX0.983
Rv2904crplS0.982
Rv0684fusA10.98
Rv0684fusA10.98
Rv0684fusA10.98
Rv0684fusA10.98
Rv0684fusA10.98
Rv2909crpsP0.979
Rv1298rpmE0.979
Rv1643rplT0.978
Rv2534cefp0.976
Rv2534cefp0.976
Rv2534cefp0.976
Rv2056crpsN20.973
Rv0667rpoB0.97
Rv0667rpoB0.97
Rv0667rpoB0.97
Rv0667rpoB0.97
Rv0667rpoB0.97
Rv0667rpoB0.97
Rv2916cffh0.966
Rv0652rplL0.966
Rv2916cffh0.966
Rv2916cffh0.966
Rv0732secY0.962
Rv1023eno0.959
Rv1023eno0.959
Rv2992cgltS0.958
Rv2839cinfB0.955
Rv3455ctruA0.955
Rv2839cinfB0.955
Rv2839cinfB0.955
Rv2839cinfB0.955
Rv0056rplI0.954
Rv0056rplI0.954
Rv3100csmpB0.953
Rv1699pyrG0.951
Rv1699pyrG0.951
Rv0668rpoC0.95
Rv0668rpoC0.95
Rv0668rpoC0.95
Rv0668rpoC0.95
Rv0668rpoC0.95
Rv2906ctrmD0.949
Rv1010ksgA0.945
Rv0055rpsR10.944
Rv0722rpmD0.936
Rv1299prfA0.934
Rv2057crpmG10.934
Rv1299prfA0.934
Rv2462ctig0.933
Rv2462ctig0.933
Rv2462ctig0.933
Rv0634BrpmG20.93
Rv0350dnaK0.927
Rv3336ctrpS0.923
Rv1308atpA0.914
Rv1308atpA0.914
Rv1308atpA0.914
Rv2580chisS0.906
Rv2580chisS0.906
Rv1713engA0.903
Rv1713engA0.903
Rv0357cpurA0.902
Rv0733adk0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00254DrugBankDoxycycline
DB00256DrugBankLymecycline
DB00453DrugBankClomocycline
DB00560DrugBankTigecycline
DB00595DrugBankOxytetracycline
DB00618DrugBankDemeclocycline
DB01017DrugBankMinocycline
DB01301DrugBankRolitetracycline
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
kasugamycinPubChem0.884379.363
magnesiumPubChem0.824.305
spectinomycinPubChem0.787332.35
guanosine diphosphatePubChem0.787443.201
2,3-diaminopropionic acidPubChem0.702104.108
CSIPubChem0.702172.185
phenylalaninalPubChem0.702149.19
MYC-8003PubChem0.702796.943
7mgPubChem0.702379.263
UD29PubChem0.702340.247
kirromycinPubChem0.702796.943
[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl phosphatePubChem0.702338.208
2'-O-methylguanosine 5'-monophosphatePubChem0.702377.247
potassiumPubChem0.70239.0983
L-2,3-diaminopropionic acidPubChem0.702104.108
streptomycinPubChem0.702581.574
3'-phosphoadenosine 5'-phosphatePubChem0.702427.201
[5-(2-dimethylamino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic AcidPubChem0.702391.274
poly(2'-O-methylcytidylic acid)PubChem0.702337.223
pseudouridylic acidPubChem0.702324.181
L-beta-lysinePubChem0.702146.188
zincPubChem0.70265.409
poly CPubChem0.702323.197
DB08185PubChem0.702463.446
3'-amino-3'-deoxy AMPPubChem0.702346.236
2-mercaptoethanolPubChem0.70278.1334
CHEBI:603702PubChem0.702558.623
poly(2'-O-methyladenylic acid)PubChem0.702361.248
beta-lysinePubChem0.702146.188
methyl 4-[3-[3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]-4,6-dimethyl-9-oxoimidazo[1,2-a]purin-PubChem0.702588.462
fusidic acidPubChem0.702516.709
[(2R,3S,4R,5R)-5-[2-(dimethylamino)-6-oxo-3H-purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen PubChem0.702391.274
ara-TMPPubChem0.702338.208
guanylatePubChem0.702363.221
potassium hydridePubChem0.70240.1062
guanylyl-(alpha,beta)-methylene-diphosphonatePubChem0.702521.208
C07026PubChem0.702346.236
[3,4-dihydroxy-5-(2-methylamino-6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.702377.247
5-methylcytidylic acidPubChem0.702337.223
adenosine 3',5'-diphosphatePubChem0.702427.201
pactamycinPubChem0.702558.623
adenosine monophosphatePubChem0.702347.221
[3,4-dihydroxy-5-(6-imino-1-methyl-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.702361.248
C04639PubChem0.702326.197
polyuridylic acidPubChem0.702324.181
pseudouridine 5'-phosphatePubChem0.702324.181