Rv0684

Tuberculist information
Gene namefusA1
Protein functionProbable elongation factor G FusA1 (EF-G)
Functional category(tuberculist)information pathways
Gene location(kb)782.485
Molecular mass(da)77170.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 701
	  		  	1    VAQKDVLTDLSRVRNFGIMAHIDAGKTTTTERILYYTGINYKIGEVHDGAATMDWMEQEQ   60
			  	61   ERGITITSAATTTFWKDNQLNIIDTPGHVDFTVEVERNLRVLDGAVAVFDGKEGVEPQSE  120
			  	121  QVWRQADKYDVPRICFVNKMDKIGADFYFSVRTMGERLGANAVPIQLPVGAEADFEGVVD  180
			  	181  LVEMNAKVWRGETKLGETYDTVEIPADLAEQAEEYRTKLLEVVAESDEHLLEKYLGGEEL  240
			  	241  TVDEIKGAIRKLTIASEIYPVLCGSAFKNKGVQPMLDAVVDYLPSPLDVPPAIGHAPAKE  300
			  	301  DEEVVRKATTDEPFAALAFKIATHPFFGKLTYIRVYSGTVESGSQVINATKGKKERLGKL  360
			  	361  FQMHSNKENPVDRASAGHIYAVIGLKDTTTGDTLSDPNQQIVLESMTFPDPVIEVAIEPK  420
			  	421  TKSDQEKLSLSIQKLAEEDPTFKVHLDSETGQTVIGGMGELHLDILVDRMRREFKVEANV  480
			  	481  GKPQVAYKETIKRLVQNVEYTHKKQTGGSGQFAKVIINLEPFTGEEGATYEFESKVTGGR  540
			  	541  IPREYIPSVDAGAQDAMQYGVLAGYPLVNLKVTLLDGAYHEVDSSEMAFKIAGSQVLKKA  600
			  	601  AALAQPVILEPIMAVEVTTPEDYMGDVIGDLNSRRGQIQAMEERAGARVVRAHVPLSEMF  660
			  	661  GYVGDLRSKTQGRANYSMVFDSYSEVPANVSKEIIAKATGE

Known structures in the PDB
No Known structures
1 71 141 211 281 351 421 491 561 631 701 Range: 11 to 285  |  Coverage: 39% GTP_EFTU Range: 328 to 395  |  Coverage: 9% GTP_EFTU_D2 Range: 408 to 482  |  Coverage: 10% EFG_II Range: 483 to 605  |  Coverage: 17% EFG_IV Range: 607 to 694  |  Coverage: 12% EFG_C Range: 9 to 695  |  Coverage: 97% 1 Range: 10 to 701  |  Coverage: 98% 1 Range: 408 to 486  |  Coverage: 11% 2 Range: 607 to 694  |  Coverage: 12% 3 Range: 483 to 605  |  Coverage: 17% 4 Range: 405 to 522  |  Coverage: 16% 5
Number of amino acids : 701
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GTP_EFTUPF0000911-285
GTP_EFTU_D2PF03144328-395
EFG_IIPF14492408-482
EFG_IVPF03764483-605
EFG_CPF00679607-694
Mtb Structural Proteome models
Model Number1
Model nameRv0684
Template2BM0    APDBCREDO
Template coverage8_688
Template Identity(%)61.0
Model coverage(%)97.9
Normalized DOPE score-0.313

