Rv2614c

Tuberculist information
Gene namethrS
Protein functionProbable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)
Functional category(tuberculist)information pathways
Gene location(kb)2941.19
Molecular mass(da)77121.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 692
	  		  	1    MSAPAQPAPGVDGGDPSQARIRVPAGTTAATAVGEAGLPRRGTPDAIVVVRDADGNLRDL   60
			  	61   SWVPDVDTDITPVAANTDDGRSVIRHSTAHVLAQAVQELFPQAKLGIGPPITDGFYYDFD  120
			  	121  VPEPFTPEDLAALEKRMRQIVKEGQLFDRRVYESTEQARAELANEPYKLELVDDKSGDAE  180
			  	181  IMEVGGDELTAYDNLNPRTRERVWGDLCRGPHIPTTKHIPAFKLTRSSAAYWRGDQKNAS  240
			  	241  LQRIYGTAWESQEALDRHLEFIEEAQRRDHRKLGVELDLFSFPDEIGSGLAVFHPKGGIV  300
			  	301  RRELEDYSRRKHTEAGYQFVNSPHITKAQLFHTSGHLDWYADGMFPPMHIDAEYNADGSL  360
			  	361  RKPGQDYYLKPMNCPMHCLIFRARGRSYRELPLRLFEFGTVYRYEKSGVVHGLTRVRGLT  420
			  	421  MDDAHIFCTRDQMRDELRSLLRFVLDLLADYGLTDFYLELSTKDPEKFVGAEEVWEEATT  480
			  	481  VLAEVGAESGLELVPDPGGAAFYGPKISVQVKDALGRTWQMSTIQLDFNFPERFGLEYTA  540
			  	541  ADGTRHRPVMIHRALFGSIERFFGILTEHYAGAFPAWLAPVQVVGIPVADEHVAYLEEVA  600
			  	601  TQLKSHGVRAEVDASDDRMAKKIVHHTNHKVPFMVLAGDRDVAAGAVSFRFGDRTQINGV  660
			  	661  ARDDAVAAIVAWIADRENAVPTAELVKVAGRE

Known structures in the PDB
No Known structures
1 70 139 208 277 346 415 484 553 622 691 Range: 180 to 245  |  Coverage: 9% tRNA_SAD Range: 300 to 479  |  Coverage: 25% tRNA-synt_2b Range: 582 to 672  |  Coverage: 13% HGTP_anticodon Range: 9 to 685  |  Coverage: 97% 1 Range: 11 to 683  |  Coverage: 97% 1 Range: 10 to 250  |  Coverage: 34% 2 Range: 74 to 268  |  Coverage: 28% 3 Range: 78 to 178  |  Coverage: 14% 4 Range: 567 to 692  |  Coverage: 18% 5 Range: 582 to 672  |  Coverage: 13% 6 Range: 10 to 75  |  Coverage: 9% 7
Number of amino acids : 692
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
tRNA_SADPF07973180-245
tRNA-synt_2bPF00587300-479
HGTP_anticodonPF03129582-672
Mtb Structural Proteome models
Model Number1
Model nameRv2614c
Template1QF6    APDBCREDO
Template coverage2_642
Template Identity(%)38.5
Model coverage(%)97.7
Normalized DOPE score-0.195

Structure Models from Chopin
Model Number1
Profilec.51.1.1, d.104.1.1, d.15.10.1, d.67.1.1 - 3.10.20.30, 3.30.54.20, 3.30.930.10, 3.30.980.10, 3.40.50.800
Click for model details
zscore103.44
Residue begin11
Residue end683
Model Number2
Profiled.15.10.1, d.67.1.1 - 3.10.20.30, 3.30.54.20, 3.30.980.10
Click for model details
zscore45.14
Residue begin10
Residue end250
Model Number3
Profiled.67.1.1
Click for model details
zscore40.04
Residue begin74
Residue end268
Model Number4
Profile3.30.980.10
Click for model details
zscore29.84
Residue begin78
Residue end178
Model Number5
Profilec.51.1.1
Click for model details
zscore16.94
Residue begin567
Residue end692
Model Number6
Profile3.40.50.800
Click for model details
zscore13.98
Residue begin582
Residue end672
Model Number7
Profiled.15.10.1
Click for model details
zscore8.72
Residue begin10
Residue end75
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2614cGene nameConfidence Score
Rv2448cvalS0.988
Rv2448cvalS0.988
Rv2448cvalS0.988
Rv1536ileS0.987
Rv1536ileS0.987
Rv2580chisS0.985
Rv2580chisS0.985
Rv1689tyrS0.981
Rv1649pheS0.981
Rv3336ctrpS0.981
Rv1649pheS0.981
Rv1689tyrS0.981
Rv3834cserS0.979
Rv3834cserS0.979
Rv3598clysS0.976
Rv3598clysS0.976
Rv3580ccysS10.974
Rv3580ccysS10.974
Rv1641infC0.972
Rv1641infC0.972
Rv2555calaS0.966
Rv2572caspS0.966
Rv2572caspS0.966
Rv2572caspS0.966
Rv2555calaS0.966
Rv2555calaS0.966
Rv1643rplT0.962
Rv2916cffh0.956
Rv2916cffh0.956
Rv2916cffh0.956
Rv1112Rv11120.955
Rv1112Rv11120.955
Rv2357cglyS0.952
Rv2357cglyS0.952
Rv1023eno0.947
Rv1023eno0.947
Rv1292argS0.945
Rv1292argS0.945
Rv1292argS0.945
Rv2882cfrr0.941
Rv1606hisI0.938
Rv0440groEL20.936
Rv1295thrC0.934
Rv2992cgltS0.933
Rv2440cobg0.932
Rv2440cobg0.932
Rv2440cobg0.932
Rv2921cftsY0.93
Rv1642rpmI0.93
Rv0189cilvD0.93
Rv2921cftsY0.93
Rv1093glyA10.928
Rv1007cmetS0.927
Rv0070cglyA20.925
Rv2121chisG0.923
Rv2121chisG0.923
Rv0951sucC0.92
Rv0951sucC0.92
Rv3417cgroEL10.919
Rv1299prfA0.918
Rv1299prfA0.918
Rv0683rpsG0.917
Rv2925crnc0.916
Rv2925crnc0.916
Rv0350dnaK0.915
Rv1612trpB0.915
Rv1383carA0.914
Rv1383carA0.914
Rv3609cfolE0.914
Rv0952sucD0.914
Rv0952sucD0.914
Rv2612cpgsA10.911
Rv2404clepA0.906
Rv2404clepA0.906
Rv2404clepA0.906
Rv2404clepA0.906
Rv2613cRv2613c0.904
Rv0041leuS0.903
Rv0041leuS0.903
Rv0041leuS0.903
Rv1699pyrG0.902
Rv1699pyrG0.902
Rv3721cdnaZX0.901
Rv3721cdnaZX0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
L-threoninePubChem0.977119.119
zincPubChem0.8665.409
TSBPubChem0.793447.424
L-serinePubChem0.739105.093
SersaPubChem0.734433.397
A3sPubChem0.734353.334
adenosine triphosphatePubChem0.701507.181