SInCRe - Rv2861c

Tuberculist information

Gene name	mapB
Protein function	Methionine aminopeptidase MapB (map) (peptidase M)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	3173.16
Molecular mass(da)	30891
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 285

	  		  	1    MPSRTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGA   60
			  	61   LAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDST  120
			  	121  VITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRAL  180
			  	181  SVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPM  240
			  	241  INLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTCL

Known structures in the PDB

	PDB ID	1Y1N
	Total residue count	291
	Number of chains	1
	Method	X-RAY
	Resolution	1.51

	PDB ID	1YJ3
	Total residue count	291
	Number of chains	1
	Method	X-RAY
	Resolution	1.6

	PDB ID	3IU7
	Total residue count	288
	Number of chains	1
	Method	X-RAY
	Resolution	1.4

	PDB ID	3IU8
	Total residue count	288
	Number of chains	1
	Method	X-RAY
	Resolution	1.85

	PDB ID	3IU9
	Total residue count	288
	Number of chains	1
	Method	X-RAY
	Resolution	1.75

	PDB ID	3PKA
	Total residue count	285
	Number of chains	1
	Method	X-RAY
	Resolution	1.25

	PDB ID	3PKB
	Total residue count	285
	Number of chains	1
	Method	X-RAY
	Resolution	1.25

	PDB ID	3PKC
	Total residue count	285
	Number of chains	1
	Method	X-RAY
	Resolution	1.47

	PDB ID	3PKD
	Total residue count	285
	Number of chains	1
	Method	X-RAY
	Resolution	1.47

	PDB ID	3PKE
	Total residue count	285
	Number of chains	1
	Method	X-RAY
	Resolution	1.6

	PDB ID	3ROR
	Total residue count	291
	Number of chains	1
	Method	X-RAY
	Resolution	2

	PDB ID	4IDY
	Total residue count	291
	Number of chains	1
	Method	X-RAY
	Resolution	2

	PDB ID	4IEC
	Total residue count	291
	Number of chains	1
	Method	X-RAY
	Resolution	2

	PDB ID	4IF7
	Total residue count	291
	Number of chains	1
	Method	X-RAY
	Resolution	2

Number of amino acids : 285

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Peptidase_M24	PF00557	48-276

Mtb Structural Proteome models

Model Number	1
Model name	Rv2861c_3iu7_A
Template	3IU7 APDB CREDO
Template coverage	2_285
Template Identity(%)	100.0
Model coverage(%)	99.3
Normalized DOPE score	-2.055

Model Number	2
Model name	Rv2861c
Template	1Y1N APDB CREDO
Template coverage	4_285
Template Identity(%)	100.0
Model coverage(%)	98.6
Normalized DOPE score	-1.735

Structure Models from Chopin

Model Number	1
Profile	d.127.1.1 - 3.90.230.10 Click for model details
zscore	38.61
Residue begin	1
Residue end	285

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv2861c	Gene name	Confidence Score
Rv0732	secY	0.988
Rv0733	adk	0.986
Rv0716	rplE	0.982
Rv0716	rplE	0.982
Rv0714	rplN	0.979
Rv3459c	rpsK	0.979
Rv3456c	rplQ	0.979
Rv0708	rplP	0.977
Rv0720	rplR	0.976
Rv0721	rpsE	0.975
Rv0721	rpsE	0.975
Rv0723	rplO	0.971
Rv0700	rpsJ	0.97
Rv0701	rplC	0.969
Rv0710	rpsQ	0.969
Rv0719	rplF	0.968
Rv0715	rplX	0.968
Rv0702	rplD	0.968
Rv3457c	rpoA	0.967
Rv3457c	rpoA	0.967
Rv3457c	rpoA	0.967
Rv0703	rplW	0.966
Rv0718	rpsH	0.966
Rv3460c	rpsM	0.964
Rv0704	rplB	0.963
Rv0704	rplB	0.963
Rv0705	rpsS	0.963
Rv0707	rpsC	0.96
Rv0707	rpsC	0.96
Rv0706	rplV	0.955
Rv0717	rpsN1	0.952
Rv3458c	rpsD	0.949
Rv3458c	rpsD	0.949
Rv0684	fusA1	0.917
Rv0684	fusA1	0.917
Rv0684	fusA1	0.917
Rv0684	fusA1	0.917
Rv0684	fusA1	0.917
Rv2889c	tsf	0.914
Rv2889c	tsf	0.914
Rv3462c	infA	0.914
Rv0709	rpmC	0.909

