Rv0994

Tuberculist information
Gene namemoeA1
Protein functionProbable molybdopterin biosynthesis protein MoeA1
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1110.27
Molecular mass(da)44304.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 426
	  		  	1    VRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVD   60
			  	61   VAGVGDTGGVQVFADHGDLDGRDVLTLPVMGTIEAGARTLSRLQPRQAVRVQTGAPLPTL  120
			  	121  ADAVLPLRWTDGGMSRVRVLRGAPSGAYVRRAGDDVQPGDVAVRAGTIIGAAQVGLLAAV  180
			  	181  GRERVLVHPRPRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDACAEVNRVGIVS  240
			  	241  NDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSELGEMEVVRVAMHPGSVQGFG  300
			  	301  QLGRDGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRHPMRRIVSARTLSPITSVAGRK  360
			  	361  GYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANCLVVVPTGAEQIRTGEIVDVA  420
			  	421  FLAQHG

Known structures in the PDB
No Known structures
1 43 85 127 169 211 253 295 337 379 421 Range: 1 to 181  |  Coverage: 42% MoeA_N Range: 194 to 333  |  Coverage: 32% MoCF_biosynth Range: 346 to 422  |  Coverage: 17% MoeA_C Range: 4 to 422  |  Coverage: 98% 1 Range: 1 to 426  |  Coverage: 99% 1 Range: 1 to 181  |  Coverage: 42% 2 Range: 189 to 344  |  Coverage: 36% 3 Range: 41 to 155  |  Coverage: 26% 4 Range: 346 to 422  |  Coverage: 17% 5 Range: 123 to 181  |  Coverage: 13% 6
Number of amino acids : 426
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MoeA_NPF034531-181
MoCF_biosynthPF00994194-333
MoeA_CPF03454346-422
Mtb Structural Proteome models
Model Number1
Model nameRv0994
Template1UZ5    APDBCREDO
Template coverage9_399
Template Identity(%)32.0
Model coverage(%)98.1
Normalized DOPE score0.202

Structure Models from Chopin
Model Number1
Profileb.103.1.1, b.85.6.1, c.57.1.2 - 2.170.190.11, 2.40.340.10, 3.40.980.10, 3.90.105.10
Click for model details
zscore61.7
Residue begin1
Residue end426
Model Number2
Profileb.103.1.1
Click for model details
zscore33.94
Residue begin1
Residue end181
Model Number3
Profilec.57.1.2
Click for model details
zscore32.97
Residue begin189
Residue end344
Model Number4
Profile2.170.190.11
Click for model details
zscore22.55
Residue begin41
Residue end155
Model Number5
Profileb.85.6.1
Click for model details
zscore14.72
Residue begin346
Residue end422
Model Number6
Profile3.90.105.10
Click for model details
zscore11.1
Residue begin123
Residue end181
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0994Gene nameConfidence Score
Rv3109moaA10.986
Rv3109moaA10.986
Rv3109moaA10.986
Rv0869cmoaA20.986
Rv0869cmoaA20.986
Rv0869cmoaA20.986
Rv0865mog0.925
Rv0864moaC20.92
Rv0984moaB20.919
Rv3111moaC10.917
Rv3324cmoaC30.915
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions