Rv1007c

Tuberculist information
Gene namemetS
Protein functionMethionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase)
Functional category(tuberculist)information pathways
Gene location(kb)1125.44
Molecular mass(da)58092.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 519
	  		  	1    MKPYYVTTAIAYPNAAPHVGHAYEYIATDAIARFKRLDRYDVRFLTGTDEHGLKVAQAAA   60
			  	61   AAGVPTAALARRNSDVFQRMQEALNISFDRFIRTTDADHHEASKELWRRMSAAGDIYLDN  120
			  	121  YSGWYSVRDERFFVESETQLVDGTRLTVETGTPVTWTEEQTYFFRLSAYTDKLLAHYHAN  180
			  	181  PDFIAPETRRNEVISFVSGGLDDLSISRTSFDWGVQVPEHPDHVMYVWVDALTNYLTGAG  240
			  	241  FPDTDSELFRRYWPADLHMIGKDIIRFHAVYWPAFLMSAGIELPRRIFAHGFLHNRGEKM  300
			  	301  SKSVGNIVDPVALAEALGVDQVRYFLLREVPFGQDGSYSDEAIVTRINTDLANELGNLAQ  360
			  	361  RSLSMVAKNLDGRVPNPGEFADADAALLATADGLLERVRGHFDAQAMHLALEAIWLMLGD  420
			  	421  ANKYFSVQQPWVLRKSESEADQARFRTTLYVTCEVVRIAALLIQPVMPESAGKILDLLGQ  480
			  	481  APNQRSFAAVGVRLTPGTALPPPTGVFPRYQPPQPPEGK

Known structures in the PDB
No Known structures
1 52 103 154 205 256 307 358 409 460 511 Range: 4 to 363  |  Coverage: 69% tRNA-synt_1g Range: 2 to 509  |  Coverage: 97% 1 Range: 1 to 510  |  Coverage: 98% 1 Range: 115 to 227  |  Coverage: 21% 2 Range: 384 to 489  |  Coverage: 20% 3 Range: 348 to 519  |  Coverage: 32% 4
Number of amino acids : 519
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
tRNA-synt_1gPF093344-363
Mtb Structural Proteome models
Model Number1
Model nameRv1007c
Template1A8H    APDBCREDO
Template coverage3_499
Template Identity(%)41.9
Model coverage(%)97.7
Normalized DOPE score-0.598

Structure Models from Chopin
Model Number1
Profilea.27.1.1, c.26.1.1 - 1.10.730.10, 2.170.220.10, 3.40.50.620
Click for model details
zscore91.82
Residue begin1
Residue end510
Model Number2
Profile2.170.220.10
Click for model details
zscore29.52
Residue begin115
Residue end227
Model Number3
Profilea.27.1.1
Click for model details
zscore11.95
Residue begin384
Residue end489
Model Number4
Profilea.27.1.1
Click for model details
zscore10.42
Residue begin348
Residue end519
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1007cGene nameConfidence Score
Rv1112Rv11120.987
Rv1112Rv11120.987
Rv1406fmt0.981
Rv1406fmt0.981
Rv1649pheS0.976
Rv1649pheS0.976
Rv1010ksgA0.976
Rv2992cgltS0.975
Rv1133cmetE0.971
Rv1133cmetE0.971
Rv1008tatD0.966
Rv1689tyrS0.961
Rv1689tyrS0.961
Rv1292argS0.958
Rv1292argS0.958
Rv2580chisS0.958
Rv1292argS0.958
Rv2580chisS0.958
Rv3721cdnaZX0.944
Rv3721cdnaZX0.944
Rv2555calaS0.941
Rv2555calaS0.941
Rv2555calaS0.941
Rv2440cobg0.939
Rv2440cobg0.939
Rv2440cobg0.939
Rv2124cmetH0.935
Rv0684fusA10.935
Rv0684fusA10.935
Rv2124cmetH0.935
Rv0684fusA10.935
Rv2124cmetH0.935
Rv0684fusA10.935
Rv2124cmetH0.935
Rv0684fusA10.935
Rv2124cmetH0.935
Rv3602cpanC0.934
Rv0006gyrA0.932
Rv0006gyrA0.932
Rv2572caspS0.928
Rv2572caspS0.928
Rv2572caspS0.928
Rv2614cthrS0.927
Rv2614cthrS0.927
Rv2614cthrS0.927
Rv3336ctrpS0.925
Rv2534cefp0.922
Rv2534cefp0.922
Rv2839cinfB0.922
Rv2534cefp0.922
Rv2839cinfB0.922
Rv3248csahH0.922
Rv2839cinfB0.922
Rv3248csahH0.922
Rv2839cinfB0.922
Rv1650pheT0.916
Rv1650pheT0.916
Rv1650pheT0.916
Rv1650pheT0.916
Rv2845cproS0.915
Rv2845cproS0.915
Rv2845cproS0.915
Rv0721rpsE0.908
Rv0721rpsE0.908
Rv2364cera0.903
Rv2364cera0.903
Rv3834cserS0.903
Rv3834cserS0.903
Rv3459crpsK0.903
Rv1630rpsA0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
L-methioninePubChem0.973149.211
adenosine triphosphatePubChem0.9507.181
pyrophosphatePubChem0.9177.975
SeMetPubChem0.9196.106
adenosine monophosphatePubChem0.9347.221
selenomethioninePubChem0.9196.106
zincPubChem0.81165.409
DB02229PubChem0.746479.532
adenosinePubChem0.74267.241