Rv3109

Tuberculist information
Gene namemoaA1
Protein functionProbable molybdenum cofactor biosynthesis protein A MoaA1
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3477.65
Molecular mass(da)39959.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 359
	  		  	1    MSTPTLPDMVAPSPRVRVKDRCRRMMGDLRLSVIDQCNLRCRYCMPEEHYTWLPRQDLLS   60
			  	61   VKEISAIVDVFLSVGVSKVRITGGEPLIRPDLPEIVRTLSAKVGEDSGLRDLAITTNGVL  120
			  	121  LADRVDGLKAAGMKRITVSLDTLQPERFKAISQRNSHDKVIAGIKAVAAAGFTDTKIDTT  180
			  	181  VMRGANHDELADLIEFARTVNAEVRFIEYMDVGGATHWAWEKVFTKANMLESLEKRYGRI  240
			  	241  EPLPKHDTAPANRYALPDGTTFGIIASTTEPFCATCDRSRLTADGLWLHCLYAISGINLR  300
			  	301  EPLRAGATHDDLVETVTTGWRRRTDRGAEQRLAQRERGVFLPLSTLKADPHLEMHTRGG

Known structures in the PDB
No Known structures
1 36 71 106 141 176 211 246 281 316 351 Range: 31 to 197  |  Coverage: 46% Radical_SAM Range: 32 to 143  |  Coverage: 30% Fer4_14 Range: 202 to 329  |  Coverage: 35% Mob_synth_C Range: 17 to 334  |  Coverage: 88% 1 Range: 17 to 340  |  Coverage: 89% 1
Number of amino acids : 359
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Radical_SAMPF0405531-197
Fer4_14PF1339432-143
Mob_synth_CPF06463202-329
Mtb Structural Proteome models
Model Number1
Model nameRv3109
Template1TV8    APDBCREDO
Template coverage4_323
Template Identity(%)37.4
Model coverage(%)88.3
Normalized DOPE score-0.648

Structure Models from Chopin
Model Number1
Profilec.1.28.3 - 3.20.20.70
Click for model details
zscore52.89
Residue begin17
Residue end340
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3109Gene nameConfidence Score
Rv3119moaE10.999
Rv3323cmoaX0.998
Rv3111moaC10.998
Rv3323cmoaX0.998
Rv0438cmoeA20.996
Rv0438cmoeA20.996
Rv0438cmoeA20.996
Rv3112moaD10.993
Rv0866moaE20.992
Rv0994moeA10.986
Rv0994moeA10.986
Rv0994moeA10.986
Rv3324cmoaC30.982
Rv0864moaC20.966
Rv3116moeB20.964
Rv3116moeB20.964
Rv3116moeB20.964
Rv3609cfolE0.941
Rv2453cmobA0.931
Rv0865mog0.915
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
molybdenum cofactorPubChem0.89522.283
molybdopterinPubChem0.882397.368
cyclic pyranopterin monophosphatePubChem0.792363.221
molybdenumPubChem0.71195.94