Rv0983

Tuberculist information
Gene namepepD
Protein functionProbable serine protease PepD (serine proteinase) (MTB32B)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1099.07
Molecular mass(da)46452.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 464
	  		  	1    MAKLARVVGLVQEEQPSDMTNHPRYSPPPQQPGTPGYAQGQQQTYSQQFDWRYPPSPPPQ   60
			  	61   PTQYRQPYEALGGTRPGLIPGVIPTMTPPPGMVRQRPRAGMLAIGAVTIAVVSAGIGGAA  120
			  	121  ASLVGFNRAPAGPSGGPVAASAAPSIPAANMPPGSVEQVAAKVVPSVVMLETDLGRQSEE  180
			  	181  GSGIILSAEGLILTNNHVIAAAAKPPLGSPPPKTTVTFSDGRTAPFTVVGADPTSDIAVV  240
			  	241  RVQGVSGLTPISLGSSSDLRVGQPVLAIGSPLGLEGTVTTGIVSALNRPVSTTGEAGNQN  300
			  	301  TVLDAIQTDAAINPGNSGGALVNMNAQLVGVNSAIATLGADSADAQSGSIGLGFAIPVDQ  360
			  	361  AKRIADELISTGKASHASLGVQVTNDKDTLGAKIVEVVAGGAAANAGVPKGVVVTKVDDR  420
			  	421  PINSADALVAAVRSKAPGATVALTFQDPSGGSRTVQVTLGKAEQ

Known structures in the PDB
PDB ID1Y8T
Total residue count972
Number of chains3
MethodX-RAY
Resolution2
PDB ID2Z9I
Total residue count999
Number of chains9
MethodX-RAY
Resolution2
1 47 93 139 185 231 277 323 369 415 461 Range: 181 to 331  |  Coverage: 32% Trypsin_2 Range: 377 to 459  |  Coverage: 17% PDZ_2 Range: 6 to 314  |  Coverage: 66% 1 Range: 154 to 462  |  Coverage: 66% 2 Range: 146 to 464  |  Coverage: 68% 1 Range: 156 to 364  |  Coverage: 44% 2 Range: 377 to 459  |  Coverage: 17% 3 Range: 12 to 445  |  Coverage: 93% 4
Number of amino acids : 464
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Trypsin_2PF13365181-331
PDZ_2PF13180377-459
Mtb Structural Proteome models
Model Number1
Model nameRv0983_2z9i_A
Template2Z9I    APDBCREDO
Template coverage6_314
Template Identity(%)100.0
Model coverage(%)66.4
Normalized DOPE score-1.35

Model Number2
Model nameRv0983
Template1Y8T    APDBCREDO
Template coverage6_314
Template Identity(%)96.5
Model coverage(%)66.4
Normalized DOPE score-0.669

Structure Models from Chopin
Model Number1
Profileb.36.1.4, b.47.1.1 - 2.40.10.10
Click for model details
zscore45.21
Residue begin146
Residue end464
Model Number2
Profileb.47.1.1
Click for model details
zscore17.24
Residue begin156
Residue end364
Model Number3
Profileb.36.1.4
Click for model details
zscore16.56
Residue begin377
Residue end459
Model Number4
Profileb.47.1.1
Click for model details
zscore12.04
Residue begin12
Residue end445
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0983Gene nameConfidence Score
Rv0984moaB20.933
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
selenomethioninePubChem0.925196.106
SeMetPubChem0.925196.106