SInCRe - Rv2883c

Tuberculist information

Gene name	pyrH
Protein function	Probable uridylate kinase PyrH (UK) (uridine monophosphate kinase) (UMP kinase)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	3192.37
Molecular mass(da)	27429.6
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 261

	  		  	1    MTEPDVAGAPASKPEPASTGAASAAQLSGYSRVLLKLGGEMFGGGQVGLDPDVVAQVARQ   60
			  	61   IADVVRGGVQIAVVIGGGNFFRGAQLQQLGMERTRSDYMGMLGTVMNSLALQDFLEKEGI  120
			  	121  VTRVQTAITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIGADV  180
			  	181  VLMAKAVDGVFAEDPRVNPEAELLTAVSHREVLDRGLRVADATAFSLCMDNGMPILVFNL  240
			  	241  LTDGNIARAVRGEKIGTLVTT

Known structures in the PDB

	PDB ID	3NWY
	Total residue count	1686
	Number of chains	6
	Method	X-RAY
	Resolution	2.54

Number of amino acids : 261

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
AA_kinase	PF00696	31-239

Mtb Structural Proteome models

Model Number	1
Model name	Rv2883c_3nwy_A
Template	3NWY APDB CREDO
Template coverage	27_261
Template Identity(%)	100.0
Model coverage(%)	89.7
Normalized DOPE score	-1.752

Model Number	2
Model name	Rv2883c
Template	1Z9D APDB CREDO
Template coverage	5_240
Template Identity(%)	54.7
Model coverage(%)	89.3
Normalized DOPE score	-1.349

Structure Models from Chopin

Model Number	1
Profile	c.73.1.3 - 3.40.1160.10 Click for model details
zscore	24.45
Residue begin	1
Residue end	261

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv2883c	Gene name	Confidence Score
Rv2889c	tsf	0.997
Rv2889c	tsf	0.997
Rv3309c	upp	0.994
Rv0382c	pyrE	0.993
Rv2882c	frr	0.992
Rv1712	cmk	0.991
Rv2445c	ndkA	0.988
Rv2783c	gpsI	0.987
Rv2783c	gpsI	0.987
Rv2783c	gpsI	0.987
Rv2783c	gpsI	0.987
Rv2783c	gpsI	0.987
Rv1385	pyrF	0.981
Rv1699	pyrG	0.975
Rv1699	pyrG	0.975
Rv1379	pyrR	0.975
Rv2890c	rpsB	0.974
Rv1383	carA	0.959
Rv1383	carA	0.959
Rv1389	gmk	0.955
Rv3457c	rpoA	0.953
Rv3457c	rpoA	0.953
Rv3457c	rpoA	0.953
Rv2839c	infB	0.947
Rv2839c	infB	0.947
Rv2839c	infB	0.947
Rv2839c	infB	0.947
Rv2361c	Rv2361c	0.938
Rv0700	rpsJ	0.938
Rv3443c	rplM	0.937
Rv1023	eno	0.935
Rv1023	eno	0.935
Rv2870c	dxr	0.932
Rv2992c	gltS	0.932
Rv2870c	dxr	0.932
Rv2870c	dxr	0.932
Rv3396c	guaA	0.929
Rv3396c	guaA	0.929
Rv3396c	guaA	0.929
Rv1292	argS	0.926
Rv1292	argS	0.926
Rv1292	argS	0.926
Rv2139	pyrD	0.924
Rv3834c	serS	0.923
Rv3834c	serS	0.923
Rv0639	nusG	0.921
Rv0639	nusG	0.921
Rv0667	rpoB	0.916
Rv0667	rpoB	0.916
Rv0667	rpoB	0.916
Rv0667	rpoB	0.916
Rv0667	rpoB	0.916
Rv0667	rpoB	0.916
Rv1308	atpA	0.914
Rv2793c	truB	0.914
Rv1308	atpA	0.914
Rv2793c	truB	0.914
Rv1308	atpA	0.914
Rv2440c	obg	0.912
Rv2440c	obg	0.912
Rv2440c	obg	0.912
Rv3001c	ilvC	0.911
Rv3001c	ilvC	0.911
Rv2785c	rpsO	0.907
Rv0041	leuS	0.903
Rv0041	leuS	0.903
Rv0041	leuS	0.903
Rv0733	adk	0.903
Rv0640	rplK	0.902
Rv2448c	valS	0.902
Rv0640	rplK	0.902
Rv2448c	valS	0.902
Rv2448c	valS	0.902

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
polyuridylic acidPubChem	0.996	324.181
uridine diphosphatePubChem	0.996	404.161
guanosine triphosphatePubChem	0.978	523.18
uridine triphosphatePubChem	0.975	484.141
adenosine triphosphatePubChem	0.922	507.181
adenosine diphosphatePubChem	0.907	427.201
carbon dioxidePubChem	0.9	44.0095
orotidine 5-phosphatePubChem	0.9	368.191
protiumPubChem	0.9	2.01576
deuteriumPubChem	0.9	2.01588
H(+)PubChem	0.9	2.01588
orotidine 5'-monophosphatePubChem	0.9	368.191
glycerolPubChem	0.807	92.0938
selenomethioninePubChem	0.799	196.106
SeMetPubChem	0.799	196.106
phosphatePubChem	0.769	96.9872
hydron sulfatePubChem	0.768	196.157
sulfatePubChem	0.768	96.0626
formatePubChem	0.727	45.0174
hydron diphosphatePubChem	0.711	391.981