Rv1650

Tuberculist information
Gene namepheT
Protein functionProbable phenylalanyl-tRNA synthetase, beta chain PheT
Functional category(tuberculist)information pathways
Gene location(kb)1859.76
Molecular mass(da)88374
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 831
	  		  	1    MRLPYSWLREVVAVGASGWDVTPGELEQTLLRIGHEVEEVIPLGPVDGPVTVGRVADIEE   60
			  	61   LTGYKKPIRACAVDIGDRQYREIICGATNFAVGDLVVVALPGATLPGGFTISARKAYGRN  120
			  	121  SDGMICSAAELNLGADHSGILVLPPGAAEPGADGAGVLGLDDVVFHLAITPDRGYCMSVR  180
			  	181  GLARELACAYDLDFVDPASNSRVPPLPIEGPAWPLTVQPETGVRRFALRPVIGIDPAAVS  240
			  	241  PWWLQRRLLLCGIRATCPAVDVTNYVMLELGHPMHAHDRNRISGTLGVRFARSGETAVTL  300
			  	301  DGIERKLDTADVLIVDDAATAAIGGVMGAASTEVRADSTDVLLEAAIWDPAAVSRTQRRL  360
			  	361  HLPSEAARRYERTVDPAISVAALDRCARLLADIAGGEVSPTLTDWRGDPPCDDWSPPPIR  420
			  	421  MGVDVPDRIAGVAYPQGTTARRLAQIGAVVTHDGDTLTVTPPSWRPDLRQPADLVEEVLR  480
			  	481  LEGLEVIPSVLPPAPAGRGLTAGQQRRRTIGRSLALSGYVEILPTPFLPAGVFDLWGLEA  540
			  	541  DDSRRMTTRVLNPLEADRPQLATTLLPALLEALVRNVSRGLVDVALFAIAQVVQPTEQTR  600
			  	601  GVGLIPVDRRPTDDEIAMLDASLPRQPQHVAAVLAGLREPRGPWGPGRPVEAADAFEAVR  660
			  	661  IIARASRVDVTLRPAQYLPWHPGRCAQVFVGESSVGHAGQLHPAVIERSGLPKGTCAVEL  720
			  	721  NLDAIPCSAPLPAPRVSPYPAVFQDVSLVVAADIPAQAVADAVRAGAGDLLEDIALFDVF  780
			  	781  TGPQIGEHRKSLTFALRFRAPDRTLTEDDASAARDAAVQSAAERVGAVLRG

Known structures in the PDB
No Known structures
1 84 167 250 333 416 499 582 665 748 831 Range: 50 to 153  |  Coverage: 12% tRNA_bind Range: 222 to 395  |  Coverage: 20% B3_4 Range: 416 to 484  |  Coverage: 8% B5 Range: 737 to 830  |  Coverage: 11% FDX-ACB Range: 1 to 830  |  Coverage: 99% 1 Range: 1 to 831  |  Coverage: 99% 1 Range: 222 to 395  |  Coverage: 20% 2 Range: 50 to 153  |  Coverage: 12% 3 Range: 731 to 831  |  Coverage: 12% 4 Range: 414 to 489  |  Coverage: 9% 5 Range: 124 to 196  |  Coverage: 8% 6
Number of amino acids : 831
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
tRNA_bindPF0158850-153
B3_4PF03483222-395
B5PF03484416-484
FDX-ACBPF03147737-830
Mtb Structural Proteome models
Model Number1
Model nameRv1650
Template1B7Y    BPDBCREDO
Template coverage1_773
Template Identity(%)37.5
Model coverage(%)99.8
Normalized DOPE score0.67

Structure Models from Chopin
Model Number1
Profilea.6.1.1, b.153.1.1, b.40.4.4, d.104.1.1, d.58.13.1 - 2.40.50.140, 3.30.56.10, 3.30.56.20, 3.30.70.380, 3.30.930.10, 3.50.40.10
Click for model details
zscore106.98
Residue begin1
Residue end831
Model Number2
Profileb.153.1.1
Click for model details
zscore49.81
Residue begin222
Residue end395
Model Number3
Profileb.40.4.4
Click for model details
zscore24.81
Residue begin50
Residue end153
Model Number4
Profiled.58.13.1
Click for model details
zscore24.54
Residue begin731
Residue end831
Model Number5
Profile3.30.56.20
Click for model details
zscore21.03
Residue begin414
Residue end489
Model Number6
Profile3.30.56.10
Click for model details
zscore20.67
Residue begin124
Residue end196
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1650Gene nameConfidence Score
Rv1649pheS0.999
Rv1649pheS0.999
Rv2364cera0.959
Rv2364cera0.959
Rv2555calaS0.945
Rv2555calaS0.945
Rv2555calaS0.945
Rv1630rpsA0.94
Rv3459crpsK0.938
Rv3100csmpB0.926
Rv1007cmetS0.916
Rv1643rplT0.902
Rv0006gyrA0.901
Rv0006gyrA0.901
Rv0706rplV0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
L-phenylalaninePubChem0.964165.189
sulfatePubChem0.7796.0626
hydron sulfatePubChem0.77196.157
magnesiumPubChem0.75224.305
selenomethioninePubChem0.731196.106
SeMetPubChem0.731196.106