Rv2440c

Tuberculist information
Gene nameobg
Protein functionProbable GTP1/Obg-family GTP-binding protein Obg
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2738.25
Molecular mass(da)50429
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 479
	  		  	1    VPRFVDRVVIHTRAGSGGNGCASVHREKFKPLGGPDGGNGGRGGSIVFVVDPQVHTLLDF   60
			  	61   HFRPHLTAASGKHGMGNNRDGAAGADLEVKVPEGTVVLDENGRLLADLVGAGTRFEAAAG  120
			  	121  GRGGLGNAALASRVRKAPGFALLGEKGQSRDLTLELKTVADVGLVGFPSAGKSSLVSAIS  180
			  	181  AAKPKIADYPFTTLVPNLGVVSAGEHAFTVADVPGLIPGASRGRGLGLDFLRHIERCAVL  240
			  	241  VHVVDCATAEPGRDPISDIDALETELACYTPTLQGDAALGDLAARPRAVVLNKIDVPEAR  300
			  	301  ELAEFVRDDIAQRGWPVFCVSTATRENLQPLIFGLSQMISDYNAARPVAVPRRPVIRPIP  360
			  	361  VDDSGFTVEPDGHGGFVVSGARPERWIDQTNFDNDEAVGYLADRLARLGVEEELLRLGAR  420
			  	421  SGCAVTIGEMTFDWEPQTPAGEPVAMSGRGTDPRLDSNKRVGAAERKAARSRRREHGDG

Known structures in the PDB
No Known structures
1 48 95 142 189 236 283 330 377 424 471 Range: 4 to 158  |  Coverage: 32% GTP1_OBG Range: 161 to 293  |  Coverage: 27% MMR_HSR1 Range: 366 to 434  |  Coverage: 14% DUF1967 Range: 4 to 438  |  Coverage: 90% 1 Range: 1 to 438  |  Coverage: 91% 1 Range: 3 to 158  |  Coverage: 32% 2 Range: 366 to 434  |  Coverage: 14% 3
Number of amino acids : 479
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GTP1_OBGPF010184-158
MMR_HSR1PF01926161-293
DUF1967PF09269366-434
Mtb Structural Proteome models
Model Number1
Model nameRv2440c
Template1UDX    APDBCREDO
Template coverage2_416
Template Identity(%)43.3
Model coverage(%)90.6
Normalized DOPE score0.215

Structure Models from Chopin
Model Number1
Profileb.117.1.1, c.37.1.8, d.242.1.1 - 2.70.210.12, 3.40.50.300
Click for model details
zscore63.71
Residue begin1
Residue end438
Model Number2
Profile2.70.210.12
Click for model details
zscore32.26
Residue begin3
Residue end158
Model Number3
Profiled.242.1.1
Click for model details
zscore16.85
Residue begin366
Residue end434
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2440cGene nameConfidence Score
Rv2441crpmA0.993
Rv2439cproB0.987
Rv2439cproB0.987
Rv2442crplU0.983
Rv2404clepA0.976
Rv2404clepA0.976
Rv2404clepA0.976
Rv2404clepA0.976
Rv1713engA0.968
Rv1713engA0.968
Rv3834cserS0.965
Rv3834cserS0.965
Rv3100csmpB0.949
Rv0684fusA10.942
Rv0684fusA10.942
Rv0684fusA10.942
Rv0684fusA10.942
Rv0684fusA10.942
Rv1007cmetS0.939
Rv2839cinfB0.936
Rv2839cinfB0.936
Rv2839cinfB0.936
Rv2839cinfB0.936
Rv1406fmt0.935
Rv1406fmt0.935
Rv2614cthrS0.932
Rv2614cthrS0.932
Rv2614cthrS0.932
Rv2916cffh0.921
Rv2916cffh0.921
Rv2916cffh0.921
Rv3838cpheA0.917
Rv3838cpheA0.917
Rv2727cmiaA0.915
Rv2883cpyrH0.912
Rv0716rplE0.908
Rv0716rplE0.908
Rv1308atpA0.904
Rv1308atpA0.904
Rv1308atpA0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
guanosine tetraphosphatePubChem0.889603.16
guaninePubChem0.781151.126
magnesiumPubChem0.70224.305