Rv3119

Tuberculist information
Gene namemoaE1
Protein functionProbable molybdenum cofactor biosynthesis protein E MoaE1 (molybdopterin converting factor large subunit) (molybdopterin [MPT] converting factor, subunit 2)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3485.13
Molecular mass(da)15920.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 147
	  		  	1    MANVVAEGAYPYCRLTDQPLSVDEVLAAVSGPEQGGIVIFVGNVRDHNAGHDVTRLFYEA   60
			  	61   YPPMVIRTLMSIIGRCEDKAEGVRVAVAHRTGELQIGDAAVVIGASAPHRAEAFDAARMC  120
			  	121  IELLKQEVPIWKKEFSSTGAEWVGDRP

Known structures in the PDB
PDB ID2WP4
Total residue count294
Number of chains2
MethodX-RAY
Resolution2.49
1 15 29 43 57 71 85 99 113 127 141 Range: 12 to 128  |  Coverage: 78% MoaE Range: 10 to 137  |  Coverage: 86% 1 Range: 9 to 133  |  Coverage: 84% 2 Range: 9 to 147  |  Coverage: 93% 1
Number of amino acids : 147
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MoaEPF0239112-128
Mtb Structural Proteome models
Model Number1
Model nameRv3119_2wp4_A
Template2WP4    APDBCREDO
Template coverage10_137
Template Identity(%)100.0
Model coverage(%)85.8
Normalized DOPE score-1.476

Model Number2
Model nameRv3119
Template1NVJ    BPDBCREDO
Template coverage2_127
Template Identity(%)36.8
Model coverage(%)83.8
Normalized DOPE score-0.706

Structure Models from Chopin
Model Number1
Profiled.41.5.1 - 3.90.1170.40
Click for model details
zscore29.25
Residue begin9
Residue end147
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3119Gene nameConfidence Score
Rv3109moaA10.999
Rv3109moaA10.999
Rv3109moaA10.999
Rv0869cmoaA20.993
Rv0869cmoaA20.993
Rv0869cmoaA20.993
Rv3111moaC10.993
Rv3112moaD10.991
Rv3116moeB20.987
Rv3116moeB20.987
Rv3116moeB20.987
Rv0864moaC20.984
Rv3324cmoaC30.98
Rv3120Rv31200.975
Rv3118sseC10.96
Rv3206cmoeB10.947
Rv3206cmoeB10.947
Rv0438cmoeA20.947
Rv3206cmoeB10.947
Rv0438cmoeA20.947
Rv0438cmoeA20.947
Rv0866moaE20.911
Rv3323cmoaX0.91
Rv3323cmoaX0.91
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glycerolPubChem0.96692.0938
calciumPubChem0.940.078
molybdopterinPubChem0.889397.368
molybdenum cofactorPubChem0.869522.283
1,4-dimethyl-1,4-diphenyl-2-tetrazenePubChem0.831240.304
cyclic pyranopterin monophosphatePubChem0.716363.221