Rv0120c

Tuberculist information
Gene namefusA2
Protein functionProbable elongation factor G FusA2 (EF-G)
Functional category(tuberculist)information pathways
Gene location(kb)145.627
Molecular mass(da)75630.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 714
	  		  	1    MADRVNASQGAAAAPTANGPGGVRNVVLVGPSGGGKTTLIEALLVAAKVLSRPGSVTEGT   60
			  	61   TVCDFDEAEIRQQRSVGLAVASLAYDGIKVNLVDTPGYADFVGELRAGLRAADCALFVIA  120
			  	121  ANEGVDEPTKSLWQECSQVGMPRAVVITKLDHARANYREALTAAQDAFGDKVLPLYLPSG  180
			  	181  DGLIGLLSQALYEYADGKRTTRTPAESDTERIEEARGALIEGIIEESEDESLMERYLGGE  240
			  	241  TIDESVLIQDLEKAVARGSFFPVIPVCSSTGVGTLELLEVATRGFPSPMEHPLPEVFTPQ  300
			  	301  GVPHAELACDNDAPLLAEVVKTTSDPYVGRVSLVRVFSGTIRPDTTVHVSGHFSSFFGGG  360
			  	361  TSNTHPDHDEDERIGVLSFPLGKQQRPAAAVVAGDICAIGKLSRAETGDTLSDKAEPLVL  420
			  	421  KPWTMPEPLLPIAIAAHAKTDEDKLSVGLGRLAAEDPTLRIEQNQETHQVVLWCMGEAHA  480
			  	481  GVVLDTLANRYGVSVDTIELRVPLRETFAGNAKGHGRHIKQSGGHGQYGVCDIEVEPLPE  540
			  	541  GSGFEFLDKVVGGAVPRQFIPNVEKGVRAQMDKGVHAGYPVVDIRVTLLDGKAHSVDSSD  600
			  	601  FAFQMAGALALREAAAATKVILLEPIDEISVLVPDDFVGAVLGDLSSRRGRVLGTETAGH  660
			  	661  DRTVIKAEVPQVELTRYAIDLRSLAHGAASFTRSFARYEPMPESAAARVKAGAG

Known structures in the PDB
No Known structures
1 72 143 214 285 356 427 498 569 640 711 Range: 22 to 287  |  Coverage: 37% GTP_EFTU Range: 329 to 412  |  Coverage: 11% GTP_EFTU_D2 Range: 425 to 499  |  Coverage: 10% EFG_II Range: 500 to 619  |  Coverage: 16% EFG_IV Range: 621 to 709  |  Coverage: 12% EFG_C Range: 23 to 709  |  Coverage: 96% 1 Range: 20 to 714  |  Coverage: 97% 1 Range: 425 to 503  |  Coverage: 10% 2 Range: 617 to 710  |  Coverage: 13% 3 Range: 500 to 619  |  Coverage: 16% 4 Range: 22 to 287  |  Coverage: 37% 5
Number of amino acids : 714
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GTP_EFTUPF0000922-287
GTP_EFTU_D2PF03144329-412
EFG_IIPF14492425-499
EFG_IVPF03764500-619
EFG_CPF00679621-709
Mtb Structural Proteome models
Model Number1
Model nameRv0120c
Template1WDT    APDBCREDO
Template coverage9_657
Template Identity(%)38.2
Model coverage(%)96.1
Normalized DOPE score-0.166

Structure Models from Chopin
Model Number1
Profileb.43.3.1, c.37.1.8, d.14.1.1, d.58.11.1 - 2.40.30.10, 3.30.70.870, 3.40.50.300
Click for model details
zscore95.15
Residue begin20
Residue end714
Model Number2
Profile3.30.70.870
Click for model details
zscore22.71
Residue begin425
Residue end503
Model Number3
Profile3.30.70.240
Click for model details
zscore19.55
Residue begin617
Residue end710
Model Number4
Profiled.14.1.1 - 3.30.230.10
Click for model details
zscore13.21
Residue begin500
Residue end619
Model Number5
Profilec.37.1.8 - 3.40.50.300
Click for model details
zscore4.93
Residue begin22
Residue end287
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0120cGene nameConfidence Score
Rv0704rplB0.983
Rv0704rplB0.983
Rv0683rpsG0.98
Rv0701rplC0.979
Rv0719rplF0.975
Rv0714rplN0.967
Rv0700rpsJ0.965
Rv0682rpsL0.963
Rv2889ctsf0.951
Rv2889ctsf0.951
Rv0708rplP0.95
Rv0667rpoB0.949
Rv0716rplE0.949
Rv0667rpoB0.949
Rv0667rpoB0.949
Rv0667rpoB0.949
Rv0667rpoB0.949
Rv0667rpoB0.949
Rv0716rplE0.949
Rv0702rplD0.947
Rv3457crpoA0.946
Rv3457crpoA0.946
Rv3457crpoA0.946
Rv0668rpoC0.942
Rv0668rpoC0.942
Rv0641rplA0.942
Rv0668rpoC0.942
Rv0668rpoC0.942
Rv0668rpoC0.942
Rv0718rpsH0.939
Rv3459crpsK0.935
Rv0705rpsS0.935
Rv0707rpsC0.932
Rv0707rpsC0.932
Rv0721rpsE0.929
Rv0721rpsE0.929
Rv0640rplK0.917
Rv0640rplK0.917
Rv1641infC0.916
Rv0685tuf0.916
Rv0685tuf0.916
Rv1641infC0.916
Rv0685tuf0.916
Rv0703rplW0.909
Rv3460crpsM0.905
Rv1643rplT0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB02703DrugBankFusidic Acid
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions