SInCRe - Rv2364c

Tuberculist information

Gene name	era
Protein function	Probable GTP-binding protein Era
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	2645.77
Molecular mass(da)	32460.4
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 300

	  		  	1    MTEFHSGFVCLVGRPNTGKSTLTNALVGAKVAITSTRPQTTRHAIRGIVHSDDFQIILVD   60
			  	61   TPGLHRPRTLLGKRLNDLVRETYAAVDVIGLCIPADEAIGPGDRWIVEQLRSTGPANTTL  120
			  	121  VVIVTKIDKVPKEKVVAQLVAVSELVTNAAEIVPVSAMTGDRVDLLIDVLAAALPAGPAY  180
			  	181  YPDGELTDEPEEVLMAELIREAALQGVRDELPHSLAVVIDEVSPREGRDDLIDVHAALYV  240
			  	241  ERDSQKGIVIGKGGARLREVGTAARSQIENLLGTKVYLDLRVKVAKNWQRDPKQLGRLGF  300

Known structures in the PDB

	PDB ID	1YGY
	Total residue count	1058
	Number of chains	2
	Method	X-RAY
	Resolution	2.3

	PDB ID	3DC2
	Total residue count	1058
	Number of chains	2
	Method	X-RAY
	Resolution	2.7

	PDB ID	3DDN
	Total residue count	1056
	Number of chains	2
	Method	X-RAY
	Resolution	2.4

Number of amino acids : 300

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
MMR_HSR1	PF01926	8-126
KH_2	PF07650	210-289

Mtb Structural Proteome models

Model Number	1
Model name	Rv2364c
Template	1WF3 APDB CREDO
Template coverage	3_296
Template Identity(%)	40.1
Model coverage(%)	99.3
Normalized DOPE score	-1.032

Structure Models from Chopin

Model Number	1
Profile	3.30.300.20 Click for model details
zscore	9.05
Residue begin	181
Residue end	300

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv2364c	Gene name	Confidence Score
Rv2404c	lepA	0.977
Rv2404c	lepA	0.977
Rv2404c	lepA	0.977
Rv2404c	lepA	0.977
Rv1650	pheT	0.959
Rv1650	pheT	0.959
Rv1650	pheT	0.959
Rv1650	pheT	0.959
Rv0056	rplI	0.931
Rv0056	rplI	0.931
Rv3100c	smpB	0.925
Rv1630	rpsA	0.924
Rv2925c	rnc	0.924
Rv2925c	rnc	0.924
Rv2367c	Rv2367c	0.92
Rv2368c	phoH1	0.92
Rv2368c	phoH1	0.92
Rv2366c	Rv2366c	0.915
Rv0707	rpsC	0.915
Rv0707	rpsC	0.915
Rv2366c	Rv2366c	0.915
Rv2366c	Rv2366c	0.915
Rv1007c	metS	0.903

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
magnesiumPubChem	0.849	24.305
Gpp(NH)pPubChem	0.806	522.196
sulfatePubChem	0.784	96.0626
hydron sulfatePubChem	0.784	196.157
guanosine diphosphatePubChem	0.772	443.201