Rv3609c

Tuberculist information
Gene namefolE
Protein functionGTP cyclohydrolase I FolE (GTP-ch-I)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)4049.98
Molecular mass(da)22394.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 202
	  		  	1    MSQLDSRSASARIRVFDQQRAEAAVRELLYAIGEDPDRDGLVATPSRVARSYREMFAGLY   60
			  	61   TDPDSVLNTMFDEDHDELVLVKEIPMYSTCEHHLVAFHGVAHVGYIPGDDGRVTGLSKIA  120
			  	121  RLVDLYAKRPQVQERLTSQIADALMKKLDPRGVIVVIEAEHLCMAMRGVRKPGSVTTTSA  180
			  	181  VRGLFKTNAASRAEALDLILRK

Known structures in the PDB
No Known structures
1 21 41 61 81 101 121 141 161 181 201 Range: 21 to 200  |  Coverage: 88% GTP_cyclohydroI Range: 22 to 200  |  Coverage: 88% 1 Range: 1 to 202  |  Coverage: 99% 1
Number of amino acids : 202
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GTP_cyclohydroIPF0122721-200
Mtb Structural Proteome models
Model Number1
Model nameRv3609c
Template1IS8    APDBCREDO
Template coverage63_240
Template Identity(%)51.7
Model coverage(%)88.1
Normalized DOPE score-0.573

Structure Models from Chopin
Model Number1
Profiled.96.1.1
Click for model details
zscore35.63
Residue begin1
Residue end202
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3609cGene nameConfidence Score
Rv3606cfolK0.998
Rv3608cfolP10.995
Rv3607cfolB0.993
Rv2445cndkA0.978
Rv3356cfolD0.976
Rv3356cfolD0.976
Rv2447cfolC0.96
Rv2447cfolC0.96
Rv1617pykA0.954
Rv1617pykA0.954
Rv3610cftsH0.943
Rv3610cftsH0.943
Rv3610cftsH0.943
Rv3109moaA10.941
Rv3109moaA10.941
Rv3109moaA10.941
Rv0869cmoaA20.937
Rv0869cmoaA20.937
Rv0869cmoaA20.937
Rv1207folP20.921
Rv3111moaC10.918
Rv0864moaC20.916
Rv3324cmoaC30.915
Rv2614cthrS0.914
Rv3624chpt0.914
Rv2614cthrS0.914
Rv2614cthrS0.914
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
guanosine triphosphatePubChem0.988523.18
dihydroneopterin triphosphatePubChem0.972495.17
tetrahydrobiopterinPubChem0.945241.247
pyrophosphatePubChem0.943177.975
formatePubChem0.94245.0174
6R-L-erythro-5,6,7,8-tetrahydrobiopterinPubChem0.939241.247
H(+)PubChem0.9072.01588
deuteriumPubChem0.9062.01588
dihydroneopterin monophosphatePubChem0.9335.211
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
biopterinPubChem0.866237.215
zincPubChem0.8665.409
pteridinePubChem0.848132.123
7,8-dihydrobiopterinPubChem0.845239.231
2,4-diamino-6-hydroxypyrimidinePubChem0.821126.117
dexamethasonePubChem0.798392.461
8-hydroxyguanosine triphosphatePubChem0.779539.18
dihydrobiopterinPubChem0.777239.231
folatePubChem0.772441.397
NAMDAPubChem0.76695.0524
pterinPubChem0.765163.137
L-dopaPubChem0.757197.188
dopaminePubChem0.743153.178
neopterinPubChem0.734253.215
8-oxodeoxyguanosinePubChem0.733523.18
atorvastatinPubChem0.729558.64
5-formyltetrahydrofolatePubChem0.724473.439
dihydrofolatePubChem0.723443.413
serotoninPubChem0.718176.215
sepiapterinPubChem0.717237.215
leucovorinPubChem0.709473.439