Rv0438c

Tuberculist information
Gene namemoeA2
Protein functionProbable molybdopterin biosynthesis protein MoeA2
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)526.143
Molecular mass(da)41989
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 405
	  		  	1    VRSVQEHQRVVAEMMRACRPITVPLTQAQGLVLGGDVVAPLSLPVFDNSAMDGYAVRAED   60
			  	61   TSGATPQNPVMLPVAEDIPAGRADMLTLQPVTAHRIMTGAPVPTGATAIVPVEATDGGVD  120
			  	121  SVAIRQQATPGKHIRRSGEDVAAGTTVLHNGQIVTPAVLGLAAALGLAELPVLPRQRVLV  180
			  	181  ISTGSELASPGTPLQPGQIYESNSIMLAAAVRDAGAAVVATATAGDDVAQFGAILDRYAV  240
			  	241  DADLIITSGGVSAGAYEVVKDAFGSADYRGGDHGVEFVKVAMQPGMPQGVGRVAGTPIVT  300
			  	301  LPGNPVSALVSFEVFIRPPLRMAMGLPDPYRPHRSAVLTASLTSPRGKRQFRRAILDHQA  360
			  	361  GTVISYGPPASHHLRWLASANGLLDIPEDVVEVAAGTQLQVWDLT

Known structures in the PDB
No Known structures
1 41 81 121 161 201 241 281 321 361 401 Range: 1 to 166  |  Coverage: 40% MoeA_N Range: 179 to 322  |  Coverage: 35% MoCF_biosynth Range: 335 to 404  |  Coverage: 17% MoeA_C Range: 1 to 404  |  Coverage: 99% 1 Range: 1 to 405  |  Coverage: 99% 1 Range: 1 to 177  |  Coverage: 43% 2 Range: 174 to 333  |  Coverage: 39% 3 Range: 41 to 140  |  Coverage: 24% 4 Range: 335 to 404  |  Coverage: 17% 5 Range: 109 to 175  |  Coverage: 16% 6
Number of amino acids : 405
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MoeA_NPF034531-166
MoCF_biosynthPF00994179-322
MoeA_CPF03454335-404
Mtb Structural Proteome models
Model Number1
Model nameRv0438c
Template1G8L    APDBCREDO
Template coverage7_404
Template Identity(%)35.4
Model coverage(%)99.5
Normalized DOPE score0.091

Structure Models from Chopin
Model Number1
Profileb.103.1.1, b.85.6.1, c.57.1.2
Click for model details
zscore64.72
Residue begin1
Residue end405
Model Number2
Profileb.103.1.1
Click for model details
zscore34.35
Residue begin1
Residue end177
Model Number3
Profilec.57.1.2
Click for model details
zscore30.85
Residue begin174
Residue end333
Model Number4
Profile2.170.190.11
Click for model details
zscore26.7
Residue begin41
Residue end140
Model Number5
Profileb.85.6.1
Click for model details
zscore15.57
Residue begin335
Residue end404
Model Number6
Profile3.90.105.10
Click for model details
zscore11.75
Residue begin109
Residue end175
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0438cGene nameConfidence Score
Rv3109moaA10.996
Rv3109moaA10.996
Rv3109moaA10.996
Rv0869cmoaA20.994
Rv0869cmoaA20.994
Rv0869cmoaA20.994
Rv0865mog0.983
Rv2453cmobA0.976
Rv0984moaB20.97
Rv3119moaE10.947
Rv0864moaC20.93
Rv1857modA0.919
Rv3111moaC10.917
Rv3324cmoaC30.917
Rv0866moaE20.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
molybdenum cofactorPubChem0.76522.283
molybdopterinPubChem0.735397.368