Structure Models from Chopin
Model Number1
Profileb.43.3.1, c.37.1.8, d.14.1.1, d.58.11.1 - 2.40.30.10, 3.30.70.870, 3.40.50.300
Click for model details
zscore102.54
Residue begin10
Residue end701
Model Number2
Profile3.30.70.870
Click for model details
zscore24.1
Residue begin408
Residue end486
Model Number3
Profile3.30.70.240
Click for model details
zscore18.27
Residue begin607
Residue end694
Model Number4
Profiled.14.1.1 - 3.30.230.10
Click for model details
zscore16.31
Residue begin483
Residue end605
Model Number5
Profiled.58.11.1
Click for model details
zscore11.67
Residue begin405
Residue end522
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0684Gene nameConfidence Score
Rv0682rpsL0.998
Rv0683rpsG0.998
Rv0704rplB0.998
Rv0704rplB0.998
Rv0719rplF0.997
Rv0641rplA0.997
Rv0701rplC0.997
Rv0702rplD0.997
Rv0714rplN0.996
Rv0640rplK0.995
Rv0716rplE0.995
Rv0716rplE0.995
Rv3459crpsK0.995
Rv0708rplP0.995
Rv0640rplK0.995
Rv0667rpoB0.994
Rv0667rpoB0.994
Rv0700rpsJ0.994
Rv0667rpoB0.994
Rv0667rpoB0.994
Rv0721rpsE0.994
Rv0721rpsE0.994
Rv0667rpoB0.994
Rv0667rpoB0.994
Rv0718rpsH0.993
Rv2882cfrr0.993
Rv0720rplR0.993
Rv0707rpsC0.993
Rv0707rpsC0.993
Rv0705rpsS0.992
Rv2889ctsf0.992
Rv3458crpsD0.992
Rv2889ctsf0.992
Rv3458crpsD0.992
Rv0703rplW0.992
Rv3457crpoA0.991
Rv3457crpoA0.991
Rv0715rplX0.991
Rv3460crpsM0.991
Rv0723rplO0.991
Rv3457crpoA0.991
Rv3443crplM0.99
Rv0685tuf0.989
Rv0685tuf0.989
Rv3456crplQ0.989
Rv0685tuf0.989
Rv0710rpsQ0.988
Rv0706rplV0.988
Rv0652rplL0.987
Rv0717rpsN10.987
Rv0732secY0.986
Rv0651rplJ0.986
Rv2890crpsB0.984
Rv0668rpoC0.981
Rv0668rpoC0.981
Rv0668rpoC0.981
Rv0668rpoC0.981
Rv0668rpoC0.981
Rv3442crpsI0.98
Rv0056rplI0.979
Rv0056rplI0.979
Rv1643rplT0.977
Rv0733adk0.976
Rv2056crpsN20.973
Rv0639nusG0.973
Rv0639nusG0.973
Rv3462cinfA0.97
Rv1014cpth0.97
Rv1641infC0.969
Rv1641infC0.969
Rv1437pgk0.966
Rv2904crplS0.965
Rv2442crplU0.961
Rv2783cgpsI0.957
Rv2783cgpsI0.957
Rv2783cgpsI0.957
Rv0722rpmD0.957
Rv2783cgpsI0.957
Rv2783cgpsI0.957
Rv0053rpsF0.953
Rv1023eno0.952
Rv1023eno0.952
Rv2785crpsO0.948
Rv0734mapA0.946
Rv2440cobg0.942
Rv2440cobg0.942
Rv2440cobg0.942
Rv2441crpmA0.941
Rv1649pheS0.939
Rv1649pheS0.939
Rv0350dnaK0.939
Rv0041leuS0.938
Rv0041leuS0.938
Rv0041leuS0.938
Rv1007cmetS0.935
Rv1630rpsA0.932
Rv2906ctrmD0.931
Rv0006gyrA0.93
Rv0006gyrA0.93
Rv2909crpsP0.926
Rv1536ileS0.923
Rv1536ileS0.923
Rv1298rpmE0.922
Rv1436gap0.921
Rv0709rpmC0.921
Rv1436gap0.921
Rv2992cgltS0.92
Rv2861cmapB0.917
Rv2150cftsZ0.915
Rv2150cftsZ0.915
Rv2555calaS0.914
Rv2555calaS0.914
Rv2555calaS0.914
Rv2462ctig0.91
Rv2462ctig0.91
Rv2462ctig0.91
Rv1699pyrG0.909
Rv1310atpD0.909
Rv1310atpD0.909
Rv1310atpD0.909
Rv2793ctruB0.909
Rv1699pyrG0.909
Rv2793ctruB0.909
Rv2448cvalS0.907
Rv2448cvalS0.907
Rv2448cvalS0.907
Rv1689tyrS0.905
Rv1689tyrS0.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB02703DrugBankFusidic Acid
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
fusidic acidPubChem0.924516.709
polyphenylalaninePubChem0.766165.189
magnesiumPubChem0.74124.305
Gpp(NH)pPubChem0.721522.196
guanosine diphosphatePubChem0.718443.201
guanosine triphosphatePubChem0.716523.18
guanylyl-(alpha,beta)-methylene-diphosphonatePubChem0.709521.208