SInCRe - Rv1649

Tuberculist information

Gene name	pheS
Protein function	Probable phenylalanyl-tRNA synthetase, alpha chain PheS
Functional category(tuberculist)	information pathways
Gene location(kb)	1858.73
Molecular mass(da)	37371.4
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 341

	  		  	1    MLSPEALTTAVDAAQQAIALADTLDVLARVKTEHLGDRSPLALARQALAVLPKEQRAEAG   60
			  	61   KRVNAARNAAQRSYDERLATLRAERDAAVLVAEGIDVTLPSTRVPAGARHPIIMLAEHVA  120
			  	121  DTFIAMGWELAEGPEVETEQFNFDALNFPADHPARGEQDTFYIAPEDSRQLLRTHTSPVQ  180
			  	181  IRTLLARELPVYIISIGRTFRTDELDATHTPIFHQVEGLAVDRGLSMAHLRGTLDAFARA  240
			  	241  EFGPSARTRIRPHFFPFTEPSAEVDVWFANKIGGAAWVEWGGCGMVHPNVLRATGIDPDL  300
			  	301  YSGFAFGMGLERTLQFRNGIPDMRDMVEGDVRFSLPFGVGA

Known structures in the PDB

No Known structures

Number of amino acids : 341

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Phe_tRNA-synt_N	PF02912	19-90
tRNA-synt_2d	PF01409	94-337

Mtb Structural Proteome models

Model Number	1
Model name	Rv1649
Template	1B7Y APDB CREDO
Template coverage	86_347
Template Identity(%)	45.9
Model coverage(%)	71.3
Normalized DOPE score	-0.233

Structure Models from Chopin

Model Number	1
Profile	3.30.930.10 Click for model details
zscore	11.23
Residue begin	94
Residue end	337

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1649	Gene name	Confidence Score
Rv1650	pheT	0.999
Rv1650	pheT	0.999
Rv1650	pheT	0.999
Rv1650	pheT	0.999
Rv1112	Rv1112	0.987
Rv1112	Rv1112	0.987
Rv2614c	thrS	0.981
Rv2614c	thrS	0.981
Rv2614c	thrS	0.981
Rv1007c	metS	0.976
Rv1643	rplT	0.969
Rv1641	infC	0.965
Rv1641	infC	0.965
Rv3598c	lysS	0.962
Rv3598c	lysS	0.962
Rv2839c	infB	0.961
Rv2839c	infB	0.961
Rv2839c	infB	0.961
Rv2839c	infB	0.961
Rv2580c	hisS	0.956
Rv2580c	hisS	0.956
Rv3336c	trpS	0.953
Rv3459c	rpsK	0.952
Rv1689	tyrS	0.949
Rv1689	tyrS	0.949
Rv2793c	truB	0.941
Rv2793c	truB	0.941
Rv1536	ileS	0.94
Rv1536	ileS	0.94
Rv0684	fusA1	0.939
Rv0684	fusA1	0.939
Rv0684	fusA1	0.939
Rv0684	fusA1	0.939
Rv0684	fusA1	0.939
Rv0006	gyrA	0.938
Rv0006	gyrA	0.938
Rv1292	argS	0.936
Rv1292	argS	0.936
Rv1292	argS	0.936
Rv2448c	valS	0.933
Rv2448c	valS	0.933
Rv0705	rpsS	0.933
Rv2448c	valS	0.933
Rv2555c	alaS	0.932
Rv2555c	alaS	0.932
Rv3457c	rpoA	0.932
Rv3457c	rpoA	0.932
Rv2555c	alaS	0.932
Rv3457c	rpoA	0.932
Rv0041	leuS	0.93
Rv0041	leuS	0.93
Rv0041	leuS	0.93
Rv2904c	rplS	0.927
Rv3674c	nth	0.927
Rv3458c	rpsD	0.927
Rv3674c	nth	0.927
Rv3458c	rpsD	0.927
Rv2845c	proS	0.927
Rv2845c	proS	0.927
Rv2845c	proS	0.927
Rv3674c	nth	0.927
Rv2572c	aspS	0.925
Rv2572c	aspS	0.925
Rv2572c	aspS	0.925
Rv3834c	serS	0.922
Rv3834c	serS	0.922
Rv0070c	glyA2	0.921
Rv3309c	upp	0.92
Rv0704	rplB	0.917
Rv0704	rplB	0.917
Rv2992c	gltS	0.914
Rv1093	glyA1	0.913
Rv2534c	efp	0.911
Rv2534c	efp	0.911
Rv2534c	efp	0.911
Rv0701	rplC	0.911
Rv0005	gyrB	0.909
Rv0005	gyrB	0.909
Rv0005	gyrB	0.909
Rv0005	gyrB	0.909
Rv0707	rpsC	0.908
Rv0707	rpsC	0.908
Rv3721c	dnaZX	0.903
Rv3721c	dnaZX	0.903
Rv0700	rpsJ	0.903
Rv0683	rpsG	0.903
Rv1406	fmt	0.902
Rv1406	fmt	0.902
Rv0640	rplK	0.901
Rv0640	rplK	0.901

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
L-phenylalaninePubChem	0.982	165.189
p-chlorophenylalaninePubChem	0.817	199.634
L-tyrosinePubChem	0.803	181.189
sulfatePubChem	0.787	96.0626
hydron sulfatePubChem	0.787	196.157
magnesiumPubChem	0.755	24.305
MTyPubChem	0.712	181.189
FA5PubChem	0.712	494.395
DB07817PubChem	0.7	444.53
zincPubChem	0.7	65.409