Rv0869c

Tuberculist information
Gene namemoaA2
Protein functionProbable molybdenum cofactor biosynthesis protein A2 MoaA2
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)966.265
Molecular mass(da)38985.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 360
	  		  	1    MTLTALGMPALRSRTNGIADPRVVPTTGPLVDTFGRVANDLRVSLTDRCNLRCSYCMPER   60
			  	61   GLRWLPGEQLLRPDELARLIHIAVTRLGVTSVRFTGGEPLLAHHLDEVVAATARLRPRPE  120
			  	121  ISLTTNGVGLARRAGALAEAGLDRVNVSLDSIDRAHFAAITRRDRLAHVLAGLAAAKAAG  180
			  	181  LTPVKVNAVLDPTTGREDVVDLLRFCLERGYQLRVIEQMPLDAGHSWRRNIALSADDVLA  240
			  	241  ALRPHFRLRPDPAPRGSAPAELWLVDAGPNTPRGRFGVIASVSHAFCSTCDRTRLTADGQ  300
			  	301  IRSCLFSTEETDLRRLLRGGADDDAIEAAWRAAMWSKPAGHGINAPDFIQPDRPMSAIGG  360

Known structures in the PDB
No Known structures
1 37 73 109 145 181 217 253 289 325 361 Range: 43 to 206  |  Coverage: 45% Radical_SAM Range: 44 to 140  |  Coverage: 26% Fer4_14 Range: 211 to 343  |  Coverage: 36% Mob_synth_C Range: 29 to 353  |  Coverage: 90% 1 Range: 29 to 354  |  Coverage: 90% 1
Number of amino acids : 360
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Radical_SAMPF0405543-206
Fer4_14PF1339444-140
Mob_synth_CPF06463211-343
Mtb Structural Proteome models
Model Number1
Model nameRv0869c
Template1TV8    APDBCREDO
Template coverage4_328
Template Identity(%)32.9
Model coverage(%)90.0
Normalized DOPE score-0.223

Structure Models from Chopin
Model Number1
Profilec.1.28.3 - 3.20.20.70
Click for model details
zscore57.02
Residue begin29
Residue end354
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0869cGene nameConfidence Score
Rv0438cmoeA20.994
Rv0438cmoeA20.994
Rv0438cmoeA20.994
Rv0864moaC20.994
Rv3324cmoaC30.993
Rv3111moaC10.993
Rv3119moaE10.993
Rv0866moaE20.992
Rv0994moeA10.986
Rv0994moeA10.986
Rv0994moeA10.986
Rv3323cmoaX0.984
Rv3323cmoaX0.984
Rv3112moaD10.981
Rv0865mog0.963
Rv0868cmoaD20.948
Rv3609cfolE0.937
Rv2453cmobA0.932
Rv1589bioB0.919
Rv1589bioB0.919
Rv0984moaB20.912
Rv1857modA0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
molybdenum cofactorPubChem0.755522.283
molybdopterinPubChem0.744397.368
cyclic pyranopterin monophosphatePubChem0.701363.221