Rv0041

Tuberculist information
Gene nameleuS
Protein functionProbable leucyl-tRNA synthetase LeuS (leucine--tRNA ligase) (LEURS)
Functional category(tuberculist)information pathways
Gene location(kb)43.562
Molecular mass(da)107563
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 969
	  		  	1    VTESPTAGPGGVPRADDADSDVPRYRYTAELAARLERTWQENWARLGTFNVPNPVGSLAP   60
			  	61   PDGAAVPDDKLFVQDMFPYPSGEGLHVGHPLGYIATDVYARYFRMVGRNVLHALGFDAFG  120
			  	121  LPAEQYAVQTGTHPRTRTEANVVNFRRQLGRLGFGHDSRRSFSTTDVDFYRWTQWIFLQI  180
			  	181  YNAWFDTTANKARPISELVAEFESGARCLDGGRDWAKLTAGERADVIDEYRLVYRADSLV  240
			  	241  NWCPGLGTVLANEEVTADGRSDRGNFPVFRKRLRQWMMRITAYADRLLDDLDVLDWPEQV  300
			  	301  KTMQRNWIGRSTGAVALFSARAASDDGFEVDIEVFTTRPDTLFGATYLVLAPEHDLVDEL  360
			  	361  VAASWPAGVNPLWTYGGGTPGEAIAAYRRAIAAKSDLERQESREKTGVFLGSYAINPANG  420
			  	421  EPVPIFIADYVLAGYGTGAIMAVPGHDQRDWDFARAFGLPIVEVIAGGNISESAYTGDGI  480
			  	481  LVNSDYLNGMSVPAAKRAIVDRLESAGRGRARIEFKLRDWLFARQRYWGEPFPIVYDSDG  540
			  	541  RPHALDEAALPVELPDVPDYSPVLFDPDDADSEPSPPLAKATEWVHVDLDLGDGLKPYSR  600
			  	601  DTNVMPQWAGSSWYELRYTDPHNSERFCAKENEAYWMGPRPAEHGPDDPGGVDLYVGGAE  660
			  	661  HAVLHLLYSRFWHKVLYDLGHVSSREPYRRLVNQGYIQAYAYTDARGSYVPAEQVIERGD  720
			  	721  RFVYPGPDGEVEVFQEFGKIGKSLKNSVSPDEICDAYGADTLRVYEMSMGPLEASRPWAT  780
			  	781  KDVVGAYRFLQRVWRLVVDEHTGETRVADGVELDIDTLRALHRTIVGVSEDFAALRNNTA  840
			  	841  TAKLIEYTNHLTKKHRDAVPRAAVEPLVQMLAPLAPHIAEELWLRLGNTTSLAHGPFPKA  900
			  	901  DAAYLVDETVEYPVQVNGKVRGRVVVAADTDEETLKAAVLTDEKVQAFLAGATPRKVIVV  960
			  	961  AGRLVNLVI

Known structures in the PDB
No Known structures
1 97 193 289 385 481 577 673 769 865 961 Range: 71 to 207  |  Coverage: 14% tRNA-synt_1g Range: 305 to 504  |  Coverage: 20% tRNA-synt_1_2 Range: 814 to 937  |  Coverage: 12% Anticodon_1 Range: 20 to 969  |  Coverage: 97% 1 Range: 305 to 504  |  Coverage: 20% 1 Range: 1 to 119  |  Coverage: 12% 2 Range: 814 to 937  |  Coverage: 12% 3
Number of amino acids : 969
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
tRNA-synt_1gPF0933471-207
tRNA-synt_1_2PF13603305-504
Anticodon_1PF08264814-937
Mtb Structural Proteome models
Model Number1
Model nameRv0041
Template1GAX    APDBCREDO
Template coverage1_780
Template Identity(%)20.3
Model coverage(%)97.9
Normalized DOPE score1.577

Structure Models from Chopin
Model Number1
Profileb.51.1.1
Click for model details
zscore23.79
Residue begin305
Residue end504
Model Number2
Profilea.27.1.1, b.51.1.1 - 1.10.730.10, 2.30.210.10, 3.40.50.620, 3.90.740.10
Click for model details
zscore21.73
Residue begin1
Residue end119
Model Number3
Profilea.27.1.1
Click for model details
zscore6.34
Residue begin814
Residue end937
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0041Gene nameConfidence Score
Rv2839cinfB0.978
Rv2839cinfB0.978
Rv2839cinfB0.978
Rv2839cinfB0.978
Rv2210cilvE0.972
Rv3336ctrpS0.971
Rv2555calaS0.969
Rv2555calaS0.969
Rv2555calaS0.969
Rv1689tyrS0.966
Rv3834cserS0.966
Rv3834cserS0.966
Rv1689tyrS0.966
Rv0056rplI0.965
Rv0056rplI0.965
Rv2783cgpsI0.941
Rv2783cgpsI0.941
Rv2783cgpsI0.941
Rv2783cgpsI0.941
Rv2783cgpsI0.941
Rv2580chisS0.94
Rv2580chisS0.94
Rv0684fusA10.938
Rv0684fusA10.938
Rv0684fusA10.938
Rv0684fusA10.938
Rv0684fusA10.938
Rv2572caspS0.935
Rv2572caspS0.935
Rv2572caspS0.935
Rv2404clepA0.933
Rv2404clepA0.933
Rv2404clepA0.933
Rv2404clepA0.933
Rv1649pheS0.93
Rv1649pheS0.93
Rv3457crpoA0.929
Rv3457crpoA0.929
Rv3457crpoA0.929
Rv3580ccysS10.924
Rv3580ccysS10.924
Rv2882cfrr0.923
Rv0716rplE0.916
Rv0716rplE0.916
Rv2889ctsf0.915
Rv2992cgltS0.915
Rv2889ctsf0.915
Rv0667rpoB0.912
Rv0667rpoB0.912
Rv0667rpoB0.912
Rv0667rpoB0.912
Rv0667rpoB0.912
Rv2785crpsO0.912
Rv0667rpoB0.912
Rv1292argS0.91
Rv1292argS0.91
Rv1292argS0.91
Rv0639nusG0.907
Rv0639nusG0.907
Rv1112Rv11120.905
Rv1112Rv11120.905
Rv2150cftsZ0.904
Rv2150cftsZ0.904
Rv2614cthrS0.903
Rv2614cthrS0.903
Rv2883cpyrH0.903
Rv2614cthrS0.903
Rv0070cglyA20.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
L-leucinePubChem0.976131.173
adenosine monophosphatePubChem0.909347.221
adenosine triphosphatePubChem0.9507.181
pyrophosphatePubChem0.9177.975
norvalinePubChem0.793117.146
zincPubChem0.75165.409
sulfatePubChem0.796.0626