Rv2448c

Tuberculist information
Gene namevalS
Protein functionProbable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ligase) (valine translase)
Functional category(tuberculist)information pathways
Gene location(kb)2747.59
Molecular mass(da)97820.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 876
	  		  	1    MLPKSWDPAAMESAIYQKWLDAGYFTADPTSTKPAYSIVLPPPNVTGSLHMGHALEHTMM   60
			  	61   DALTRRKRMQGYEVLWQPGTDHAGIATQSVVEQQLAVDGKTKEDLGRELFVDKVWDWKRE  120
			  	121  SGGAIGGQMRRLGDGVDWSRDRFTMDEGLSRAVRTIFKRLYDAGLIYRAERLVNWSPVLQ  180
			  	181  TAISDLEVNYRDVEGELVSFRYGSLDDSQPHIVVATTRVETMLGDTAIAVHPDDERYRHL  240
			  	241  VGTSLAHPFVDRELAIVADEHVDPEFGTGAVKVTPAHDPNDFEIGVRHQLPMPSILDTKG  300
			  	301  RIVDTGTRFDGMDRFEARVAVRQALAAQGRVVEEKRPYLHSVGHSERSGEPIEPRLSLQW  360
			  	361  WVRVESLAKAAGDAVRNGDTVIHPASMEPRWFSWVDDMHDWCISRQLWWGHRIPIWYGPD  420
			  	421  GEQVCVGPDETPPQGWEQDPDVLDTWFSSALWPFSTLGWPDKTAELEKFYPTSVLVTGYD  480
			  	481  ILFFWVARMMMFGTFVGDDAAITLDGRRGPQVPFTDVFLHGLIRDESGRKMSKSKGNVID  540
			  	541  PLDWVEMFGADALRFTLARGASPGGDLAVSEDAVRASRNFGTKLFNATRYALLNGAAPAP  600
			  	601  LPSPNELTDADRWILGRLEEVRAEVDSAFDGYEFSRACESLYHFAWDEFCDWYLELAKTQ  660
			  	661  LAQGLTHTTAVLAAGLDTLLRLLHPVIPFLTEALWLALTGRESLVSADWPEPSGISVDLV  720
			  	721  AAQRINDMQKLVTEVRRFRSDQGLADRQKVPARMHGVRDSDLSNQVAAVTSLAWLTEPGP  780
			  	781  DFEPSVSLEVRLGPEMNRTVVVELDTSGTIDVAAERRRLEKELAGAQKELASTAAKLANA  840
			  	841  DFLAKAPDAVIAKIRDRQRVAQQETERITTRLAALQ

Known structures in the PDB
No Known structures
1 88 175 262 349 436 523 610 697 784 871 Range: 14 to 434  |  Coverage: 47% tRNA-synt_1 Range: 430 to 570  |  Coverage: 15% tRNA-synt_1 Range: 611 to 754  |  Coverage: 16% Anticodon_1 Range: 811 to 876  |  Coverage: 7% Val_tRNA-synt_C Range: 2 to 875  |  Coverage: 99% 1 Range: 1 to 421  |  Coverage: 47% 1 Range: 811 to 875  |  Coverage: 7% 2 Range: 130 to 329  |  Coverage: 22% 3 Range: 559 to 758  |  Coverage: 22% 4
Number of amino acids : 876
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
tRNA-synt_1PF0013314-434
tRNA-synt_1PF00133430-570
Anticodon_1PF08264611-754
Val_tRNA-synt_CPF10458811-876
Mtb Structural Proteome models
Model Number1
Model nameRv2448c
Template1GAX    APDBCREDO
Template coverage3_861
Template Identity(%)43.9
Model coverage(%)99.7
Normalized DOPE score-0.444

Structure Models from Chopin
Model Number1
Profilea.2.7.3, a.27.1.1, b.51.1.1 - 1.10.287.380, 1.10.730.10, 3.30.1170.10, 3.40.50.620, 3.90.740.10
Click for model details
zscore61
Residue begin1
Residue end421
Model Number2
Profile1.10.287.380
Click for model details
zscore14.61
Residue begin811
Residue end875
Model Number3
Profileb.51.1.1
Click for model details
zscore12.76
Residue begin130
Residue end329
Model Number4
Profileb.51.1.1
Click for model details
zscore12.76
Residue begin559
Residue end758
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2448cGene nameConfidence Score
Rv2447cfolC0.994
Rv2447cfolC0.994
Rv2210cilvE0.989
Rv2614cthrS0.988
Rv2614cthrS0.988
Rv2614cthrS0.988
Rv2580chisS0.986
Rv2580chisS0.986
Rv3580ccysS10.968
Rv3580ccysS10.968
Rv3834cserS0.968
Rv3834cserS0.968
Rv2462ctig0.966
Rv2462ctig0.966
Rv2462ctig0.966
Rv3356cfolD0.959
Rv3356cfolD0.959
Rv3396cguaA0.959
Rv3396cguaA0.959
Rv3396cguaA0.959
Rv2839cinfB0.955
Rv2839cinfB0.955
Rv2839cinfB0.955
Rv2839cinfB0.955
Rv3598clysS0.953
Rv3598clysS0.953
Rv2445cndkA0.949
Rv0733adk0.949
Rv2555calaS0.948
Rv2555calaS0.948
Rv2555calaS0.948
Rv1699pyrG0.945
Rv1699pyrG0.945
Rv2457cclpX0.944
Rv2457cclpX0.944
Rv2457cclpX0.944
Rv2572caspS0.942
Rv2572caspS0.942
Rv2572caspS0.942
Rv1689tyrS0.939
Rv1689tyrS0.939
Rv3674cnth0.937
Rv3674cnth0.937
Rv3674cnth0.937
Rv3336ctrpS0.935
Rv1649pheS0.933
Rv1649pheS0.933
Rv1112Rv11120.933
Rv1112Rv11120.933
Rv0700rpsJ0.932
Rv1380pyrB0.932
Rv1380pyrB0.932
Rv2992cgltS0.93
Rv3459crpsK0.926
Rv3628ppa0.925
Rv3309cupp0.922
Rv1093glyA10.921
Rv0189cilvD0.921
Rv0070cglyA20.92
Rv2763cdfrA0.918
Rv2404clepA0.918
Rv2404clepA0.918
Rv2404clepA0.918
Rv2404clepA0.918
Rv0716rplE0.917
Rv0716rplE0.917
Rv0640rplK0.917
Rv0640rplK0.917
Rv0685tuf0.916
Rv2441crpmA0.916
Rv0685tuf0.916
Rv0685tuf0.916
Rv2916cffh0.914
Rv2916cffh0.914
Rv2916cffh0.914
Rv0719rplF0.913
Rv1023eno0.909
Rv1023eno0.909
Rv0684fusA10.907
Rv0684fusA10.907
Rv0684fusA10.907
Rv0684fusA10.907
Rv0684fusA10.907
Rv0668rpoC0.905
Rv0668rpoC0.905
Rv0668rpoC0.905
Rv0668rpoC0.905
Rv0668rpoC0.905
Rv0337caspC0.904
Rv2883cpyrH0.902
Rv0053rpsF0.902
Rv2357cglyS0.901
Rv2357cglyS0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
L-valinePubChem0.952117.146
valylPubChem0.795157.253
alpha-ketobutyratePubChem0.71102.089