Rv0652

Tuberculist information
Gene namerplL
Protein function50S ribosomal protein L7/L12 RplL (SA1)
Functional category(tuberculist)information pathways
Gene location(kb)748.849
Molecular mass(da)13440.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 130
	  		  	1    MAKLSTDELLDAFKEMTLLELSDFVKKFEETFEVTAAAPVAVAAAGAAPAGAAVEAAEEQ   60
			  	61   SEFDVILEAAGDKKIGVIKVVREIVSGLGLKEAKDLVDGAPKPLLEKVAKEAADEAKAKL  120
			  	121  EAAGATVTVK

Known structures in the PDB
No Known structures
1 14 27 40 53 66 79 92 105 118 131 Range: 62 to 130  |  Coverage: 52% Ribosomal_L12 Range: 4 to 130  |  Coverage: 96% 1 Range: 3 to 130  |  Coverage: 97% 1 Range: 62 to 130  |  Coverage: 52% 2 Range: 2 to 39  |  Coverage: 28% 3
Number of amino acids : 130
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribosomal_L12PF0054262-130
Mtb Structural Proteome models
Model Number1
Model nameRv0652
Template1DD3    APDBCREDO
Template coverage1_128
Template Identity(%)54.3
Model coverage(%)96.9
Normalized DOPE score-0.077

Structure Models from Chopin
Model Number1
Profilea.108.1.1, d.45.1.1 - 1.20.5.710, 3.30.1390.10
Click for model details
zscore29.49
Residue begin3
Residue end130
Model Number2
Profiled.45.1.1 - 3.30.1390.10
Click for model details
zscore15.64
Residue begin62
Residue end130
Model Number3
Profilea.108.1.1
Click for model details
zscore7.23
Residue begin2
Residue end39
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0652Gene nameConfidence Score
Rv0640rplK0.999
Rv0640rplK0.999
Rv0641rplA0.999
Rv0651rplJ0.999
Rv0704rplB0.998
Rv0719rplF0.998
Rv0714rplN0.998
Rv0720rplR0.998
Rv0701rplC0.998
Rv0721rpsE0.998
Rv0702rplD0.998
Rv0716rplE0.998
Rv0721rpsE0.998
Rv0716rplE0.998
Rv0708rplP0.998
Rv0704rplB0.998
Rv0723rplO0.997
Rv0668rpoC0.997
Rv3456crplQ0.997
Rv0668rpoC0.997
Rv0668rpoC0.997
Rv0715rplX0.997
Rv0707rpsC0.997
Rv0668rpoC0.997
Rv0707rpsC0.997
Rv0703rplW0.997
Rv0683rpsG0.997
Rv0668rpoC0.997
Rv0706rplV0.996
Rv0056rplI0.996
Rv0056rplI0.996
Rv0667rpoB0.995
Rv0667rpoB0.995
Rv0667rpoB0.995
Rv0667rpoB0.995
Rv0667rpoB0.995
Rv0667rpoB0.995
Rv3443crplM0.993
Rv3459crpsK0.993
Rv0705rpsS0.993
Rv0700rpsJ0.993
Rv3457crpoA0.993
Rv2904crplS0.993
Rv3457crpoA0.993
Rv3457crpoA0.993
Rv0639nusG0.992
Rv0639nusG0.992
Rv3460crpsM0.992
Rv2441crpmA0.991
Rv0710rpsQ0.99
Rv0682rpsL0.99
Rv0718rpsH0.989
Rv0685tuf0.989
Rv2890crpsB0.989
Rv1643rplT0.989
Rv0685tuf0.989
Rv0685tuf0.989
Rv2442crplU0.988
Rv0634BrpmG20.988
Rv0684fusA10.987
Rv0684fusA10.987
Rv0684fusA10.987
Rv0684fusA10.987
Rv0684fusA10.987
Rv3458crpsD0.987
Rv3458crpsD0.987
Rv1015crplY0.983
Rv1015crplY0.983
Rv2889ctsf0.978
Rv0717rpsN10.978
Rv2889ctsf0.978
Rv2057crpmG10.975
Rv2056crpsN20.975
Rv0053rpsF0.974
Rv0722rpmD0.974
Rv0732secY0.968
Rv3442crpsI0.966
Rv2462ctig0.963
Rv2462ctig0.963
Rv2462ctig0.963
Rv0709rpmC0.958
Rv0733adk0.951
Rv1298rpmE0.948
Rv3461crpmJ0.948
Rv3924crpmH0.942
Rv1641infC0.939
Rv1641infC0.939
Rv2839cinfB0.934
Rv2839cinfB0.934
Rv2839cinfB0.934
Rv2839cinfB0.934
Rv0055rpsR10.933
Rv2909crpsP0.928
Rv2906ctrmD0.927
Rv2882cfrr0.921
Rv1023eno0.919
Rv1023eno0.919
Rv1630rpsA0.916
Rv2785crpsO0.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
Coomassie bluePubChem0.834695.584
rifampicinPubChem0.737822.94
hydron sulfatePubChem0.7196.157
sulfatePubChem0.796.0626