Rv3459c

Tuberculist information
Gene namerpsK
Protein function30S ribosomal protein S11 RpsK
Functional category(tuberculist)information pathways
Gene location(kb)3879.27
Molecular mass(da)14784.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 139
	  		  	1    MPPAKKGPATSARKGQKTRRREKKNVPHGAAHIKSTFNNTIVTITDPQGNVIAWASSGHV   60
			  	61   GFKGSRKSTPFAAQLAAENAARKAQDHGVRKVDVFVKGPGSGRETAIRSLQAAGLEVGAI  120
			  	121  SDVTPQPHNGVRPPKRRRV

Known structures in the PDB
No Known structures
1 14 27 40 53 66 79 92 105 118 131 Range: 29 to 138  |  Coverage: 78% Ribosomal_S11 Range: 23 to 139  |  Coverage: 83% 1 Range: 23 to 139  |  Coverage: 83% 1
Number of amino acids : 139
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribosomal_S11PF0041129-138
Mtb Structural Proteome models
Model Number1
Model nameRv3459c
Template2AVY    KPDBCREDO
Template coverage12_128
Template Identity(%)60.7
Model coverage(%)83.5
Normalized DOPE score-0.499

Structure Models from Chopin
Model Number1
Profilec.55.4.1 - 3.30.420.80
Click for model details
zscore28.05
Residue begin23
Residue end139
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3459cGene nameConfidence Score
Rv0718rpsH0.999
Rv3458crpsD0.999
Rv0705rpsS0.999
Rv0700rpsJ0.999
Rv3460crpsM0.999
Rv0707rpsC0.999
Rv0721rpsE0.999
Rv0707rpsC0.999
Rv0721rpsE0.999
Rv3442crpsI0.999
Rv3458crpsD0.999
Rv0682rpsL0.998
Rv0708rplP0.998
Rv0704rplB0.998
Rv0704rplB0.998
Rv0710rpsQ0.997
Rv0714rplN0.997
Rv3456crplQ0.997
Rv0701rplC0.997
Rv3457crpoA0.997
Rv0716rplE0.997
Rv3457crpoA0.997
Rv0716rplE0.997
Rv3457crpoA0.997
Rv0683rpsG0.997
Rv0717rpsN10.997
Rv0685tuf0.996
Rv0719rplF0.996
Rv2890crpsB0.996
Rv0702rplD0.996
Rv0685tuf0.996
Rv0685tuf0.996
Rv0684fusA10.995
Rv0640rplK0.995
Rv0684fusA10.995
Rv0640rplK0.995
Rv0715rplX0.995
Rv0684fusA10.995
Rv0684fusA10.995
Rv0651rplJ0.995
Rv0684fusA10.995
Rv1641infC0.994
Rv0706rplV0.994
Rv0641rplA0.994
Rv2056crpsN20.994
Rv1641infC0.994
Rv0723rplO0.994
Rv0720rplR0.993
Rv0652rplL0.993
Rv0667rpoB0.992
Rv0667rpoB0.992
Rv0667rpoB0.992
Rv0667rpoB0.992
Rv0703rplW0.992
Rv0667rpoB0.992
Rv0667rpoB0.992
Rv3443crplM0.992
Rv0722rpmD0.991
Rv0732secY0.99
Rv2785crpsO0.988
Rv2909crpsP0.988
Rv0053rpsF0.987
Rv1023eno0.986
Rv2904crplS0.986
Rv1023eno0.986
Rv0734mapA0.985
Rv3462cinfA0.984
Rv0668rpoC0.982
Rv0668rpoC0.982
Rv2441crpmA0.982
Rv0668rpoC0.982
Rv0668rpoC0.982
Rv0056rplI0.982
Rv0056rplI0.982
Rv0668rpoC0.982
Rv3100csmpB0.981
Rv2861cmapB0.979
Rv0733adk0.977
Rv0709rpmC0.974
Rv2412rpsT0.971
Rv1643rplT0.971
Rv2916cffh0.97
Rv2916cffh0.97
Rv3461crpmJ0.97
Rv2916cffh0.97
Rv3455ctruA0.968
Rv2906ctrmD0.967
Rv2882cfrr0.967
Rv2889ctsf0.964
Rv2889ctsf0.964
Rv1297rho0.963
Rv1297rho0.963
Rv1297rho0.963
Rv0639nusG0.962
Rv0639nusG0.962
Rv1630rpsA0.959
Rv0055rpsR10.957
Rv1699pyrG0.953
Rv2442crplU0.953
Rv1699pyrG0.953
Rv1649pheS0.952
Rv1649pheS0.952
Rv1650pheT0.938
Rv1650pheT0.938
Rv1650pheT0.938
Rv1650pheT0.938
Rv0120cfusA20.935
Rv0120cfusA20.935
Rv1308atpA0.935
Rv0120cfusA20.935
Rv1308atpA0.935
Rv0120cfusA20.935
Rv1308atpA0.935
Rv0120cfusA20.935
Rv2534cefp0.934
Rv2534cefp0.934
Rv2534cefp0.934
Rv2839cinfB0.929
Rv2839cinfB0.929
Rv2839cinfB0.929
Rv2839cinfB0.929
Rv2448cvalS0.926
Rv2448cvalS0.926
Rv2448cvalS0.926
Rv0350dnaK0.92
Rv2058crpmB20.919
Rv1010ksgA0.914
Rv2793ctruB0.911
Rv2793ctruB0.911
Rv2057crpmG10.908
Rv1292argS0.907
Rv1292argS0.907
Rv3436cglmS0.907
Rv1292argS0.907
Rv3436cglmS0.907
Rv1298rpmE0.906
Rv1007cmetS0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
spectinomycinPubChem0.794332.35
magnesiumPubChem0.78824.305
guanosine diphosphatePubChem0.788443.201
5-methylcytidylic acidPubChem0.707337.223
adenosine 3',5'-diphosphatePubChem0.707427.201
[3,4-dihydroxy-5-(6-imino-1-methyl-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.707361.248
pactamycinPubChem0.707558.623
adenosine monophosphatePubChem0.707347.221
C04639PubChem0.707326.197
polyuridylic acidPubChem0.707324.181
pseudouridine 5'-phosphatePubChem0.707324.181
CSIPubChem0.707172.185
kasugamycinPubChem0.707379.363
2,3-diaminopropionic acidPubChem0.707104.108
phenylalaninalPubChem0.707149.19
MYC-8003PubChem0.707796.943
7mgPubChem0.707379.263
UD29PubChem0.707340.247
kirromycinPubChem0.707796.943
[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl phosphatePubChem0.707338.208
2'-O-methylguanosine 5'-monophosphatePubChem0.707377.247
potassiumPubChem0.70739.0983
L-2,3-diaminopropionic acidPubChem0.707104.108
[5-(2-dimethylamino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic AcidPubChem0.707391.274
streptomycinPubChem0.707581.574
3'-phosphoadenosine 5'-phosphatePubChem0.707427.201
poly(2'-O-methylcytidylic acid)PubChem0.707337.223
pseudouridylic acidPubChem0.707324.181
L-beta-lysinePubChem0.707146.188
DB08185PubChem0.707463.446
zincPubChem0.70765.409
poly CPubChem0.707323.197
3'-amino-3'-deoxy AMPPubChem0.707346.236
2-mercaptoethanolPubChem0.70778.1334
CHEBI:603702PubChem0.707558.623
poly(2'-O-methyladenylic acid)PubChem0.707361.248
beta-lysinePubChem0.707146.188
methyl 4-[3-[3,4-dihydroxy-5-(phosphonooxymethyl)oxolan-2-yl]-4,6-dimethyl-9-oxoimidazo[1,2-a]purin-PubChem0.707588.462
fusidic acidPubChem0.707516.709
[(2R,3S,4R,5R)-5-[2-(dimethylamino)-6-oxo-3H-purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen PubChem0.707391.274
ara-TMPPubChem0.707338.208
guanylatePubChem0.707363.221
potassium hydridePubChem0.70740.1062
[3,4-dihydroxy-5-(2-methylamino-6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.707377.247
guanylyl-(alpha,beta)-methylene-diphosphonatePubChem0.707521.208
C07026PubChem0.707346.236