Rv2404c

Tuberculist information
Gene namelepA
Protein functionProbable GTP-binding protein LepA (GTP-binding elongation factor)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2701.29
Molecular mass(da)72363.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 653
	  		  	1    VRTPCSQHRRDRPSAIGSQLPDADTLDTRQPPLQEIPISSFADKTFTAPAQIRNFCIIAH   60
			  	61   IDHGKSTLADRMLQLTGVVDERSMRAQYLDRMDIERERGITIKAQNVRLPWRVDKTDYVL  120
			  	121  HLIDTPGHVDFTYEVSRALEACEGAVLLVDAAQGIEAQTLANLYLALDRDLHIIPVLNKI  180
			  	181  DLPAADPDRYAAEMAHIIGCEPAEVLRVSGKTGEGVSDLLDEVVRQVPPPQGDAEAPTRA  240
			  	241  MIFDSVYDIYRGVVTYVRVVDGKISPRERIMMMSTGATHELLEVGIVSPEPKPCEGLGVG  300
			  	301  EVGYLITGVKDVRQSKVGDTVTSLSRARGAAAEALTGYREPKPMVYSGLYPVDGSDYPNL  360
			  	361  RDALDKLQLNDAALTYEPETSVALGFGFRCGFLGLLHMEITRERLEREFGLDLISTSPNV  420
			  	421  VYRVHKDDGTEIRVTNPSDWPEGKIRTVYEPVVKTTIIAPSEFIGTIMELCQSRRGELGG  480
			  	481  MDYLSPERVELRYTMPLGEIIFDFFDALKSRTRGYASLDYEEAGEQEAALVKVDILLQGE  540
			  	541  AVDAFSAIVHKDTAYAYGNKMTTKLKELIPRQQFEVPVQAAIGSKIIARENIRAIRKDVL  600
			  	601  SKCYGGDITRKRKLLEKQKEGKKRMKTIGRVEVPQEAFVAALSTDAAGDKGKK

Known structures in the PDB
No Known structures
1 66 131 196 261 326 391 456 521 586 651 Range: 50 to 229  |  Coverage: 27% GTP_EFTU Range: 252 to 322  |  Coverage: 10% GTP_EFTU_D2 Range: 447 to 536  |  Coverage: 13% EFG_C Range: 537 to 644  |  Coverage: 16% LepA_C Range: 40 to 652  |  Coverage: 93% 1 Range: 49 to 649  |  Coverage: 91% 1 Range: 340 to 421  |  Coverage: 12% 2 Range: 447 to 536  |  Coverage: 13% 3 Range: 50 to 229  |  Coverage: 27% 4 Range: 340 to 624  |  Coverage: 43% 5 Range: 84 to 476  |  Coverage: 60% 6 Range: 11 to 370  |  Coverage: 54% 7
Number of amino acids : 653
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GTP_EFTUPF0000950-229
GTP_EFTU_D2PF03144252-322
EFG_CPF00679447-536
LepA_CPF06421537-644
Mtb Structural Proteome models
Model Number1
Model nameRv2404c
Template1N0U    APDBCREDO
Template coverage7_791
Template Identity(%)17.0
Model coverage(%)93.7
Normalized DOPE score1.186

Structure Models from Chopin
Model Number1
Profileb.43.3.1, c.37.1.8, d.14.1.1, d.58.11.1 - 2.40.30.10, 3.30.70.870, 3.40.50.300
Click for model details
zscore23.72
Residue begin49
Residue end649
Model Number2
Profile3.30.70.870
Click for model details
zscore14.78
Residue begin340
Residue end421
Model Number3
Profile3.30.70.240
Click for model details
zscore13.66
Residue begin447
Residue end536
Model Number4
Profilec.37.1.8 - 3.40.50.300
Click for model details
zscore11.34
Residue begin50
Residue end229
Model Number5
Profile2.40.50.250, 3.30.70.240, 3.30.70.870
Click for model details
zscore11.2
Residue begin340
Residue end624
Model Number6
Profilec.37.1.8, d.52.5.1 - 3.30.300.20, 3.40.50.300
Click for model details
zscore10.57
Residue begin84
Residue end476
Model Number7
Profilec.37.1.8 - 3.40.50.300
Click for model details
zscore8.56
Residue begin11
Residue end370
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2404cGene nameConfidence Score
Rv2364cera0.977
Rv2364cera0.977
Rv2440cobg0.976
Rv2440cobg0.976
Rv2440cobg0.976
Rv1699pyrG0.97
Rv1699pyrG0.97
Rv2925crnc0.967
Rv2925crnc0.967
Rv1112Rv11120.953
Rv1112Rv11120.953
Rv2388chemN0.952
Rv2388chemN0.952
Rv2916cffh0.951
Rv2374chrcA0.951
Rv2916cffh0.951
Rv2374chrcA0.951
Rv2916cffh0.951
Rv1713engA0.947
Rv1713engA0.947
Rv2534cefp0.94
Rv2534cefp0.94
Rv2534cefp0.94
Rv2166cRv2166c0.937
Rv2903clepB0.935
Rv2903clepB0.935
Rv0041leuS0.933
Rv0041leuS0.933
Rv0041leuS0.933
Rv1406fmt0.931
Rv1406fmt0.931
Rv2992cgltS0.927
Rv2793ctruB0.924
Rv2793ctruB0.924
Rv3336ctrpS0.924
Rv3598clysS0.92
Rv3598clysS0.92
Rv0350dnaK0.92
Rv2448cvalS0.918
Rv2448cvalS0.918
Rv2448cvalS0.918
Rv3356cfolD0.915
Rv3356cfolD0.915
Rv1536ileS0.909
Rv1536ileS0.909
Rv2614cthrS0.906
Rv2614cthrS0.906
Rv2614cthrS0.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
guanosine triphosphatePubChem0.701523.18