Rv2372c

Tuberculist information
Gene nameRv2372c
Protein functionConserved hypothetical protein
Functional category(tuberculist)conserved hypotheticals
Gene location(kb)2652.04
Molecular mass(da)27652.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 262
	  		  	1    MVAMLFYVDTLPDTGAVAVVDGDEGFHAATVRRIRPGEQLVLGDGVGRLARCVVEQAGRG   60
			  	61   GLRARVLRRWSVPPVRPPVTVVQALPKSERSELAIELATEAGADAFLAWQAARCVANWDG  120
			  	121  ARVDKGLRRWRAVVRSAARQSRRARIPPVDGVLSTPMLVQRVREEVAAGAAVLVLHEEAT  180
			  	181  ERIVDIAAAQAGSLMLVVGPEGGIAPDELAALTDAGAVAVRLGPTVLRTSTAAAVALGAV  240
			  	241  GVLTSRWDASASDCEYCDVTRR

Known structures in the PDB
PDB ID4L69
Total residue count263
Number of chains1
MethodX-RAY
Resolution2.9
1 27 53 79 105 131 157 183 209 235 261 Range: 18 to 242  |  Coverage: 85% Methyltrans_RNA Range: 4 to 248  |  Coverage: 93% 1 Range: 3 to 251  |  Coverage: 94% 1 Range: 72 to 251  |  Coverage: 68% 2 Range: 3 to 76  |  Coverage: 27% 3
Number of amino acids : 262
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Methyltrans_RNAPF0445218-242
Mtb Structural Proteome models
Model Number1
Model nameRv2372c
Template1VHK    APDBCREDO
Template coverage2_253
Template Identity(%)30.2
Model coverage(%)93.1
Normalized DOPE score0.206

Structure Models from Chopin
Model Number1
Profileb.122.1.2, c.116.1.5 - 2.40.240.20, 3.40.1280.10
Click for model details
zscore37.32
Residue begin3
Residue end251
Model Number2
Profilec.116.1.5
Click for model details
zscore37
Residue begin72
Residue end251
Model Number3
Profileb.122.1.2
Click for model details
zscore10.51
Residue begin3
Residue end76
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2372cGene nameConfidence Score
Rv2374chrcA0.977
Rv2374chrcA0.977
Rv1010ksgA0.947
Rv2373cdnaJ20.94
Rv2373cdnaJ20.94
Rv2373cdnaJ20.94
Rv2966cRv2966c0.916
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
selenomethioninePubChem0.797196.106
SeMetPubChem0.797196.106