Rv2374c

Tuberculist information
Gene namehrcA
Protein functionProbable heat shock protein transcriptional repressor HrcA
Functional category(tuberculist)virulence,detoxification and adaptaion
Gene location(kb)2654.06
Molecular mass(da)36474.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 343
	  		  	1    MGSADERRFEVLRAIVADFVATQEPIGSKSLVERHNLGVSSATVRNDMAVLEAEGYITQP   60
			  	61   HTSSGRVPTEKGYREFVDRLEDVKPLSSAERRAIQSFLESGVDLDDVLRRAVRLLAQLTR  120
			  	121  QVAVVQYPTLSTSTVRHLEVIALTPARLLMVVITDSGRVDQRIVELGDVIDDHQLAQLRE  180
			  	181  ILGQALEGKKLSAASVAVADLASQLGGAGGLGDAVGRAATVLLESLVEHTEERLLLGGTA  240
			  	241  NLTRNAADFGGSLRSILEALEEQVVVLRLLAAQQEAGKVTVRIGHETASEQMVGTSMVST  300
			  	301  AYGTAHTVYGGMGVVGPTRMDYPGTIASVAAVALYIGDVLGAR

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 9 to 84  |  Coverage: 21% HrcA_DNA-bdg Range: 104 to 326  |  Coverage: 64% HrcA Range: 3 to 342  |  Coverage: 98% 1 Range: 1 to 343  |  Coverage: 99% 1 Range: 99 to 343  |  Coverage: 71% 2 Range: 1 to 84  |  Coverage: 24% 3
Number of amino acids : 343
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
HrcA_DNA-bdgPF034449-84
HrcAPF01628104-326
Mtb Structural Proteome models
Model Number1
Model nameRv2374c
Template1STZ    APDBCREDO
Template coverage14_334
Template Identity(%)25.5
Model coverage(%)98.8
Normalized DOPE score-0.065

Structure Models from Chopin
Model Number1
Profilea.4.5.51, d.110.2.3 - 1.10.10.10, 3.30.390.60, 3.30.450.40
Click for model details
zscore42.85
Residue begin1
Residue end343
Model Number2
Profiled.110.2.3
Click for model details
zscore36.16
Residue begin99
Residue end343
Model Number3
Profilea.4.5.51
Click for model details
zscore26.06
Residue begin1
Residue end84
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2374cGene nameConfidence Score
Rv0350dnaK0.999
Rv0351grpE0.992
Rv3417cgroEL10.99
Rv0384cclpB0.987
Rv0384cclpB0.987
Rv0384cclpB0.987
Rv0384cclpB0.987
Rv0440groEL20.984
Rv3596cclpC10.978
Rv3596cclpC10.978
Rv3596cclpC10.978
Rv3596cclpC10.978
Rv3596cclpC10.978
Rv2372cRv2372c0.977
Rv2373cdnaJ20.975
Rv2373cdnaJ20.975
Rv2373cdnaJ20.975
Rv2461cclpP10.974
Rv2404clepA0.951
Rv2404clepA0.951
Rv2404clepA0.951
Rv2404clepA0.951
Rv2388chemN0.944
Rv2388chemN0.944
Rv0352dnaJ10.937
Rv0352dnaJ10.937
Rv0352dnaJ10.937
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions