Rv0866

Tuberculist information
Gene namemoaE2
Protein functionProbable molybdenum cofactor biosynthesis protein E2 MoaE2 (molybdopterin converting factor large subunit) (molybdopterin [MPT] converting factor, subunit 2)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)963.869
Molecular mass(da)15048.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 141
	  		  	1    MTQVLRAALTDQPIFLAEHEELVSHRSAGAIVGFVGMIRDRDGGRGVLRLEYSAHPSAAQ   60
			  	61   VLADLVAEVAEESSGVRAVAASHRIGVLQVGEAALVAAVAADHRRAAFGTCAHLVETIKA  120
			  	121  RLPVWKHQFFEDGTDEWVGSV

Known structures in the PDB
No Known structures
1 15 29 43 57 71 85 99 113 127 141 Range: 6 to 122  |  Coverage: 82% MoaE Range: 12 to 138  |  Coverage: 89% 1 Range: 3 to 141  |  Coverage: 97% 1
Number of amino acids : 141
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MoaEPF023916-122
Mtb Structural Proteome models
Model Number1
Model nameRv0866
Template1FM0    EPDBCREDO
Template coverage11_137
Template Identity(%)33.3
Model coverage(%)89.4
Normalized DOPE score0.627

Structure Models from Chopin
Model Number1
Profiled.41.5.1 - 3.90.1170.40
Click for model details
zscore25.89
Residue begin3
Residue end141
Binding pockets
STRING
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Protein interacting with Rv0866Gene nameConfidence Score
Rv0864moaC20.997
Rv0869cmoaA20.992
Rv0869cmoaA20.992
Rv0869cmoaA20.992
Rv3109moaA10.992
Rv3109moaA10.992
Rv3109moaA10.992
Rv3111moaC10.978
Rv3324cmoaC30.977
Rv0865mog0.966
Rv3116moeB20.954
Rv3116moeB20.954
Rv3116moeB20.954
Rv3206cmoeB10.937
Rv3206cmoeB10.937
Rv3206cmoeB10.937
Rv3112moaD10.921
Rv3323cmoaX0.911
Rv3323cmoaX0.911
Rv3119moaE10.911
Rv0438cmoeA20.908
Rv0438cmoeA20.908
Rv0438cmoeA20.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions