Rv0701

Tuberculist information
Gene namerplC
Protein function50S ribosomal protein L3 RplC
Functional category(tuberculist)information pathways
Gene location(kb)800.809
Molecular mass(da)23090.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 217
	  		  	1    MARKGILGTKLGMTQVFDESNRVVPVTVVKAGPNVVTRIRTPERDGYSAVQLAYGEISPR   60
			  	61   KVNKPLTGQYTAAGVNPRRYLAELRLDDSDAATEYQVGQELTAEIFADGSYVDVTGTSKG  120
			  	121  KGFAGTMKRHGFRGQGASHGAQAVHRRPGSIGGCATPARVFKGTRMAGRMGNDRVTVLNL  180
			  	181  LVHKVDAENGVLLIKGAVPGRTGGLVMVRSAIKRGEK

Known structures in the PDB
No Known structures
1 22 43 64 85 106 127 148 169 190 211 Range: 10 to 209  |  Coverage: 91% Ribosomal_L3 Range: 4 to 213  |  Coverage: 96% 1 Range: 3 to 215  |  Coverage: 97% 1
Number of amino acids : 217
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribosomal_L3PF0029710-209
Mtb Structural Proteome models
Model Number1
Model nameRv0701
Template1NKW    BPDBCREDO
Template coverage2_203
Template Identity(%)54.5
Model coverage(%)96.3
Normalized DOPE score1.748

Structure Models from Chopin
Model Number1
Profileb.43.3.2
Click for model details
zscore41.05
Residue begin3
Residue end215
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0701Gene nameConfidence Score
Rv0702rplD0.999
Rv0716rplE0.999
Rv0641rplA0.999
Rv0707rpsC0.999
Rv0703rplW0.999
Rv0716rplE0.999
Rv0708rplP0.999
Rv0704rplB0.999
Rv0704rplB0.999
Rv0719rplF0.999
Rv0714rplN0.999
Rv0640rplK0.999
Rv0706rplV0.999
Rv0640rplK0.999
Rv0707rpsC0.999
Rv0721rpsE0.998
Rv3456crplQ0.998
Rv0721rpsE0.998
Rv3460crpsM0.998
Rv0652rplL0.998
Rv0709rpmC0.998
Rv0723rplO0.998
Rv3443crplM0.998
Rv0720rplR0.998
Rv0700rpsJ0.998
Rv0715rplX0.998
Rv3459crpsK0.997
Rv0684fusA10.997
Rv0684fusA10.997
Rv0651rplJ0.997
Rv0684fusA10.997
Rv0705rpsS0.997
Rv0684fusA10.997
Rv0684fusA10.997
Rv0710rpsQ0.996
Rv3458crpsD0.996
Rv3458crpsD0.996
Rv3457crpoA0.995
Rv3457crpoA0.995
Rv3457crpoA0.995
Rv3442crpsI0.995
Rv2890crpsB0.995
Rv2441crpmA0.995
Rv0668rpoC0.994
Rv0668rpoC0.994
Rv0722rpmD0.994
Rv0683rpsG0.994
Rv0668rpoC0.994
Rv0668rpoC0.994
Rv0668rpoC0.994
Rv1643rplT0.993
Rv2904crplS0.993
Rv0718rpsH0.992
Rv2442crplU0.991
Rv0667rpoB0.991
Rv0667rpoB0.991
Rv0056rplI0.991
Rv0667rpoB0.991
Rv0056rplI0.991
Rv0667rpoB0.991
Rv0667rpoB0.991
Rv0667rpoB0.991
Rv0682rpsL0.99
Rv0732secY0.99
Rv0717rpsN10.989
Rv2889ctsf0.989
Rv2889ctsf0.989
Rv2056crpsN20.988
Rv0685tuf0.987
Rv0685tuf0.987
Rv0685tuf0.987
Rv0639nusG0.983
Rv0639nusG0.983
Rv0120cfusA20.979
Rv0120cfusA20.979
Rv0120cfusA20.979
Rv0120cfusA20.979
Rv0120cfusA20.979
Rv2057crpmG10.978
Rv0733adk0.978
Rv0734mapA0.975
Rv3461crpmJ0.971
Rv2882cfrr0.97
Rv2861cmapB0.969
Rv0634BrpmG20.969
Rv1298rpmE0.969
Rv2785crpsO0.961
Rv1015crplY0.958
Rv1015crplY0.958
Rv1630rpsA0.952
Rv2462ctig0.949
Rv2462ctig0.949
Rv1017cprsA0.949
Rv2462ctig0.949
Rv1017cprsA0.949
Rv0053rpsF0.949
Rv2906ctrmD0.948
Rv2839cinfB0.946
Rv2839cinfB0.946
Rv2839cinfB0.946
Rv2839cinfB0.946
Rv1641infC0.94
Rv1641infC0.94
Rv3924crpmH0.939
Rv1297rho0.935
Rv1297rho0.935
Rv1297rho0.935
Rv3462cinfA0.934
Rv1308atpA0.934
Rv1308atpA0.934
Rv1308atpA0.934
Rv0055rpsR10.933
Rv2058crpmB20.931
Rv3455ctruA0.925
Rv2783cgpsI0.923
Rv2783cgpsI0.923
Rv2783cgpsI0.923
Rv2783cgpsI0.923
Rv2783cgpsI0.923
Rv1699pyrG0.922
Rv1699pyrG0.922
Rv1023eno0.917
Rv1023eno0.917
Rv2909crpsP0.911
Rv1649pheS0.911
Rv1649pheS0.911
Rv2992cgltS0.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB01256DrugBankRetapamulin
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
zincPubChem0.85565.409
magnesiumPubChem0.79824.305
(1R,2R,4R,6R,7R,8R,10S,13R,14S)-7-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-1PubChem0.706812.004
telithromycinPubChem0.706812.004
bryamycinPubChem0.7031664.89
nchembio.341-comp1PubChem0.7031664.89