Rv1292

Tuberculist information
Gene nameargS
Protein functionProbable arginyl-tRNA synthetase ArgS (ARGRS) (arginine--tRNA ligase)
Functional category(tuberculist)information pathways
Gene location(kb)1446.38
Molecular mass(da)59677.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 550
	  		  	1    VTPADLAELLKATAAAVLAERGLDASALPQMVTVERPRIPEHGDYASNLAMQLAKKVGTN   60
			  	61   PRELAGWLAEALTKVDGIASAEVAGPGFINMRLETAAQAKVVTSVIDAGHSYGHSLLLAG  120
			  	121  RKVNLEFVSANPTGPIHIGGTRWAAVGDALGRLLTTQGADVVREYYFNDHGAQIDRFANS  180
			  	181  LIAAAKGEPTPQDGYAGSYITNIAEQVLQKAPDALSLPDAELRETFRAIGVDLMFDHIKQ  240
			  	241  SLHEFGTDFDVYTHEDSMHTGGRVENAIARLRETGNIYEKDGATWLRTSAFGDDKDRVVI  300
			  	301  KSDGKPAYIAGDLAYYLDKRQRGFDLCIYMLGADHHGYIARLKAAAAAFGDDPATVEVLI  360
			  	361  GQMVNLVRDGQPVRMSKRAGTVLTLDDLVEAIGVDAARYSLIRSSVDTAIDIDLALWSSA  420
			  	421  SNENPVYYVQYAHARLSALARNAAELALIPDTNHLELLNHDKEGTLLRTLGEFPRVLETA  480
			  	481  ASLREPHRVCRYLEDLAGDYHRFYDSCRVLPQGDEQPTDLHTARLALCQATRQVIANGLA  540
			  	541  IIGVTAPERM

Known structures in the PDB
No Known structures
1 56 111 166 221 276 331 386 441 496 551 Range: 4 to 93  |  Coverage: 16% Arg_tRNA_synt_N Range: 101 to 414  |  Coverage: 56% tRNA-synt_1d Range: 429 to 550  |  Coverage: 22% DALR_1 Range: 5 to 550  |  Coverage: 99% 1 Range: 1 to 550  |  Coverage: 99% 1 Range: 4 to 93  |  Coverage: 16% 2 Range: 429 to 549  |  Coverage: 21% 3
Number of amino acids : 550
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Arg_tRNA_synt_NPF034854-93
tRNA-synt_1dPF00750101-414
DALR_1PF05746429-550
Mtb Structural Proteome models
Model Number1
Model nameRv1292
Template1F7U    APDBCREDO
Template coverage30_607
Template Identity(%)24.2
Model coverage(%)99.1
Normalized DOPE score0.054

Structure Models from Chopin
Model Number1
Profilea.27.1.1, c.26.1.1, d.67.2.1 - 1.10.730.10, 3.30.1360.70, 3.40.50.620
Click for model details
zscore53.51
Residue begin1
Residue end550
Model Number2
Profile3.30.1360.70
Click for model details
zscore21.38
Residue begin4
Residue end93
Model Number3
Profile1.10.730.10
Click for model details
zscore11.61
Residue begin429
Residue end549
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1292Gene nameConfidence Score
Rv1293lysA0.986
Rv1293lysA0.986
Rv3336ctrpS0.965
Rv1699pyrG0.96
Rv1699pyrG0.96
Rv1689tyrS0.959
Rv1689tyrS0.959
Rv1007cmetS0.958
Rv2572caspS0.957
Rv2572caspS0.957
Rv2572caspS0.957
Rv2580chisS0.956
Rv2580chisS0.956
Rv1017cprsA0.955
Rv1017cprsA0.955
Rv2614cthrS0.945
Rv2614cthrS0.945
Rv2614cthrS0.945
Rv0056rplI0.938
Rv0056rplI0.938
Rv1649pheS0.936
Rv1649pheS0.936
Rv3580ccysS10.935
Rv3580ccysS10.935
Rv2882cfrr0.931
Rv2992cgltS0.927
Rv3834cserS0.927
Rv3834cserS0.927
Rv2883cpyrH0.926
Rv1294thrA0.925
Rv1294thrA0.925
Rv1294thrA0.925
Rv2555calaS0.923
Rv2555calaS0.923
Rv2555calaS0.923
Rv0683rpsG0.922
Rv0053rpsF0.92
Rv1297rho0.92
Rv1297rho0.92
Rv1297rho0.92
Rv2890crpsB0.918
Rv2845cproS0.915
Rv2845cproS0.915
Rv2845cproS0.915
Rv1656argF0.914
Rv1656argF0.914
Rv0700rpsJ0.913
Rv0668rpoC0.911
Rv2839cinfB0.911
Rv0668rpoC0.911
Rv2839cinfB0.911
Rv0668rpoC0.911
Rv2839cinfB0.911
Rv0668rpoC0.911
Rv2839cinfB0.911
Rv0668rpoC0.911
Rv0041leuS0.91
Rv0041leuS0.91
Rv0041leuS0.91
Rv3458crpsD0.909
Rv3458crpsD0.909
Rv2925crnc0.909
Rv2925crnc0.909
Rv1080cgreA0.908
Rv1080cgreA0.908
Rv3459crpsK0.907
Rv3598clysS0.906
Rv3598clysS0.906
Rv2785crpsO0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
L-argininePubChem0.957174.201
pyrophosphatePubChem0.9177.975
adenosine monophosphatePubChem0.9347.221
adenosine triphosphatePubChem0.9507.181