Rv0685

Tuberculist information
Gene nametuf
Protein functionProbable iron-regulated elongation factor TU Tuf (EF-TU)
Functional category(tuberculist)information pathways
Gene location(kb)784.821
Molecular mass(da)43561.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 396
	  		  	1    VAKAKFQRTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKFPDLNETKAFDQIDNAPEERQ   60
			  	61   RGITINIAHVEYQTDKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTRE  120
			  	121  HVLLARQVGVPYILVALNKADAVDDEELLELVEMEVRELLAAQEFDEDAPVVRVSALKAL  180
			  	181  EGDAKWVASVEELMNAVDESIPDPVRETDKPFLMPVEDVFTITGRGTVVTGRVERGVINV  240
			  	241  NEEVEIVGIRPSTTKTTVTGVEMFRKLLDQGQAGDNVGLLLRGVKREDVERGQVVTKPGT  300
			  	301  TTPHTEFEGQVYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTN  360
			  	361  ISVKLIQPVAMDEGLRFAIREGGRTVGAGRVTKIIK

Known structures in the PDB
No Known structures
1 40 79 118 157 196 235 274 313 352 391 Range: 10 to 203  |  Coverage: 48% GTP_EFTU Range: 226 to 296  |  Coverage: 17% GTP_EFTU_D2 Range: 300 to 395  |  Coverage: 23% GTP_EFTU_D3 Range: 9 to 395  |  Coverage: 97% 1 Range: 1 to 396  |  Coverage: 99% 1 Range: 203 to 306  |  Coverage: 26% 2 Range: 300 to 395  |  Coverage: 23% 3 Range: 10 to 203  |  Coverage: 48% 4 Range: 202 to 351  |  Coverage: 37% 5
Number of amino acids : 396
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GTP_EFTUPF0000910-203
GTP_EFTU_D2PF03144226-296
GTP_EFTU_D3PF03143300-395
Mtb Structural Proteome models
Model Number1
Model nameRv0685
Template1EFC    APDBCREDO
Template coverage8_392
Template Identity(%)75.3
Model coverage(%)97.5
Normalized DOPE score-1.108

Structure Models from Chopin
Model Number1
Profileb.43.3.1, b.44.1.1, c.37.1.8 - 2.40.30.10, 3.40.50.300
Click for model details
zscore51.57
Residue begin1
Residue end396
Model Number2
Profileb.43.3.1 - 2.40.30.10
Click for model details
zscore16.51
Residue begin203
Residue end306
Model Number3
Profileb.44.1.1
Click for model details
zscore13.44
Residue begin300
Residue end395
Model Number4
Profilec.37.1.8 - 3.40.50.300
Click for model details
zscore13.32
Residue begin10
Residue end203
Model Number5
Profileb.43.3.1
Click for model details
zscore10.07
Residue begin202
Residue end351
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0685Gene nameConfidence Score
Rv0683rpsG0.999
Rv0682rpsL0.997
Rv0700rpsJ0.997
Rv3458crpsD0.997
Rv3458crpsD0.997
Rv3459crpsK0.996
Rv3460crpsM0.996
Rv0721rpsE0.996
Rv0721rpsE0.996
Rv0704rplB0.995
Rv0718rpsH0.995
Rv0707rpsC0.995
Rv0640rplK0.995
Rv0707rpsC0.995
Rv0640rplK0.995
Rv0704rplB0.995
Rv0716rplE0.993
Rv0716rplE0.993
Rv0705rpsS0.992
Rv0710rpsQ0.991
Rv0702rplD0.991
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv0684fusA10.989
Rv0652rplL0.989
Rv0684fusA10.989
Rv0684fusA10.989
Rv0684fusA10.989
Rv0684fusA10.989
Rv0641rplA0.989
Rv0651rplJ0.988
Rv3442crpsI0.988
Rv3456crplQ0.987
Rv0720rplR0.987
Rv0701rplC0.987
Rv0708rplP0.987
Rv0440groEL20.986
Rv3457crpoA0.986
Rv3457crpoA0.986
Rv3457crpoA0.986
Rv2889ctsf0.986
Rv2889ctsf0.986
Rv0732secY0.983
Rv0719rplF0.983
Rv0714rplN0.983
Rv0053rpsF0.983
Rv0717rpsN10.983
Rv2890crpsB0.983
Rv3417cgroEL10.982
Rv0350dnaK0.98
Rv0639nusG0.979
Rv0639nusG0.979
Rv1310atpD0.977
Rv1310atpD0.977
Rv1310atpD0.977
Rv2785crpsO0.976
Rv0706rplV0.975
Rv2909crpsP0.974
Rv0715rplX0.973
Rv0703rplW0.971
Rv0723rplO0.971
Rv0668rpoC0.969
Rv0668rpoC0.969
Rv0668rpoC0.969
Rv0668rpoC0.969
Rv0668rpoC0.969
Rv2904crplS0.965
Rv3443crplM0.962
Rv1308atpA0.96
Rv1308atpA0.96
Rv1308atpA0.96
Rv2462ctig0.959
Rv2462ctig0.959
Rv2462ctig0.959
Rv3462cinfA0.958
Rv0733adk0.953
Rv2150cftsZ0.947
Rv2150cftsZ0.947
Rv3461crpmJ0.94
Rv0709rpmC0.94
Rv0056rplI0.936
Rv0056rplI0.936
Rv2056crpsN20.933
Rv1309atpG0.929
Rv2906ctrmD0.927
Rv1023eno0.927
Rv1023eno0.927
Rv2783cgpsI0.923
Rv2783cgpsI0.923
Rv2783cgpsI0.923
Rv2783cgpsI0.923
Rv2783cgpsI0.923
Rv3598clysS0.921
Rv3598clysS0.921
Rv0120cfusA20.916
Rv2534cefp0.916
Rv2448cvalS0.916
Rv0120cfusA20.916
Rv2534cefp0.916
Rv2448cvalS0.916
Rv0120cfusA20.916
Rv2534cefp0.916
Rv2448cvalS0.916
Rv0120cfusA20.916
Rv0120cfusA20.916
Rv0722rpmD0.914
Rv0006gyrA0.902
Rv0006gyrA0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
kirromycinPubChem0.974796.943
LABILOMYCINPubChem0.967839.019
GEAPubChem0.9381290.52
guanosine diphosphatePubChem0.933443.201
GE2270 APubChem0.911290.52
magnesiumPubChem0.90824.305
GE2270APubChem0.891290.52
Gpp(NH)pPubChem0.865522.196
inhibits protein synthesisPubChem0.799423.202
polyphenylalaninePubChem0.78165.189
zincPubChem0.75565.409
micrococcinPubChem0.7541144.37
7mgPubChem0.752379.263
C04639PubChem0.752326.197
pseudouridylic acidPubChem0.752324.181
pseudouridine 5'-phosphatePubChem0.752324.181
methyl 4-[3-[3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]-4,6-dimethyl-9-oxoimidazo[1,2-a]purin-PubChem0.752588.462
guaninePubChem0.75151.126
guanosinePubChem0.739283.241
guanosine triphosphatePubChem0.725523.18
UDPGAPubChem0.721580.285
Antibiotic X-5108PubChem0.716810.969
[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl phosphatePubChem0.714338.208
ara-TMPPubChem0.714338.208