Rv0716

Tuberculist information
Gene namerplE
Protein function50S ribosomal protein L5 RplE
Functional category(tuberculist)information pathways
Gene location(kb)812.059
Molecular mass(da)21019.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 187
	  		  	1    MTTAQKVQPRLKERYRSEIRDALRKQFGYGNVMQIPTVTKVVVNMGVGEAARDAKLINGA   60
			  	61   VNDLALITGQKPEVRRARKSIAQFKLREGMPVGVRVTLRGDRMWEFLDRLTSIALPRIRD  120
			  	121  FRGLSPKQFDGVGNYTFGLAEQAVFHEVDVDKIDRVRGMDINVVTSAATDDEGRALLRAL  180
			  	181  GFPFKEN

Known structures in the PDB
No Known structures
1 19 37 55 73 91 109 127 145 163 181 Range: 31 to 87  |  Coverage: 29% Ribosomal_L5 Range: 91 to 185  |  Coverage: 50% Ribosomal_L5_C Range: 8 to 186  |  Coverage: 95% 1 Range: 7 to 187  |  Coverage: 96% 1
Number of amino acids : 187
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribosomal_L5PF0028131-87
Ribosomal_L5_CPF0067391-185
Mtb Structural Proteome models
Model Number1
Model nameRv0716
Template1IQ4    APDBCREDO
Template coverage1_179
Template Identity(%)56.4
Model coverage(%)95.2
Normalized DOPE score-1.298

Structure Models from Chopin
Model Number1
Profiled.77.1.1 - 3.30.1440.10
Click for model details
zscore34.09
Residue begin7
Residue end187
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0716Gene nameConfidence Score
Rv3456crplQ0.999
Rv0704rplB0.999
Rv0719rplF0.999
Rv3460crpsM0.999
Rv0704rplB0.999
Rv0720rplR0.999
Rv0640rplK0.999
Rv0714rplN0.999
Rv0640rplK0.999
Rv0706rplV0.999
Rv0701rplC0.999
Rv0715rplX0.999
Rv0641rplA0.999
Rv0702rplD0.999
Rv0723rplO0.999
Rv0708rplP0.999
Rv0721rpsE0.998
Rv0721rpsE0.998
Rv3443crplM0.998
Rv0717rpsN10.998
Rv0703rplW0.998
Rv0718rpsH0.998
Rv0652rplL0.998
Rv0683rpsG0.997
Rv3457crpoA0.997
Rv3457crpoA0.997
Rv3457crpoA0.997
Rv0707rpsC0.997
Rv0722rpmD0.997
Rv0651rplJ0.997
Rv0707rpsC0.997
Rv3459crpsK0.997
Rv0705rpsS0.996
Rv0700rpsJ0.996
Rv3442crpsI0.996
Rv3458crpsD0.996
Rv3458crpsD0.996
Rv0684fusA10.995
Rv0710rpsQ0.995
Rv0684fusA10.995
Rv0684fusA10.995
Rv0684fusA10.995
Rv0684fusA10.995
Rv0709rpmC0.994
Rv0732secY0.993
Rv0685tuf0.993
Rv0685tuf0.993
Rv0685tuf0.993
Rv2904crplS0.992
Rv2442crplU0.992
Rv0056rplI0.991
Rv2441crpmA0.991
Rv0056rplI0.991
Rv0667rpoB0.99
Rv2890crpsB0.99
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv0667rpoB0.99
Rv0682rpsL0.99
Rv0667rpoB0.99
Rv3462cinfA0.989
Rv2056crpsN20.989
Rv1643rplT0.988
Rv0639nusG0.986
Rv0639nusG0.986
Rv0734mapA0.985
Rv0668rpoC0.984
Rv0668rpoC0.984
Rv0668rpoC0.984
Rv0668rpoC0.984
Rv0668rpoC0.984
Rv2889ctsf0.983
Rv2889ctsf0.983
Rv2861cmapB0.982
Rv2882cfrr0.975
Rv1023eno0.972
Rv1023eno0.972
Rv1298rpmE0.969
Rv1015crplY0.964
Rv1015crplY0.964
Rv0350dnaK0.961
Rv0733adk0.959
Rv3461crpmJ0.956
Rv0053rpsF0.956
Rv0634BrpmG20.954
Rv2916cffh0.953
Rv2916cffh0.953
Rv2916cffh0.953
Rv2839cinfB0.95
Rv2839cinfB0.95
Rv2839cinfB0.95
Rv2839cinfB0.95
Rv0120cfusA20.949
Rv0120cfusA20.949
Rv0120cfusA20.949
Rv0120cfusA20.949
Rv0120cfusA20.949
Rv2906ctrmD0.948
Rv1699pyrG0.946
Rv1699pyrG0.946
Rv2534cefp0.945
Rv2057crpmG10.945
Rv2534cefp0.945
Rv2534cefp0.945
Rv1641infC0.944
Rv1641infC0.944
Rv2783cgpsI0.942
Rv2783cgpsI0.942
Rv2783cgpsI0.942
Rv2783cgpsI0.942
Rv2783cgpsI0.942
Rv3455ctruA0.934
Rv1112Rv11120.931
Rv1112Rv11120.931
Rv1308atpA0.931
Rv1308atpA0.931
Rv1308atpA0.931
Rv2572caspS0.93
Rv2572caspS0.93
Rv2572caspS0.93
Rv2462ctig0.927
Rv2462ctig0.927
Rv2462ctig0.927
Rv1437pgk0.922
Rv2785crpsO0.921
Rv3336ctrpS0.92
Rv2448cvalS0.917
Rv2448cvalS0.917
Rv2448cvalS0.917
Rv0041leuS0.916
Rv0041leuS0.916
Rv0041leuS0.916
Rv2992cgltS0.908
Rv2440cobg0.908
Rv2440cobg0.908
Rv2440cobg0.908
Rv3924crpmH0.908
Rv3834cserS0.905
Rv3834cserS0.905
Rv2909crpsP0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
zincPubChem0.80465.409
magnesiumPubChem0.824.305
SeMetPubChem0.708196.106
selenomethioninePubChem0.708196.106
telithromycinPubChem0.708812.004
(1R,2R,4R,6R,7R,8R,10S,13R,14S)-7-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-1PubChem0.708812.004
bryamycinPubChem0.7061664.89
nchembio.341-comp1PubChem0.7061664.89