Rv1010

Tuberculist information
Gene nameksgA
Protein functionProbable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (high level kasugamycin resistance protein KsgA) (kasugamycin dimethyltransferase)
Functional category(tuberculist)information pathways
Gene location(kb)1129.15
Molecular mass(da)34645.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 317
	  		  	1    MCCTSGCALTIRLLGRTEIRRLAKELDFRPRKSLGQNFVHDANTVRRVVAASGVSRSDLV   60
			  	61   LEVGPGLGSLTLALLDRGATVTAVEIDPLLASRLQQTVAEHSHSEVHRLTVVNRDVLALR  120
			  	121  REDLAAAPTAVVANLPYNVAVPALLHLLVEFPSIRVVTVMVQAEVAERLAAEPGSKEYGV  180
			  	181  PSVKLRFFGRVRRCGMVSPTVFWPIPRVYSGLVRIDRYETSPWPTDDAFRRRVFELVDIA  240
			  	241  FAQRRKTSRNAFVQWAGSGSESANRLLAASIDPARRGETLSIDDFVRLLRRSGGSDEATS  300
			  	301  TGRDARAPDISGHASAS

Known structures in the PDB
No Known structures
1 32 63 94 125 156 187 218 249 280 311 Range: 27 to 291  |  Coverage: 83% RrnaAD Range: 36 to 311  |  Coverage: 86% 1 Range: 28 to 317  |  Coverage: 91% 1
Number of amino acids : 317
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
RrnaADPF0039827-291
Mtb Structural Proteome models
Model Number1
Model nameRv1010
Template1ZQ9    APDBCREDO
Template coverage36_296
Template Identity(%)31.4
Model coverage(%)86.5
Normalized DOPE score-0.135

Structure Models from Chopin
Model Number1
Profilec.66.1.24
Click for model details
zscore43.06
Residue begin28
Residue end317
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1010Gene nameConfidence Score
Rv1011ispE0.995
Rv1011ispE0.995
Rv2906ctrmD0.982
Rv1007cmetS0.976
Rv2793ctruB0.973
Rv2793ctruB0.973
Rv1112Rv11120.97
Rv1112Rv11120.97
Rv1008tatD0.966
Rv0682rpsL0.963
Rv1009rpfB0.962
Rv1009rpfB0.962
Rv1009rpfB0.962
Rv2372cRv2372c0.947
Rv3442crpsI0.945
Rv2992cgltS0.929
Rv3411cguaB20.924
Rv1689tyrS0.924
Rv3411cguaB20.924
Rv1689tyrS0.924
Rv1406fmt0.921
Rv1406fmt0.921
Rv3834cserS0.917
Rv3834cserS0.917
Rv3715crecR0.914
Rv3459crpsK0.914
Rv3715crecR0.914
Rv3715crecR0.914
Rv2118cRv2118c0.913
Rv3924crpmH0.913
Rv2118cRv2118c0.913
Rv3396cguaA0.908
Rv3396cguaA0.908
Rv3396cguaA0.908
Rv0639nusG0.906
Rv0639nusG0.906
Rv3455ctruA0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
S-adenosyl-L-methioninePubChem0.894399.445
adenosinePubChem0.888267.241
S-adenosylhomocysteinePubChem0.851384.411
kasugamycinPubChem0.788379.363