Potential ligand/drug binding sites

Protein Model	Pocket Number	Drug Binding Site	PMIN Score	Pvalue PMIN	PMAX Score	Pvalue PMAX
Rv2861c_3iu7_A	2	2xpv_MIY_A_1209 PDB CREDO	0.619	0.157	0.558	0.004
Rv2861c_3iu7_A	2	3tkd_CYZ_A_266 PDB CREDO	0.629	0.146	0.552	0.005
Rv2861c_3iu7_A	2	1cil_ETS_A_263 PDB CREDO	0.569	0.218	0.550	0.005
Rv2861c_3iu7_A	2	1hwi_115_A_2 PDB CREDO	0.567	0.220	0.549	0.005
Rv2861c_3iu7_A	2	1lhv_NOG_A_301 PDB CREDO	0.602	0.177	0.545	0.005
Rv2861c_3iu7_A	2	3tne_RIT_A_401 PDB CREDO	0.620	0.155	0.545	0.005
Rv2861c_3iu7_A	2	3jwq_VIA_D_901 PDB CREDO	0.558	0.233	0.540	0.006
Rv2861c_3iu7_A	2	3tne_RIT_B_401 PDB CREDO	0.607	0.170	0.533	0.007
Rv2861c_3iu7_A	2	2a69_RPT_M_8002 PDB CREDO	0.533	0.269	0.533	0.007
Rv2861c_3iu7_A	2	2h79_T3_A_1 PDB CREDO	0.547	0.248	0.530	0.007
Rv2861c_3iu7_A	2	3bbt_FMM_D_91 PDB CREDO	0.548	0.247	0.529	0.007
Rv2861c_3iu7_A	2	1oq5_CEL_A_701 PDB CREDO	0.608	0.170	0.529	0.007
Rv2861c_3iu7_A	2	3n58_ADN_A_500 PDB CREDO	0.586	0.196	0.529	0.007
Rv2861c_3iu7_A	2	3tkd_CYZ_B_267 PDB CREDO	0.638	0.136	0.527	0.007
Rv2861c_3iu7_A	2	2h77_T3_A_1 PDB CREDO	0.527	0.278	0.527	0.007
Rv2861c_3iu7_A	2	3k2h_LYA_B_514 PDB CREDO	0.581	0.203	0.524	0.008
Rv2861c_3iu7_A	2	4eyb_0WO_A_303 PDB CREDO	0.581	0.203	0.524	0.008
Rv2861c_3iu7_A	2	1hwi_115_C_4 PDB CREDO	0.559	0.232	0.522	0.008
Rv2861c_3iu7_A	2	1uwh_BAX_B_1723 PDB CREDO	0.632	0.143	0.522	0.008
Rv2861c_3iu7_A	2	1uwh_BAX_A_1723 PDB CREDO	0.632	0.143	0.521	0.008
Rv2861c_3iu7_A	2	1lhu_EST_A_301 PDB CREDO	0.578	0.207	0.521	0.008
Rv2861c_3iu7_A	2	3oct_1N1_A_663 PDB CREDO	0.558	0.233	0.521	0.008
Rv2861c_3iu7_A	2	2aa5_STR_A_301 PDB CREDO	0.538	0.260	0.521	0.008
Rv2861c_3iu7_A	2	4eb6_VLB_C_503 PDB CREDO	0.596	0.184	0.519	0.008
Rv2861c_3iu7_A	2	1zgy_BRL_A_503 PDB CREDO	0.518	0.290	0.518	0.008
Rv2861c_3iu7_A	2	1hwi_115_B_1 PDB CREDO	0.590	0.191	0.518	0.008
Rv2861c_3iu7_A	2	3frq_ERY_B_195 PDB CREDO	0.589	0.192	0.517	0.008
Rv2861c_3iu7_A	2	1hwi_115_D_3 PDB CREDO	0.588	0.193	0.516	0.009
Rv2861c_3iu7_A	2	2aa5_STR_B_302 PDB CREDO	0.533	0.268	0.516	0.009
Rv2861c_3iu7_A	2	3jwq_VIA_B_901 PDB CREDO	0.592	0.188	0.515	0.009
Rv2861c_3iu7_A	2	3ln1_CEL_D_682 PDB CREDO	0.532	0.269	0.515	0.009
Rv2861c_3iu7_A	2	1hwk_117_D_3 PDB CREDO	0.621	0.155	0.512	0.009
Rv2861c_3iu7_A	2	2aa6_STR_A_401 PDB CREDO	0.529	0.274	0.512	0.009
Rv2861c_3iu7_A	2	1p93_DEX_B_2999 PDB CREDO	0.530	0.273	0.512	0.009
Rv2861c_3iu7_A	2	2aa6_STR_B_402 PDB CREDO	0.529	0.274	0.511	0.009
Rv2861c_3iu7_A	2	2h42_VIA_A_901 PDB CREDO	0.527	0.277	0.510	0.009
Rv2861c_3iu7_A	2	1jg2_ADN_A_500 PDB CREDO	0.545	0.251	0.509	0.009
Rv2861c_3iu7_A	2	1uob_PNN_A_1311 PDB CREDO	0.636	0.139	0.509	0.010
Rv2861c_3iu7_A	2	3ut5_LOC_D_502 PDB CREDO	0.579	0.206	0.508	0.010
Rv2861c_3iu7_A	2	1z2b_VLB_C_800 PDB CREDO	0.634	0.140	0.508	0.010
Rv2861c_3iu7_A	2	1p93_DEX_A_1999 PDB CREDO	0.525	0.279	0.508	0.010
Rv2861c_3iu7_A	2	4e3a_ADN_B_500 PDB CREDO	0.628	0.147	0.508	0.010
Rv2861c_3iu7_A	2	2aax_PDN_B_503 PDB CREDO	0.525	0.280	0.508	0.010
Rv2861c_3iu7_A	2	1fr6_AZR_B_362 PDB CREDO	0.652	0.123	0.507	0.010
Rv2861c_3iu7_A	2	3spk_TPV_A_100 PDB CREDO	0.506	0.309	0.506	0.010
Rv2861c_3iu7_A	2	3gws_T3_X_500 PDB CREDO	0.541	0.257	0.506	0.010
Rv2861c_3iu7_A	2	2aax_PDN_A_502 PDB CREDO	0.523	0.283	0.506	0.010
Rv2861c_3iu7_A	2	1ya3_STR_B_2001 PDB CREDO	0.541	0.256	0.506	0.010
Rv2861c_3iu7_A	2	1fr6_AZR_A_362 PDB CREDO	0.649	0.126	0.505	0.010
Rv2861c_3iu7_A	2	3mne_DEX_A_784 PDB CREDO	0.538	0.260	0.504	0.010
Rv2861c_3iu7_A	2	1uwj_BAX_A_1723 PDB CREDO	0.707	0.075	0.504	0.010
Rv2861c_3iu7_A	2	3fuu_ADN_A_0 PDB CREDO	0.670	0.106	0.502	0.011
Rv2861c_3iu7_A	2	3gn8_DEX_B_247 PDB CREDO	0.536	0.265	0.501	0.011
Rv2861c_3iu7_A	2	1ya3_STR_A_1001 PDB CREDO	0.537	0.263	0.501	0.011
Rv2861c_3iu7_A	2	2a69_RPT_C_8001 PDB CREDO	0.620	0.156	0.501	0.011
Rv2861c_3iu7_A	2	3f4x_KLT_A_300 PDB CREDO	0.644	0.131	0.501	0.011
Rv2861c_3iu7_A	2	3d91_REM_A_350 PDB CREDO	0.644	0.130	0.500	0.011
Rv2861c_3iu7_A	2	1m2z_DEX_D_401 PDB CREDO	0.534	0.266	0.500	0.011

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
cobaltPubChem	0.991	117.866
1xnzPubChem	0.988	222.624
manganesePubChem	0.976	54.938
L-methioninePubChem	0.969	149.211
chloridePubChem	0.956	35.453
nickelPubChem	0.933	58.6934
potassiumPubChem	0.929	39.0983
potassium hydridePubChem	0.929	40.1062
2-mercaptoethanolPubChem	0.91	78.1334
sulfatePubChem	0.9	96.0626
hydron sulfatePubChem	0.9	196.157
STK387218PubChem	0.9	275.158
Aids225010PubChem	0.9	209.243
fumagillinPubChem	0.722	458.544