Rv0718

Tuberculist information
Gene namerpsH
Protein function30S ribosomal protein S8 RpsH
Functional category(tuberculist)information pathways
Gene location(kb)812.976
Molecular mass(da)14411.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 132
	  		  	1    MTMTDPIADFLTRLRNANSAYHDEVSLPHSKLKANIAQILKNEGYISDFRTEDARVGKSL   60
			  	61   VIQLKYGPSRERSIAGLRRVSKPGLRVYAKSTNLPRVLGGLGVAIISTSSGLLTDRQAAR  120
			  	121  QGVGGEVLAYVW

Known structures in the PDB
No Known structures
1 14 27 40 53 66 79 92 105 118 131 Range: 5 to 132  |  Coverage: 96% Ribosomal_S8 Range: 3 to 131  |  Coverage: 96% 1 Range: 1 to 132  |  Coverage: 99% 1 Range: 1 to 81  |  Coverage: 60% 2 Range: 75 to 132  |  Coverage: 43% 3
Number of amino acids : 132
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribosomal_S8PF004105-132
Mtb Structural Proteome models
Model Number1
Model nameRv0718
Template1SEI    APDBCREDO
Template coverage2_129
Template Identity(%)59.4
Model coverage(%)97.0
Normalized DOPE score-1.134

Structure Models from Chopin
Model Number1
Profiled.140.1.1
Click for model details
zscore28.3
Residue begin1
Residue end132
Model Number2
Profile3.30.1370.30
Click for model details
zscore16.52
Residue begin1
Residue end81
Model Number3
Profile3.30.1490.10
Click for model details
zscore12.88
Residue begin75
Residue end132
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0718Gene nameConfidence Score
Rv0721rpsE0.999
Rv3458crpsD0.999
Rv3459crpsK0.999
Rv0719rplF0.999
Rv0710rpsQ0.999
Rv0720rplR0.999
Rv0721rpsE0.999
Rv3458crpsD0.999
Rv0716rplE0.998
Rv0707rpsC0.998
Rv0682rpsL0.998
Rv0716rplE0.998
Rv0683rpsG0.998
Rv0723rplO0.998
Rv3460crpsM0.998
Rv0717rpsN10.998
Rv0705rpsS0.998
Rv0700rpsJ0.998
Rv3442crpsI0.998
Rv0707rpsC0.998
Rv0714rplN0.997
Rv0702rplD0.996
Rv0651rplJ0.996
Rv0722rpmD0.996
Rv0703rplW0.996
Rv0715rplX0.996
Rv0685tuf0.995
Rv0708rplP0.995
Rv0704rplB0.995
Rv0685tuf0.995
Rv0704rplB0.995
Rv0685tuf0.995
Rv0641rplA0.995
Rv2056crpsN20.994
Rv0709rpmC0.994
Rv0684fusA10.993
Rv3456crplQ0.993
Rv0639nusG0.993
Rv0684fusA10.993
Rv0639nusG0.993
Rv0684fusA10.993
Rv0684fusA10.993
Rv0706rplV0.993
Rv0684fusA10.993
Rv3443crplM0.993
Rv0640rplK0.992
Rv0640rplK0.992
Rv0701rplC0.992
Rv3457crpoA0.99
Rv0732secY0.99
Rv3457crpoA0.99
Rv3457crpoA0.99
Rv0652rplL0.989
Rv2785crpsO0.989
Rv0053rpsF0.989
Rv3462cinfA0.988
Rv0667rpoB0.986
Rv0667rpoB0.986
Rv0667rpoB0.986
Rv0667rpoB0.986
Rv0667rpoB0.986
Rv0667rpoB0.986
Rv2442crplU0.983
Rv1641infC0.982
Rv1641infC0.982
Rv2890crpsB0.98
Rv0668rpoC0.977
Rv0668rpoC0.977
Rv0668rpoC0.977
Rv0668rpoC0.977
Rv0668rpoC0.977
Rv0734mapA0.976
Rv2412rpsT0.974
Rv2889ctsf0.967
Rv2889ctsf0.967
Rv2861cmapB0.966
Rv2839cinfB0.964
Rv2839cinfB0.964
Rv2839cinfB0.964
Rv2839cinfB0.964
Rv2909crpsP0.963
Rv0055rpsR10.96
Rv2882cfrr0.958
Rv0733adk0.957
Rv2441crpmA0.955
Rv0056rplI0.942
Rv0056rplI0.942
Rv2904crplS0.94
Rv0120cfusA20.939
Rv0120cfusA20.939
Rv0120cfusA20.939
Rv0120cfusA20.939
Rv0120cfusA20.939
Rv2906ctrmD0.938
Rv1643rplT0.936
Rv2534cefp0.93
Rv2534cefp0.93
Rv2534cefp0.93
Rv1308atpA0.923
Rv1308atpA0.923
Rv1308atpA0.923
Rv2793ctruB0.923
Rv2793ctruB0.923
Rv3455ctruA0.919
Rv2057crpmG10.917
Rv1023eno0.909
Rv1023eno0.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00759DrugBankTetracycline
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
spectinomycinPubChem0.859332.35
guanosine diphosphatePubChem0.788443.201
zincPubChem0.78865.409
magnesiumPubChem0.78824.305
CSIPubChem0.703172.185
kasugamycinPubChem0.703379.363
2,3-diaminopropionic acidPubChem0.703104.108
phenylalaninalPubChem0.703149.19
MYC-8003PubChem0.703796.943
7mgPubChem0.703379.263
UD29PubChem0.703340.247
kirromycinPubChem0.703796.943
[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl phosphatePubChem0.703338.208
2'-O-methylguanosine 5'-monophosphatePubChem0.703377.247
potassiumPubChem0.70339.0983
L-2,3-diaminopropionic acidPubChem0.703104.108
[5-(2-dimethylamino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic AcidPubChem0.703391.274
streptomycinPubChem0.703581.574
3'-phosphoadenosine 5'-phosphatePubChem0.703427.201
poly(2'-O-methylcytidylic acid)PubChem0.703337.223
pseudouridylic acidPubChem0.703324.181
L-beta-lysinePubChem0.703146.188
DB08185PubChem0.703463.446
poly CPubChem0.703323.197
3'-amino-3'-deoxy AMPPubChem0.703346.236
2-mercaptoethanolPubChem0.70378.1334
CHEBI:603702PubChem0.703558.623
poly(2'-O-methyladenylic acid)PubChem0.703361.248
beta-lysinePubChem0.703146.188
methyl 4-[3-[3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]-4,6-dimethyl-9-oxoimidazo[1,2-a]purin-PubChem0.703588.462
fusidic acidPubChem0.703516.709
[(2R,3S,4R,5R)-5-[2-(dimethylamino)-6-oxo-3H-purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen PubChem0.703391.274
ara-TMPPubChem0.703338.208
guanylatePubChem0.703363.221
potassium hydridePubChem0.70340.1062
[3,4-dihydroxy-5-(2-methylamino-6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.703377.247
guanylyl-(alpha,beta)-methylene-diphosphonatePubChem0.703521.208
C07026PubChem0.703346.236
5-methylcytidylic acidPubChem0.703337.223
adenosine 3',5'-diphosphatePubChem0.703427.201
[3,4-dihydroxy-5-(6-imino-1-methyl-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.703361.248
pactamycinPubChem0.703558.623
adenosine monophosphatePubChem0.703347.221
C04639PubChem0.703326.197
polyuridylic acidPubChem0.703324.181
pseudouridine 5'-phosphatePubChem0.703324.181