Rv3598c

Tuberculist information
Gene namelysS
Protein functionLysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)
Functional category(tuberculist)information pathways
Gene location(kb)4041.42
Molecular mass(da)55677.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 505
	  		  	1    VSAADTAEDLPEQFRIRRDKRARLLAQGRDPYPVAVPRTHTLAEVRAAHPDLPIDTATED   60
			  	61   IVGVAGRVIFARNSGKLCFATLQDGDGTQLQVMISLDKVGQAALDAWKADVDLGDIVYVH  120
			  	121  GAVISSRRGELSVLADCWRIAAKSLRPLPVAHKEMSEESRVRQRYVDLIVRPEARAVARL  180
			  	181  RIAVVRAIRTALQRRGFLEVETPVLQTLAGGAAARPFATHSNALDIDLYLRIAPELFLKR  240
			  	241  CIVGGFDKVFELNRVFRNEGADSTHSPEFSMLETYQTYGTYDDSAVVTRELIQEVADEAI  300
			  	301  GTRQLPLPDGSVYDIDGEWATIQMYPSLSVALGEEITPQTTVDRLRGIADSLGLEKDPAI  360
			  	361  HDNRGFGHGKLIEELWERTVGKSLSAPTFVKDFPVQTTPLTRQHRSIPGVTEKWDLYLRG  420
			  	421  IELATGYSELSDPVVQRERFADQARAAAAGDDEAMVLDEDFLAALEYGMPPCTGTGMGID  480
			  	481  RLLMSLTGLSIRETVLFPIVRPHSN

Known structures in the PDB
No Known structures
1 51 101 151 201 251 301 351 401 451 501 Range: 62 to 141  |  Coverage: 15% tRNA_anti-codon Range: 156 to 502  |  Coverage: 68% tRNA-synt_2 Range: 9 to 502  |  Coverage: 97% 1 Range: 3 to 505  |  Coverage: 99% 1 Range: 156 to 502  |  Coverage: 68% 2 Range: 36 to 144  |  Coverage: 21% 3 Range: 22 to 505  |  Coverage: 95% 4
Number of amino acids : 505
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
tRNA_anti-codonPF0133662-141
tRNA-synt_2PF00152156-502
Mtb Structural Proteome models
Model Number1
Model nameRv3598c
Template1BBU    APDBCREDO
Template coverage13_502
Template Identity(%)40.1
Model coverage(%)97.6
Normalized DOPE score0.006

Structure Models from Chopin
Model Number1
Profileb.40.4.1, d.104.1.1 - 2.40.50.140, 3.30.930.10
Click for model details
zscore61.13
Residue begin3
Residue end505
Model Number2
Profile3.30.930.10
Click for model details
zscore32.48
Residue begin156
Residue end502
Model Number3
Profileb.40.4.1 - 2.40.50.140
Click for model details
zscore17.72
Residue begin36
Residue end144
Model Number4
Profile3.30.930.10
Click for model details
zscore17.29
Residue begin22
Residue end505
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3598cGene nameConfidence Score
Rv2555calaS0.978
Rv2555calaS0.978
Rv2555calaS0.978
Rv2614cthrS0.976
Rv2614cthrS0.976
Rv2614cthrS0.976
Rv1536ileS0.971
Rv1536ileS0.971
Rv3834cserS0.966
Rv3834cserS0.966
Rv1649pheS0.962
Rv1649pheS0.962
Rv2448cvalS0.953
Rv2448cvalS0.953
Rv2448cvalS0.953
Rv3336ctrpS0.953
Rv2992cgltS0.948
Rv2357cglyS0.946
Rv2357cglyS0.946
Rv3610cftsH0.927
Rv3105cprfB0.927
Rv3105cprfB0.927
Rv3610cftsH0.927
Rv3610cftsH0.927
Rv2580chisS0.925
Rv2580chisS0.925
Rv0685tuf0.921
Rv0685tuf0.921
Rv0685tuf0.921
Rv2404clepA0.92
Rv2404clepA0.92
Rv2404clepA0.92
Rv2404clepA0.92
Rv1640clysX0.916
Rv1640clysX0.916
Rv1640clysX0.916
Rv2882cfrr0.907
Rv1689tyrS0.906
Rv1292argS0.906
Rv1292argS0.906
Rv1292argS0.906
Rv1689tyrS0.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
L-lysinePubChem0.98146.188
adenosine triphosphatePubChem0.966507.181
pyrophosphatePubChem0.92177.975
adenosine monophosphatePubChem0.904347.221
glutamatePubChem0.756147.129