Rv0984

Tuberculist information
Gene namemoaB2
Protein functionPossible pterin-4-alpha-carbinolamine dehydratase MoaB2 (PHS) (4-alpha- hydroxy-tetrahydropterin dehydratase) (pterin-4-a-carbinolamine dehydratase) (phenylalanine hydroxylase-stimulating protein) (PHS) (pterin carbinolamine dehydratase) (PCD)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1100.46
Molecular mass(da)18441
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 181
	  		  	1    MKVAAQCSKLGYTVAPMEQRAELVVGRALVVVVDDRTAHGDEDHSGPLVTELLTEAGFVV   60
			  	61   DGVVAVSADEVEIRNALNTAVIGGVDLVVSVGGTGVTPRDVTPEATRDILDREILGIAEA  120
			  	121  IRASGLSAGIVDAGLSRGLAGVSGSTLVVNLAGSRYAVRDGMATLNPLAAQIIGQLSSLE  180
			  	181  I

Known structures in the PDB
No Known structures
1 19 37 55 73 91 109 127 145 163 181 Range: 24 to 171  |  Coverage: 81% MoCF_biosynth Range: 25 to 176  |  Coverage: 83% 1 Range: 17 to 181  |  Coverage: 90% 1
Number of amino acids : 181
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MoCF_biosynthPF0099424-171
Mtb Structural Proteome models
Model Number1
Model nameRv0984
Template1Y5E    APDBCREDO
Template coverage14_166
Template Identity(%)37.5
Model coverage(%)83.4
Normalized DOPE score-1.21

Structure Models from Chopin
Model Number1
Profilec.57.1.1 - 3.40.980.10
Click for model details
zscore26.56
Residue begin17
Residue end181
Binding pockets
STRING
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Protein interacting with Rv0984Gene nameConfidence Score
Rv0438cmoeA20.97
Rv0438cmoeA20.97
Rv0438cmoeA20.97
Rv3111moaC10.966
Rv0864moaC20.95
Rv3324cmoaC30.941
Rv0983pepD0.933
Rv0983pepD0.933
Rv0994moeA10.919
Rv0994moeA10.919
Rv0994moeA10.919
Rv0869cmoaA20.912
Rv0869cmoaA20.912
Rv0869cmoaA20.912
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions